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Reference intervals for growth arrest-specific 6 protein in adults

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dc.contributor.authorAY, NADİYE PINAR
dc.contributor.authorsCagman, Zeynep; Ozakpinar, Ozlem Bingol; Cirakli, Zeynep; Gedikbasi, Asuman; Ay, Pinar; Colantonio, David; Uras, Ahmet Riza; Adeli, Khosrow; Uras, Fikriye
dc.date.accessioned2022-03-12T22:24:06Z
dc.date.available2022-03-12T22:24:06Z
dc.date.issued2017
dc.description.abstractThe objective of this study was to establish reference intervals for growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, in human adult plasma according to the Guideline of Clinical and Laboratory Standards Institute (CLSI) C28-A3. Blood samples were collected from 308 healthy volunteers aged 18-72 (157 female, 151 male). A non-parametric approach was used to calculate the reference interval. The plasma GAS6 reference interval was determined, with 90% confidence interval: the lower limit (2.5 percentile) was 2.5 (1.9-3.1) g/L and the upper limit (97.5 percentile)=18.8 (18.0-22.3) g/L. Harris-Boyd's test did not suggest partitioning by age or gender: medians for males [7.8 (5.8-10.7) g/L] and females [9.9 (7.1-13.5) g/L]. Three age-subgroups were tested: 18-29 years (n=168); 30-44 years (n=73); 45-72 years (n=67). The intra- and inter-assay variations were 12.6% (mean, 5.2 +/- 0.7g/L) and 14.0% (mean, 9.2 +/- 1.3g/L), respectively. The mean recovery was 104%. This study reports plasma GAS6 reference intervals established first according to the guideline of CLSI C28-A3.
dc.identifier.doi10.1080/00365513.2016.1275768
dc.identifier.eissn1502-7686
dc.identifier.issn0036-5513
dc.identifier.pubmed28150505
dc.identifier.urihttps://hdl.handle.net/11424/234673
dc.identifier.wosWOS:000395146100006
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemical marker
dc.subjectclinical and laboratory standards nstitute
dc.subjectenzyme-linked mmunosorbent assay
dc.subjectGAS6
dc.subjectinternational federation of clinical chemistry
dc.subjectreference ranges
dc.subjectVitamin K
dc.subjectRECEPTOR TYROSINE KINASE
dc.subjectLABORATORY REFERENCE INTERVALS
dc.subjectVASCULAR SMOOTH-MUSCLE
dc.subjectK-DEPENDENT PROTEINS
dc.subjectPLASMA-CONCENTRATIONS
dc.subjectGAS6 CONCENTRATIONS
dc.subjectAXL
dc.subjectCELLS
dc.subjectEXPRESSION
dc.subjectLIGAND
dc.titleReference intervals for growth arrest-specific 6 protein in adults
dc.typearticle
dspace.entity.typePublication
local.avesis.id45320326-be6c-4354-890a-a4fe94f21a7d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ4
oaire.citation.endPage114
oaire.citation.issue2
oaire.citation.startPage109
oaire.citation.titleSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
oaire.citation.volume77
relation.isAuthorOfPublication899e1c77-c1b2-46d6-a3b8-a71385a78ec0
relation.isAuthorOfPublication.latestForDiscovery899e1c77-c1b2-46d6-a3b8-a71385a78ec0

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