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Glutamate and GABA immunocytochemical electron microscopy in the hippocampal dentate gyrus of normal and genetic absence epilepsy rats

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsSirvanci, S; Meshul, CK; Onat, F; San, T
dc.date.accessioned2022-03-12T17:20:57Z
dc.date.available2022-03-12T17:20:57Z
dc.date.issued2005
dc.description.abstractIt is generally accepted that absence epilepsy results from the impairment of GABAergic and glutamatergic neurotransmission. In particular, besides excessive GABA mediation within the thalamo-cortico-thalamic circuit in absence epilepsy, neuronal networks of the hippocampus have recently received attention. In the present study, we examined the density of glutamate and GABA neurotransmitter immunolabeling in the dentate gyrus of the hippocampus of genetic absence epilepsy rats from Strasbourg (GAERS) compared to the control group. GABA and glutamate were found to exist in synaptic vesicles of the mossy fiber terminals of the control and GAERS groups. The density of glutamate immunolabeling within the mossy fiber terminals in the hilar region of GAERS hippocampus was found to be significantly decreased compared to the control group. There was no difference in the density of immunolabeling within GABA nerve terminals between GAERS and control group. The findings of this study suggest that mechanisms underlying absence seizures in GAERS may also manifest themselves in other brain regions such as the hippocampus. The presence of GABA within synaptic vesicles of mossy fiber terminals, as revealed by high resolution ultrastructural immunocytochemistry, has provided additional evidence to the possible modulatory role of GABA on synaptic transmission between the mossy fiber and the target cell. Published by Elsevier B.V.
dc.identifier.doi10.1016/j.brainres.2005.06.024
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.pubmed16038886
dc.identifier.urihttps://hdl.handle.net/11424/228296
dc.identifier.wosWOS:000231555500013
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofBRAIN RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGAERS
dc.subjecthippocampus
dc.subjectultrastructure
dc.subjectglutamate
dc.subjectGABA
dc.subjectEXCITATORY GRANULE CELLS
dc.subjectMOLECULAR LAYER
dc.subjectFASCIA-DENTATA
dc.subjectMOSSY FIBERS
dc.subjectAMINO-ACIDS
dc.subjectIMMUNOREACTIVITY
dc.subjectEXPRESSION
dc.subjectLOCALIZATION
dc.subjectTRANSPORTERS
dc.subjectRECEPTORS
dc.titleGlutamate and GABA immunocytochemical electron microscopy in the hippocampal dentate gyrus of normal and genetic absence epilepsy rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id7d1c2fda-d40d-4a9b-9f27-91280d07de85
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage115
oaire.citation.issue1-2
oaire.citation.startPage108
oaire.citation.titleBRAIN RESEARCH
oaire.citation.volume1053
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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