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Hepatocellular Carcinoma in Non-cirrhotic Liver Arises with a More Advanced Tumoral Appearance: A Single-Center Cohort Study

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dc.contributor.authorKEKLİKKIRAN, ÇAĞLAYAN
dc.contributor.authorsDemirtas, Coskun Ozer; Tolu, Tugba; Keklikkiran, Caglayan; Ozdogan, Osman Cavit; Gunduz, Feyza
dc.date.accessioned2022-03-12T22:55:09Z
dc.date.available2022-03-12T22:55:09Z
dc.date.issued2021
dc.description.abstractBackground: A small proportion of all hepatocellular carcinomas (HCCs) arise in a non-cirrhotic liver (NCL). However, our knowledge about the HCCs developing in a NCL is scarce. This study was undertaken to investigate the characteristics and survival course of this patient group. Methods: We retrospectively analyzed the database of patients with HCC at a tertiary center during a 10-year period (2009-2019). All demographic, clinical, laboratory, and tumoral features with survival outcomes were compared between the HCC-CL and HCC-NCL groups. Results: Out of 384 HCC cases, 112% (n = 43) had no cirrhosis. The dominant etiology in the HCC-NCL group was hepatitis B virus (n = 26, 60.5%), followed by non-alcoholic fatty liver disease (n = 10, 23.2%), and hepatitis C virus (n = 7, 16.3%). The maximum tumor diameter was approximately 2 times larger in the HCC-NCL group (HCC-NCL: 90 mm vs. HCC-CL: 46.5 mm, P < .001) The proportion of patients with vascular (HCC-NCL 27.9% vs. HCC-CL: 8.6%, P <.001) and extrahepatic invasion (HCC-NCL: 14% vs. HCC-CL: 3%, P = .001) were prominently higher in the HCC-NCL group. Patients with HCC-NCL were less often detected in early-curable stages (BCLC 0-A) than those in the HCC-CL group (HCC-NCL: 16.3% vs. HCC-CL 34.9%, P = .004). The overall survival was not different between the 2 groups (HCC-NCL: 19.4 +/- 9.8 months vs. HCC-CL: 17.5 +/- 2.3 months, P = .581). Conclusion: HCC in NCL is diagnosed at more advanced tumoral stages with larger tumor size and more often with vascular and extrahepatic spread. Despite the preserved liver functions, the overall survival is not prolonged in HCCs without cirrhosis, due to the late recognition.
dc.identifier.doi10.5152/tjg.2021.20677
dc.identifier.eissn2148-5607
dc.identifier.pubmed34528882
dc.identifier.urihttps://hdl.handle.net/11424/236663
dc.identifier.wosWOS:000697285200010
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofTURKISH JOURNAL OF GASTROENTEROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNon-cirrhotic
dc.subjecthepatocellular carcinoma
dc.subjectliver
dc.subjectcirrhosis
dc.subjectUNITED-STATES
dc.subjectCIRRHOSIS
dc.subjectHCC
dc.subjectEPIDEMIOLOGY
dc.subjectSURVIVAL
dc.subjectOUTCOMES
dc.subjectDISEASE
dc.titleHepatocellular Carcinoma in Non-cirrhotic Liver Arises with a More Advanced Tumoral Appearance: A Single-Center Cohort Study
dc.typearticle
dspace.entity.typePublication
local.avesis.idc050cea7-da79-4c0c-adad-14a8f23755f2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage693
oaire.citation.issue8
oaire.citation.startPage685
oaire.citation.titleTURKISH JOURNAL OF GASTROENTEROLOGY
oaire.citation.volume32
relation.isAuthorOfPublication2e2ea3a8-5476-4a01-9ae7-c31152fdf024
relation.isAuthorOfPublication.latestForDiscovery2e2ea3a8-5476-4a01-9ae7-c31152fdf024

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