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Neuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsAtici, Ali Emre; Tamer, Sevil Arabaci; Levent, Hilal Nisva; Eyuboglu, Irem Peker; Ercan, Feriha; Akkiprik, Mustafa; Yegen, Berrak C.
dc.date.accessioned2022-03-14T09:52:26Z
dc.date.available2022-03-14T09:52:26Z
dc.date.issued2022-02
dc.description.abstractSepsis leads to systemic hypotension, disturbed perfusion, inflammation, and tissue toxicity in vital organs. Neuropeptide W (NPW) has modulatory effects in the control of blood pressure and inflammatory processes, implicating a potential beneficial effect against sepsis-induced oxidative damage. Under anesthesia, male Sprague Dawley rats underwent cecal ligation and puncture. Immediately after surgery, either saline or TNF-alpha inhibitor (etanercept; 1 mg/kg) antibiotic (ceftriaxon; 10 mg/kg) combination or NPW (0.1, 1, or 3 mu g/kg) was given subcutaneously, and injections were repeated on the 12th and 24th h. The sham-operated control group was treated with saline at the same time points. All rats were euthanized on the 25th h of surgery. Sepsis resulted in oxidative damage of the brain, heart, lung, liver, and kidney. Elevations in blood urea nitrogen and alkaline phosphatase, showing renal and hepatic dysfunction, were not evident when septic rats were treated with NPW. NPW reduced serum levels of C-reactive protein, corticosterone, and interleukin-6, while histopathologically verified tissue damage in all the studied tissues was ameliorated. NPW treatment suppressed lipid peroxidation in the heart, lung, and brain, and the depleted antioxidant GSH levels of the brain and heart were replenished by NPW. Moreover, sepsis-related neutrophil recruitment to the liver and lung was also suppressed by NPW. Although the survival rate of the rats was not significantly prolonged by NPW, most of these improvements in systemic and local inflammatory events were comparable with those reached by the etanercept and antibiotic combination, suggesting the therapeutic impact of NPW during the acute period of sepsis.
dc.identifier.doi10.1007/s10753-021-01545-5
dc.identifier.eissn1573-2576
dc.identifier.issn0360-3997
dc.identifier.pubmed34564825
dc.identifier.urihttps://hdl.handle.net/11424/243465
dc.identifier.wosWOS:000700558100001
dc.language.isoeng
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.relation.ispartofINFLAMMATION
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsepsis
dc.subjectoxidant injury
dc.subjectneuropeptide W
dc.subjectmulti-organ damage
dc.subjectNF-KAPPA-B
dc.subjectACUTE LUNG INJURY
dc.subjectINNATE IMMUNITY
dc.subjectCECAL LIGATION
dc.subjectORGAN FAILURE
dc.subjectSEPTIC SHOCK
dc.subjectPROTEIN
dc.subjectRECEPTORS
dc.subjectPATHOGENESIS
dc.subjectACTIVATION
dc.titleNeuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis
dc.typearticle
dspace.entity.typePublication
local.avesis.id6aac9858-4ec8-4c22-91a9-794be313f50d
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages18
oaire.citation.titleINFLAMMATION
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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