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3D printing of chitosan/ poly(vinyl alcohol) hydrogel containing synthesized hydroxyapatite scaffolds for hard-tissue engineering

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dc.contributor.authorKARTAL, İLYAS
dc.contributor.authorsErgul, Necdet Mekki; Unal, Semra; Kartal, Ilyas; Kalkandelen, Cevriye; Ekren, Nazmi; Kilic, Osman; Chi-Chang, Lin; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:38:35Z
dc.date.available2022-03-12T22:38:35Z
dc.date.issued2019
dc.description.abstractIn recent years, 3D printed scaffolds becoming a widespread tool, which supports the repair mechanism of natural tissues. In order to support this knowledge, we used 3D printing methods to fabricated Chitosan (CH)/poly(vinyl alcohol)(PVA)-based scaffolds contains with a various ratio of hydroxyapatite (HA) (2.5, 5, 10, and 15 wt%). These composited scaffolds were further characterized for their chemical, morphological, mechanical, and biocompatibility properties. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), swelling test, and compressive strength test were performed to reveal structural, mechanical and chemical characteristics of scaffolds. Among others, 15 wt% HA contained group demonstrated significantly superior and beneficial features in printing quality. Also, the results reveal that scaffolds have similar elastic modulus to natural bone. Bone morphogenetic protein-2 (BMP-2) protein was added to the most successful mechanically produced sample. As a result, it was shown that Chitosan/PVA/HA (15 wt%) with BMP-2 tissue scaffold could form a three-dimensional natural extracellular scaffold suitable for human mesenchymal stem cells. Altogether, these results show that hydroxyapatite added scaffolds produced may be a promising approach for bone tissue engineering applications.
dc.identifier.doi10.1016/j.polymertesting.2019.106006
dc.identifier.eissn1873-2348
dc.identifier.issn0142-9418
dc.identifier.urihttps://hdl.handle.net/11424/235677
dc.identifier.wosWOS:000499945200009
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofPOLYMER TESTING
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomaterials
dc.subjectHydrogels
dc.subject3D printing
dc.subjectHard-tissue engineering
dc.subjectNANOCOMPOSITE
dc.title3D printing of chitosan/ poly(vinyl alcohol) hydrogel containing synthesized hydroxyapatite scaffolds for hard-tissue engineering
dc.typearticle
dspace.entity.typePublication
local.avesis.ide57d8b5f-093e-4cfd-87f6-4d7e2f9b56a4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber106006
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.titlePOLYMER TESTING
oaire.citation.volume79
relation.isAuthorOfPublicationa6f9504d-71e4-45cb-9fbe-05e6a695d03f
relation.isAuthorOfPublication.latestForDiscoverya6f9504d-71e4-45cb-9fbe-05e6a695d03f

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