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Single nucleotide polymorphisms in IL-1A RS1800587, IL-1B RS1143634 and vitamin D receptor rs731236 in stage III grade B/C periodontitis

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dc.contributor.authorÖZTÜRK ÖZENER, HAFİZE
dc.contributor.authorASLAN, BEGÜM
dc.contributor.authorAĞRALI, ÖMER BİRKAN
dc.contributor.authorULUCAN, KORKUT
dc.contributor.authorYILDIRIM, HATİCE SELİN
dc.contributor.authorKURU, LEYLA
dc.contributor.authorsOzener H., ASLAN B., Eken B. F., AĞRALI Ö. B., Yildrim H. S., Altunok E. C., ULUCAN K., KURU L.
dc.date.accessioned2023-04-03T06:13:05Z
dc.date.available2023-04-03T06:13:05Z
dc.date.issued2022-06-01
dc.description.abstractThe purpose of the study is to determine the prevalence of interleukin (IL)-1A (rs1800587), IL-1B (rs1143634) and vitamin D receptor (VDR) (TaqI, rs731236) gene polymorphisms in the Turkish population and their association with Stage III Grade B/C periodontitis. Systemically and periodontally healthy individuals (N = 100) and Stage III Grade B/C periodontitis patients (N=100) based on clinical and radiographic examination were included in this research. Clinical attachment level, probing depth, bleeding on probing, plaque and gingival indices of the subjects were measured. Genotyping of IL-1A (rs1800587), IL-1B (rs1143634) and VDR (rs731236) polymorphisms was conducted by Real Time PCR. Allelic and genotypic distributions of IL-1A (rs1800587) gene polymorphism were not associated with periodontitis (p > 0.05). In IL-1B (rs1143634) gene polymorphism, the C allele was detected more frequently in healthy individuals compared with the periodontitis patients (p=0.045). CC genotype and C allele in VDR (rs731236) gene polymorphism was higher in periodontitis patients (p=0.031, p=0.034, respectively). In comparison with Grade B periodontitis patients and healthy subjects, CC genotype and C allele were observed more frequently in the Grade B periodontitis in terms of alleles (C/T) and genotypes for VDR (rs731236) polymorphism (p=0.024, p=0.008, respectively). This study presents that the VDR (rs731236) polymorphism are associated with enhanced susceptibility to Stage III periodontitis in the Turkish population. Furthermore, VDR (rs731236) polymorphism may be used as an identification criteria to discriminate Grade B and Grade C in Stage III periodontitis.
dc.identifier.citationOzener H., ASLAN B., Eken B. F., AĞRALI Ö. B., Yildrim H. S., Altunok E. C., ULUCAN K., KURU L., "Single nucleotide polymorphisms in IL-1A RS1800587, IL-1B RS1143634 and vitamin D receptor rs731236 in stage III grade B/C periodontitis", BALKAN JOURNAL OF MEDICAL GENETICS, cilt.25, sa.1, ss.51-60, 2022
dc.identifier.doi10.2478/bjmg-2022-0005
dc.identifier.endpage60
dc.identifier.issn1311-0160
dc.identifier.issue1
dc.identifier.startpage51
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/67233a42-81c3-4143-85ee-2a6b5899609e/file
dc.identifier.urihttps://hdl.handle.net/11424/288050
dc.identifier.volume25
dc.language.isoeng
dc.relation.ispartofBALKAN JOURNAL OF MEDICAL GENETICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectMedical Genetics
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectGENETİK VE KALITIM
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGENETICS & HEREDITY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectGenetik (klinik)
dc.subjectMoleküler Biyoloji
dc.subjectGenetik
dc.subjectGenetics (clinical)
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectInterleukin-1alpha
dc.subjectInterleukin-1beta
dc.subjectVitamin D receptor
dc.subjectPeriodontitis
dc.subjectPolymorphism
dc.subjectINTERLEUKIN-1 GENE POLYMORPHISMS
dc.subjectPERI-IMPLANT DISEASES
dc.subjectAGGRESSIVE PERIODONTITIS
dc.subjectSUSCEPTIBILITY TEST
dc.subjectASSOCIATION
dc.subjectCLASSIFICATION
dc.subjectCLUSTER
dc.subjectSAMPLE
dc.subjectRISK
dc.titleSingle nucleotide polymorphisms in IL-1A RS1800587, IL-1B RS1143634 and vitamin D receptor rs731236 in stage III grade B/C periodontitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id67233a42-81c3-4143-85ee-2a6b5899609e
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