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A 10-day mild treadmill exercise performed before an epileptic seizure alleviates oxidative injury in the skeletal muscle and brain tissues of the rats

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dc.contributor.authorKAYA, ÖZLEM TUĞÇE
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorYILDIRIM, ALPER
dc.contributor.authorsArabaci -Tamer S., KAYA Ö. T., YÜKSEL M., YILDIRIM A., YEGEN B.
dc.date.accessioned2023-02-20T10:22:42Z
dc.date.available2023-02-20T10:22:42Z
dc.date.issued2022-01-01
dc.description.abstract© 2022 Marmara University Press, All Rights Reserved.Objective: Epileptic seizures may cause skeletal muscle injury and memory dysfunctions. The present study was aimed to investigate the possible protective effects of exercising prior to seizure on seizure-induced oxidative injury in the skeletal muscle and brain. Materials and Methods: Sprague-Dawley male rats were assigned as non-exercise (n=16) and exercise groups (n=16). Following a 3-day exercise training, exercise protocol (30 min) was performed on a treadmill for 10 days, while control rats had no exercise. On the 11th day, the epileptic seizure was induced by a single intraperitoneal injection of pentylenetetrazol (PTZ) (45 mg/kg), while the control groups were injected with saline. Passive-avoidance test was initially performed before PTZ/saline injection and repeated 72 h later for the assessment of memory function. Brain and gastrocnemius muscles were taken for histological assessments and to determine the levels of malondialdehyde (MDA) and glutathione (GSH), myeloperoxidase (MPO) activity and luminal – and lucigenin – enhanced chemiluminescence levels. Results: Exercise training alone increased the formation of reactive oxygen species and elevated the antioxidant GSH capacity of the muscle tissue in the control rats, but these effects were not observed in the muscles of the exercised rats induced with a PTZ-seizure. On the other hand, short-term exercise alone had no effect on the basal oxidative parameters of the brain tissues. Prior exercise did not alter the average seizure scores or memory performances when compared to non-exercised groups, but suppressed the PTZ-induced elevations in MDA and chemiluminescence levels as well as MPO activity in the brain. Conclusion: A 10-day mild treadmill exercise reduced the oxidative brain damage due to a single seizure-induced excitotoxicity and exerted a preconditioning effect on the skeletal muscles exposed to tonic-clonic contractions.
dc.identifier.citationArabaci -Tamer S., KAYA Ö. T., YÜKSEL M., YILDIRIM A., YEGEN B., "A 10-day mild treadmill exercise performed before an epileptic seizure alleviates oxidative injury in the skeletal muscle and brain tissues of the rats", Marmara Medical Journal, cilt.35, sa.1, ss.1-9, 2022
dc.identifier.doi10.5472/marumj.1056192
dc.identifier.endpage9
dc.identifier.issn1019-1941
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/69869df9-ba42-4b74-ad5b-d7ae367a1cb5/file
dc.identifier.urihttps://hdl.handle.net/11424/286576
dc.identifier.volume35
dc.language.isoeng
dc.relation.ispartofMarmara Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectFamily Practice
dc.subjectFundamentals and Skills
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectInternal Medicine
dc.subjectAssessment and Diagnosis
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectEpileptic seizure
dc.subjectExercise
dc.subjectOxidative damage
dc.subjectMemory dysfunction
dc.subjectSkeletal muscle
dc.subjectPILOCARPINE-INDUCED SEIZURES
dc.subjectPHYSICAL-EXERCISE
dc.subjectCOGNITIVE IMPAIRMENT
dc.subjectNITRIC-OXIDE
dc.subjectSTRESS
dc.subjectDAMAGE
dc.subjectANTIOXIDANTS
dc.subjectINFLAMMATION
dc.subjectMEMORY
dc.subjectLIGHT
dc.subjectEpileptic seizure
dc.subjectExercise
dc.subjectOxidative damage
dc.subjectMemory dysfunction
dc.subjectSkeletal muscle
dc.titleA 10-day mild treadmill exercise performed before an epileptic seizure alleviates oxidative injury in the skeletal muscle and brain tissues of the rats
dc.typearticle
dspace.entity.typePublication
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local.indexed.atSCOPUS
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