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ASSOCIATION OF GENETIC POLYMORPHISMS IN THE Matrix Gla Protein (MGP) GENE WITH CORONARY ARTERY DISEASE AND SERUM MGP LEVELS

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dc.contributor.authorLÜLECİ, NİMET EMEL
dc.contributor.authorsKarsli-Ceppioglu, S.; Yazar, S.; Keskin, Y.; Karaca, M.; Luleci, N. E.; Yurdun, T.
dc.date.accessioned2022-03-14T09:17:33Z
dc.date.available2022-03-14T09:17:33Z
dc.date.issued2019-12-21
dc.description.abstractMatrix Gla protein (MGP) is an important regulatory protein for inhibition of calcification in the vessel wall and cartilage. The MGP gene polymorphisms are suspected to increase the risk of extracellular calcification through altering the related gene expression and serum MGP levels. The goal of this study was to examine the correlation between rs4236 (Thr83-Ala), rs12304 (Glu60-X) and rs1800802 (T138-C) polymorphisms of the MGP gene and coronary artery calcification. Serum MGP levels of 168 subjects who had undergone coronary angiography were analyzed along with genotyping of MGP gene polymorphisms. The results indicated that serum MGP levels were significantly associated with rs4236 and rs1800802 polymorphisms of the MGP gene with the occurrence of coronary artery diseases (CAD). Allelic distributions of MGP gene polymorphisms and serum MGP levels, respectively, were not significantly interconnected with the presence of CAD. Our results revealed that serum MGP levels of CAD patients show association with rs4236 and rs1800802 polymorphisms, but serum MGP levels alone do not directly reflect the risk of CAD. The role of MGP genetic variants on formation and progression of arterial calcification should be regarded in cardiovascular diseases.
dc.identifier.doi10.2478/bjmg-2019-0020
dc.identifier.issn1311-0160
dc.identifier.pubmed31942416
dc.identifier.urihttps://hdl.handle.net/11424/242920
dc.identifier.wosWOS:000503866600006
dc.language.isoeng
dc.publisherMACEDONIAN ACAD SCIENCES ARTS
dc.relation.ispartofBALKAN JOURNAL OF MEDICAL GENETICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular disease
dc.subjectCoronary artery disease (CAD)
dc.subjectGenetic polymorphism
dc.subjectMatrix Gla protein (MGP)
dc.subjectCALCIFICATION
dc.subjectMORTALITY
dc.subjectVARIANTS
dc.subjectMEDIA
dc.subjectRISK
dc.titleASSOCIATION OF GENETIC POLYMORPHISMS IN THE Matrix Gla Protein (MGP) GENE WITH CORONARY ARTERY DISEASE AND SERUM MGP LEVELS
dc.typearticle
dspace.entity.typePublication
local.avesis.id9a302eff-3084-4031-be56-98ab6129abea
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ4
oaire.citation.endPage50
oaire.citation.issue2
oaire.citation.startPage43
oaire.citation.titleBALKAN JOURNAL OF MEDICAL GENETICS
oaire.citation.volume22
relation.isAuthorOfPublication54522026-6a5e-4365-9ed6-edc24c702b69
relation.isAuthorOfPublication.latestForDiscovery54522026-6a5e-4365-9ed6-edc24c702b69

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