Publication:
Outcome of rectal and sigmoid carcinoma patients receiving adjuvant chemoradiotherapy in marmara university hospital

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dc.contributor.authorYUMUK, PERRAN FULDEN
dc.contributor.authorsYumuk, PF; Abacioglu, U; Caglar, H; Gumus, M; Sengoz, M; Turhal, NS
dc.date.accessioned2022-03-12T17:16:23Z
dc.date.available2022-03-12T17:16:23Z
dc.date.issued2003
dc.description.abstractAdjuvant chemoradiotherapy is the standard treatment in resected stage II/III rectosigmoid carcinoma. We report a retrospective analysis of 33 patients who received adjuvant chemoradiotherapy. Patients received 5-fluorouracil (375mg/m(2)/day x 5days) and calcium leucovorin (20mg/m(2)/day x 5days), q4weeks, two courses before and two courses after radiotherapy. The 5-fluorouracil dose was reduced to 225mg/m(2)/day given continuously as protracted short-term infusion on the first and last 3 days during radiotherapy. Radiotherapy was started at 7th week and 45-50.4 Gy was given to pelvic region. Median age was 63 years. Median follow-up was 38 months starting from the operation date. Four-year local and distant control rates were 78% and 69%, respectively. Four-year disease-free survival and overall survival were 60% and 62%, respectively. Protracted short-term infusion of 5-fluorouracil during pelvic irradiation is a safe treatment modality. Further studies are needed to improve the local control of high-risk rectal and sigmoid carcinomas.
dc.identifier.doi10.1179/joc.2003.15.6.603
dc.identifier.eissn1973-9478
dc.identifier.issn1120-009X
dc.identifier.pubmed14998088
dc.identifier.urihttps://hdl.handle.net/11424/227555
dc.identifier.wosWOS:000189120000014
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofJOURNAL OF CHEMOTHERAPY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectrectal neoplasms
dc.subjectsigmoid neoplasms
dc.subjectcombined modality therapy
dc.subjectradiotherapy
dc.subjectadjuvant chemotherapy
dc.subject5-fluorouracil
dc.subjectRADIATION-THERAPY
dc.subjectRANDOMIZED-TRIAL
dc.subjectCANCER
dc.subjectCHEMOTHERAPY
dc.subjectRADIOTHERAPY
dc.subjectFLUOROURACIL
dc.subjectPATTERNS
dc.subjectSTAGE
dc.titleOutcome of rectal and sigmoid carcinoma patients receiving adjuvant chemoradiotherapy in marmara university hospital
dc.typearticle
dspace.entity.typePublication
local.avesis.idf02d008b-2dad-4992-b470-1ac5e676e883
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
oaire.citation.endPage606
oaire.citation.issue6
oaire.citation.startPage603
oaire.citation.titleJOURNAL OF CHEMOTHERAPY
oaire.citation.volume15
relation.isAuthorOfPublication4e7b3d69-6d73-4c60-89e4-d6fddfddd2aa
relation.isAuthorOfPublication.latestForDiscovery4e7b3d69-6d73-4c60-89e4-d6fddfddd2aa

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