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Increased Noradrenaline Levels in the Rostral Pons can be Reversed by M1 Antagonist in a Rat Model of Post-traumatic Stress Disorder

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dc.contributor.authorAYDIN OMAY, BANU
dc.contributor.authorsTerzioglu, Berna; Kaleli, Melisa; Aydin, Banu; Ketenci, Sema; Cabadak, Hulya; Goren, M. Zafer
dc.date.accessioned2022-03-12T18:09:25Z
dc.date.available2022-03-12T18:09:25Z
dc.date.issued2013
dc.description.abstractThe dysregulation of hypothalamic-pituitary-adrenal axis and noradrenergic, serotonergic and glutamatergic systems are thought to be involved in the pathophysiology of post-traumatic stress disorder. The effect of selective M1 muscarinic receptor antagonist, pirenzepine on anxiety indices was investigated by using elevated plus maze, following exposure to trauma reminder. Upon receiving the approval of ethics committee, Sprague-Dawley rats were exposed to dirty cat litter (trauma) for 10 min and 1 week later, the rats confronted to a trauma reminder (clean litter). The rats also received intraperitoneal pirenzepine (1 or 2 mg/kg/day) or saline for 8 days. Noradrenaline (NA) concentration in the rostral pons was analyzed by HPLC with electrochemical detection. The anxiety indices of the rats subjected to the trauma reminder were increased when compared to control rats (p < 0.05). Pirenzepine treatment in traumatized rats displayed similar anxiety indices of non-traumatized rats treated with physiological saline. Although freezing time was prolonged with pirenzepine in traumatized groups the change was not found statistically significant. The NA level was 1.5 +/- A 0.1 pg/mg in non-traumatized rats and increased to 2.4 +/- A 0.2 pg/mg in traumatized rats. Bonferroni post hoc test revealed that the NA content of the rostral pons of the traumatized rats treated with physiological saline was significantly higher than the content of other groups (p < 0.01). We conclude that NA content in the rostral pons increases in respect to confrontation to a trauma reminder which can be reversed by M1 antagonist pirenzepine indicating the roles of M1 receptors.
dc.identifier.doi10.1007/s11064-013-1076-2
dc.identifier.eissn1573-6903
dc.identifier.issn0364-3190
dc.identifier.pubmed23681605
dc.identifier.urihttps://hdl.handle.net/11424/231277
dc.identifier.wosWOS:000320878200020
dc.language.isoeng
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.relation.ispartofNEUROCHEMICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPirenzepine
dc.subjectElevated plus maze
dc.subjectMuscarinic
dc.subjectLocus ceruleus
dc.subjectAnxiety
dc.subjectHPLC
dc.subjectMUSCARINIC ACETYLCHOLINE-RECEPTORS
dc.subjectCORTICOTROPIN-RELEASING-FACTOR
dc.subjectPITUITARY-ADRENOCORTICAL AXIS
dc.subjectLOCUS-COERULEUS
dc.subjectANIMAL-MODEL
dc.subjectBEHAVIORAL DEPRESSION
dc.subjectBRAIN-STEM
dc.subjectNOREPINEPHRINE
dc.subjectNUCLEUS
dc.subjectANXIETY
dc.titleIncreased Noradrenaline Levels in the Rostral Pons can be Reversed by M1 Antagonist in a Rat Model of Post-traumatic Stress Disorder
dc.typearticle
dspace.entity.typePublication
local.avesis.iddef55279-da3a-47b4-aa07-c0231d178aec
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage1733
oaire.citation.issue8
oaire.citation.startPage1726
oaire.citation.titleNEUROCHEMICAL RESEARCH
oaire.citation.volume38
relation.isAuthorOfPublicationaf9e48cc-cef6-4af2-bdb7-5b424aadfc2b
relation.isAuthorOfPublication.latestForDiscoveryaf9e48cc-cef6-4af2-bdb7-5b424aadfc2b

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