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Long-term neuromusculoskeletal side effects and quality of life in nasopharyngeal cancer patients receiving radiochemotherapy

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsKefeli, Aysegul Ucuncu; Sanal-Toprak, Canan; Asedov, Ruslan; Ozen, Zeynep; Akyuz, Gulseren; Dane, Faysal; Atasoy, Beste M.
dc.date.accessioned2022-03-12T22:44:18Z
dc.date.available2022-03-12T22:44:18Z
dc.date.issued2020
dc.description.abstractAim In this study, we aimed to evaluate the neuromusculoskeletal late side effects and their impact on the quality of life of patients with nasopharyngeal carcinoma treated with radiochemotherapy. Patients and methods Twenty-seven patients were included. The mean follow-up was 61 months (range, 18-111 months). The median external radiotherapy dose applied to the nasopharynx and primary tumor was 70 Gy (range, 61-73 Gy). The mean dose received by the temporomandibular joint in the dose-volume histograms of these patients was 60.7 Gy. The maximal doses of the muscles responsible for cervical motion in different ranges were greater than 60 Gy, and the mean doses were greater than 40 Gy in the muscle groups, except for the extensor muscles. Results Two patients had brachial plexus involvement, while 89% of the patients had restriction in flexion and extension movements. Of the patients, 52% had trismus. There was a significant correlation between extension restriction and general heath score and the physical subscale of the quality-of-life questionnaire (p = 0.01). There was also a correlation between trismus and pain killer usage (p = 0.004). Conclusion This is the first study to analyze long-term muscle and nerve toxicity and their correlation between doses in nasopharyngeal cancer patients following radiochemotherapy. Despite the advances in radiotherapy techniques, it is necessary to pay attention to the doses of the nerves and muscles for late effects.
dc.identifier.doi10.1007/s00405-020-05932-w
dc.identifier.eissn1434-4726
dc.identifier.issn0937-4477
dc.identifier.pubmed32236708
dc.identifier.urihttps://hdl.handle.net/11424/236416
dc.identifier.wosWOS:000522696500002
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNasopharyngeal cancer
dc.subjectRadiotherapy
dc.subjectBrachial plexus
dc.subjectLate effects
dc.subjectNeuromusculoskeletal
dc.subjectPLEXUS-ASSOCIATED NEUROPATHY
dc.subjectRADIATION-INDUCED TRISMUS
dc.subjectNECK-CANCER
dc.subjectCONSERVATIVE SURGERY
dc.subjectHEAD
dc.subjectTHERAPY
dc.subjectRADIOTHERAPY
dc.subjectCARCINOMA
dc.subjectCOMPLICATIONS
dc.subjectQLQ-C30
dc.titleLong-term neuromusculoskeletal side effects and quality of life in nasopharyngeal cancer patients receiving radiochemotherapy
dc.typearticle
dspace.entity.typePublication
local.avesis.idec221e65-4f30-4a23-a455-77e082891645
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage2333
oaire.citation.issue8
oaire.citation.startPage2325
oaire.citation.titleEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
oaire.citation.volume277
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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