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A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsAykac A., Terali K., ÖZBEYLİ D., Ede S., Albayrak O., Baser K. H. C., Sener G.
dc.date.accessioned2023-03-27T09:56:45Z
dc.date.available2023-03-27T09:56:45Z
dc.date.issued2022-04-01
dc.description.abstractAlzheimer\"s disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions (dementia) and represents a growing public health concern since the population in the age groups at risk is increasing. The latter raises an urgent need to translate research findings in the basic brain and behavioral sciences into anti-AD drugs and disease-modifying therapies. Origanum onites (L.), also called Turkish oregano, is a perennial and herbaceous plant species grown for centuries for medicinal, cosmetic and culinary purposes. This is the first study to investigate the putative neuroprotective and pro-cognitive activities of O. onites essential oil (OOEO) against scopolamine-induced amnesia of AD-type in Wistar albino rats. The results of behavioral tests revealed that OOEO administration was able to significantly alleviate learning and memory impairments induced by scopolamine in vivo. The observed effects could be attributed to inhibition of acetylcholinesterase activity, attenuation of oxidative stress and prevention of neuronal apoptosis in the hippocampus and frontal cortex of AD rats. Modulation of pro-inflammatory enzymes, including cyclooxygenase-2, inducible nitric oxide synthase and myeloperoxidase, might further contribute to the neuroprotective properties of OEOO, as predicted by our in silico models. These findings offer novel insights into the therapeutic potential of OEOO in patients with AD.
dc.identifier.citationAykac A., Terali K., ÖZBEYLİ D., Ede S., Albayrak O., Baser K. H. C., Sener G., "A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats", METABOLIC BRAIN DISEASE, cilt.37, sa.4, ss.1041-1055, 2022
dc.identifier.doi10.1007/s11011-022-00933-6
dc.identifier.endpage1055
dc.identifier.issn0885-7490
dc.identifier.issue4
dc.identifier.startpage1041
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35201555/
dc.identifier.urihttps://hdl.handle.net/11424/287855
dc.identifier.volume37
dc.language.isoeng
dc.relation.ispartofMETABOLIC BRAIN DISEASE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSİNİR BİLİMİ
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectNEUROSCIENCES
dc.subjectNEUROSCIENCE & BEHAVIOR
dc.subjectLife Sciences (LIFE)
dc.subjectEndocrinology
dc.subjectDevelopmental Neuroscience
dc.subjectEndocrine and Autonomic Systems
dc.subjectCellular and Molecular Neuroscience
dc.subjectCognitive Neuroscience
dc.subjectGeneral Neuroscience
dc.subjectNeuroscience (miscellaneous)
dc.subjectSensory Systems
dc.subjectHuman-Computer Interaction
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectPhysical Sciences
dc.subjectScopolamine-induced amnesia
dc.subjectAlzheimer's disease
dc.subjectOxidative stress
dc.subjectNeuroinflammation
dc.subjectApoptosis
dc.subjectOriganum onites
dc.subjectALZHEIMERS-DISEASE
dc.subjectCYCLOOXYGENASE-2 EXPRESSION
dc.subjectMEMORY IMPAIRMENT
dc.subjectCARVACROL
dc.subjectEXTRACT
dc.subjectBRAIN
dc.subjectMYELOPEROXIDASE
dc.subjectPROTEINSPLUS
dc.subjectAPOPTOSIS
dc.subjectDEFICITS
dc.subjectAlzheimer’s disease
dc.subjectScopolamine-induced amnesia
dc.subjectAlzheimer’s disease
dc.subjectOxidative stress
dc.subjectNeuroinfammation
dc.subjectApoptosis
dc.subjectOriganum onites
dc.titleA multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
dc.typearticle
dspace.entity.typePublication
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local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

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