Publication:
Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?

Simple item page
dc.contributor.authorSANRI, ERKMAN
dc.contributor.authorsKaracabey, Sinan; Sanri, Erkman; Yalcinli, Sercan; Akoglu, Haldun
dc.date.accessioned2022-03-14T08:45:21Z
dc.date.available2022-03-14T08:45:21Z
dc.date.issued2018-04-05
dc.description.abstractObjective: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). Methods: This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine. If an IV treatment in the ED was found indicated by the EP, they selected one of the options in the written departmental migraine treatment protocol. Results: During the study period, 54 patients met the inclusion criteria. The median change in the pain score was significantly different among treatment options (p<0.0001). The median pain score change at the end of the 30 minutes for treatment groups were 7.5 mm (IQR: 7.0-8.0), 5.0 mm (IQR: 4.75-7.0), and 7.0 mm (IQR: 6.0-7.25), respectively (p=0.0002). All three groups were found to be significantly different from each other in the post-hoc analysis. Conclusion: All drugs compared in this study are effective in the relief of migraine headache. However, IV dexketoprofen seems to be faster and more effective than metoclopramide and ibuprofen.
dc.identifier.doi10.12669/pjms.342.13815
dc.identifier.issn1682-024X
dc.identifier.pubmed29805419
dc.identifier.urihttps://hdl.handle.net/11424/242209
dc.identifier.wosWOS:000433113200034
dc.language.isoeng
dc.publisherPROFESSIONAL MEDICAL PUBLICATIONS
dc.relation.ispartofPAKISTAN JOURNAL OF MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDexketoprofen
dc.subjectIbuprofen
dc.subjectMetoclopramide
dc.subjectMigraine
dc.subjectEMERGENCY-DEPARTMENT TREATMENT
dc.subjectRANDOMIZED CLINICAL-TRIAL
dc.subjectINTRAVENOUS METOCLOPRAMIDE
dc.subjectUNITED-STATES
dc.subjectHEADACHE
dc.subjectPROCHLORPERAZINE
dc.subjectDIPHENHYDRAMINE
dc.subjectMETAANALYSIS
dc.subjectPARACETAMOL
dc.subjectKETOROLAC
dc.titleWhich is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
dc.typearticle
dspace.entity.typePublication
local.avesis.idb3d8ce0a-74ca-4206-ad40-42e7f212aab4
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ4
oaire.citation.endPage423
oaire.citation.issue2
oaire.citation.startPage418
oaire.citation.titlePAKISTAN JOURNAL OF MEDICAL SCIENCES
oaire.citation.volume34
relation.isAuthorOfPublication8e7070d2-5627-4e08-afd8-2a8d0e8af68c
relation.isAuthorOfPublication.latestForDiscovery8e7070d2-5627-4e08-afd8-2a8d0e8af68c

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Karacabey et al. - 2018 - Which is more effective for the treatment of Acute.pdf
Size:
383.72 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs