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Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches

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dc.contributor.authorEMRE, GİZEM
dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsZengin G., EMRE G., Mollica A., Haznedaroglu M. Z. , DOĞAN A., Aktumsek A.
dc.date.accessioned2022-11-10T17:18:05Z
dc.date.available2022-11-10T17:18:05Z
dc.date.issued2017-09-01
dc.description.abstractThis study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. Enzyme inhibitory effects were tested against cholinesterases, tyrosinase, amylase, glucosidase and lipase. Total phenolic contents were ranged from 20.52 mgGAE/g extract (B. croceum methanol extract) to 41.13 mgGAE/g extract (A. phrygia methanol extract). Generally, methanol and water extracts showed the strongest antioxidant abilities, while the ethyl acetate extracts had the most promising enzyme inhibitory effects. HPLC analysis revealed the abundance of some phenolics including rutin, quercetin, sinapic acid and chlorogenic acid, respectively. These components were also assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. Overall, these species could be suggested as valuable sources of natural-bioactive agents for developing new functional, pharmacological and health promoting ingredients. (C) 2017 Elsevier Ltd. All rights reserved.
dc.identifier.citationZengin G., EMRE G., Mollica A., Haznedaroglu M. Z. , DOĞAN A., Aktumsek A., "Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches", FOOD AND CHEMICAL TOXICOLOGY, cilt.107, ss.597-608, 2017
dc.identifier.doi10.1016/j.fct.2017.03.037
dc.identifier.endpage608
dc.identifier.issn0278-6915
dc.identifier.startpage597
dc.identifier.urihttps://hdl.handle.net/11424/283084
dc.identifier.volume107
dc.language.isoeng
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectGıda Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectPharmacology and Therapeutics
dc.subjectProfessional Sciences
dc.subjectPharmaceutical Toxicology
dc.subjectAgricultural Sciences
dc.subjectAgriculture
dc.subjectFood Engineering
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFOOD SCIENCE & TECHNOLOGY
dc.subjectAGRICULTURAL SCIENCES
dc.subjectAgriculture & Environment Sciences (AGE)
dc.subjectTOXICOLOGY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectToksikoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectSağlık, Toksikoloji ve Mutajenez
dc.subjectYemek bilimi
dc.subjectFizik Bilimleri
dc.subjectToxicology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectFood Science
dc.subjectPhysical Sciences
dc.subjectAchiella phrygia
dc.subjectBupleurum croceum
dc.subjectBioactive compounds
dc.subjectNatural agents
dc.subjectTurkey
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectMILLEFOLIUM L.
dc.subjectBIOLOGICAL-ACTIVITIES
dc.subjectCHLOROGENIC ACIDS
dc.subjectCRYSTAL-STRUCTURE
dc.subjectPOTENTIAL SOURCES
dc.subjectASPHODELINE TAXA
dc.subjectNATURAL AGENTS
dc.subjectALPHA-AMYLASE
dc.subjectESSENTIAL OIL
dc.subjectAchiella phrygia
dc.subjectBupleurum croceum
dc.subjectBioactive compounds
dc.subjectNatural agents
dc.subjectTurkey
dc.titleBioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
dc.typearticle
dspace.entity.typePublication
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local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication056ad19f-5117-4589-98e2-80d0469dc104
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery056ad19f-5117-4589-98e2-80d0469dc104

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