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Variables Affecting Mortality Among COVID-19 Patients With Lung Involvement Admitted to the Emergency Department

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dc.contributor.authorDENİZBAŞI ALTINOK, ARZU
dc.contributor.authorsSacak, Melis Efeoglu; Karacabey, Sinan; Sanri, Erkman; Omercikoglu, Serhad; Unal, Emir; Onur, Ozge Ecmel; Akoglu, Haldun; Denizbasi, Arzu
dc.date.accessioned2022-03-14T09:52:31Z
dc.date.available2022-03-14T09:52:31Z
dc.date.issued2021-01-07
dc.description.abstractIntroduction: A cluster of atypical pneumonia cases in Wuhan, China, turned out to be a highly contagious disease, swept across most of the countries, and soon after was announced as a pandemic. Therefore we aimed to investigate the demographics and factors associated with the disease outcome. Methods: In this retrospective chart review, we screened patients admitted to the emergency department with severe acute respiratory infection due to coronavirus disease 2019 (COVID-19) between March 15, 2020 and April 30, 2020. Age, gender, symptoms, laboratory data, and radiology data were obtained, as well as outcomes and length of stay. Results: We identified 177 patients (54.8% male). Seventy-eight percent of the cases were admitted into wards whereas 22% of the cases were admitted into the intensive care unit (ICU). Twenty-five percent of the cases needed invasive mechanical ventilation during their hospital stay and median length of hospital slay until death or discharge was eight days (interquartile range (IQR) 5.0 - 16.0). Among 177 patients, overall inhospital mortality rate was 19.8% (n=35; male:female=18:17; p=0.6553). In-hospital mortality rates were statistically significantly higher in patients with higher age (64 vs. 74; p=0.0091), respiratory rate (RR) (28 vs. 36; p=0.0002), C-reactive protein (CRP) (54.7 vs. 104.0; p<0.0001), d-dimer (1.2 vs. 3.2; p<0.0001), ferritin (170 vs. 450.4; p<0.0001), fibrinogen (512 vs. 598; p=0.0349), international normalized ratio (INR) (1.1 vs. 1.3; p=0.0001), prothrombin time (PT) (14.8 vs. 17.4; p=0.0001), procalcitonin (0.1 vs. 0.3; p<0.0001), creatinine (0.9 vs. 1.1; p<0.0084), longer length of stay (LOS) (8.0 vs. 13.0; pl.0251) with lower oxygen saturation (sO(2)) (93.0% vs 87.5%; p<0.0001), diastolic blood pressure (DBP) (78 vs. 70; p=0.0039), lymphocyte (1.2 vs. 0.8; p=0.0136), and with positive polymerase chain reaction (PCR) results (28.6% vs. 12.8%; p=0.0118). Conclusion: Patients with older age, higher RR, lower sO(2) and DBP, higher creatinine, d-dimer, INR, CRP, procalcitonin, ferritin, and fibrinogen on initial admission were found to be less likely to survive COVID-19.
dc.identifier.doi10.7759/cureus.12559
dc.identifier.eissn2168-8184
dc.identifier.pubmed33564550
dc.identifier.urihttps://hdl.handle.net/11424/243475
dc.identifier.wosWOS:000606245900018
dc.language.isoeng
dc.publisherCUREUS INC
dc.relation.ispartofCUREUS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcovid-19
dc.subjectoutcomes
dc.subjectmortality
dc.titleVariables Affecting Mortality Among COVID-19 Patients With Lung Involvement Admitted to the Emergency Department
dc.typearticle
dspace.entity.typePublication
local.avesis.idd24f9bac-5905-4b2a-ab42-fd444ae5891a
local.import.packageSS16
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.articlenumbere12559
local.journal.numberofpages8
oaire.citation.issue1
oaire.citation.titleCUREUS
oaire.citation.volume13
relation.isAuthorOfPublication85d7879a-b827-49ad-8b5f-77e6661077c7
relation.isAuthorOfPublication.latestForDiscovery85d7879a-b827-49ad-8b5f-77e6661077c7

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