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Is Perineural Invasio (PN) a Determinant of Disease Free Survival in Early Stage Colorectal Cancer?

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dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsOzturk, Mehmet Akif; Dane, Faysal; Karagoz, Sila; Tural, Deniz; Selcukbiricik, Fatih; Demirelli, Fuat; Buyukunal, Evin; Ozguroglu, Mustafa; Turna, Hande; Erdamar, Sibel; Celikel, Cigdem Ataizi; Bozkurtlar, Emine Bas; Yumuk, Perran Fulden; Mandel, Nil Molinas; Turhal, Nazim Serdar; Serdengecti, Suheyla
dc.date.accessioned2022-03-13T12:50:32Z
dc.date.available2022-03-13T12:50:32Z
dc.date.issued2015
dc.description.abstractBackground/Aims: The prognostic importance of perineural invasion (PN) in colorectal cancer (CRC) is unclear. The aim of this study to find out whether the PN was an independent stratification factor of postoperative relapse in curatively resected high-risk stage II & III CRC patients who were treated with adjuvant therapy. Methodology: Data of patients with high risk stage II & all stage III CRCs treated with adjuvant chemotherapy were retrospectively analyzed. Pathological features of final surgical specimen were noted. Disease-free survival was determined by Kaplan-Meier estimator, with differences determined by multivariate analysis using the Cox multiple hazards model. Results were compared using the log-ranktest. Results: PN was found to be positive in 26% in the files of 593 eligible patients. In 21% of the reports PN status was not reported. Presence of PN in the resected primary tumors did not have independent effect on DFS. Further analyses for importance of PN on DFS of colon or rectal cancers did not show any effect. Conclusions: This study had failed to demonstrate any prognostic effect of PN for DFS in surgically resected stage II and III CRC patients who received adjuvant treatments.
dc.identifier.doi10.5754/hge13938
dc.identifier.issn0172-6390
dc.identifier.pubmed25911868
dc.identifier.urihttps://hdl.handle.net/11424/238384
dc.identifier.wosWOS:000352115700012
dc.language.isoeng
dc.publisherH G E UPDATE MEDICAL PUBLISHING S A
dc.relation.ispartofHEPATO-GASTROENTEROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPerineural invasion
dc.subjectColorectal cancer
dc.subjectAdjuvant
dc.subjectSurvival
dc.subjectPrognosis
dc.subjectPROGNOSTIC-SIGNIFICANCE
dc.subjectCURATIVE RESECTION
dc.subjectNEURAL INVASION
dc.subjectRISK
dc.subjectRADIOTHERAPY
dc.subjectRECURRENCE
dc.subjectCARCINOMA
dc.subjectRELAPSE
dc.subjectCOLON
dc.titleIs Perineural Invasio (PN) a Determinant of Disease Free Survival in Early Stage Colorectal Cancer?
dc.typearticle
dspace.entity.typePublication
local.avesis.idd003c5a5-d131-4e7f-b59c-87aa1a216491
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage64
oaire.citation.issue137
oaire.citation.startPage59
oaire.citation.titleHEPATO-GASTROENTEROLOGY
oaire.citation.volume62
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

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