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Neuroprotective effect of regular swimming exercise on calretinin-positive striatal neurons of Parkinsonian rats

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dc.contributor.authorBORACI, HATİCE
dc.contributor.authorsBoraci, H.; Kirazli, O.; Gulhan, R.; Sercan, D. Yildiz; Sehirli, U. S.
dc.date.accessioned2022-03-12T22:40:00Z
dc.date.available2022-03-12T22:40:00Z
dc.date.issued2020
dc.description.abstractIn Parkinson's disease (PD), physical therapy is one of the mainstays of supportive treatment modalities. This study focused on the neuroprotective effect of regular exercise on striatal calretinin positive interneurons in a rat model of PD. 6-hydroxydopamine (6-OHDA) was injected unilaterally into the medial forebrain bundle of Wistar rats. 6-OHDA lesioned (Parkinsonian) and unlesioned (control) rats were divided into sedentary and exercise groups. Exercise groups had daily swimming sessions for 30 min for 6 weeks. After 6-OHDA injections, an apomorphine-induced rotation test was performed (0.05 mg/kg, subcutaneous) at the 3rd and 6th weeks. At the end of the 6th week, brains were removed following transcardiac perfusion. The brain sections were stained immunohistochemically for tyrosine hydroxylase and calretinin reactivity. The number of rotations was significantly lower in Parkinsonian exercise group compared to Parkinsonian sedentary group at the 6th week (p = 0.024) and there was significant difference between Parkisonian sedentary groups at the 3rd and 6th weeks (p < 0.002). The calretinin positive interneurons significantly increased in the Parkinsonian exercise group compared to Parkinsonian sedentary group (p = 0.0003) and control exercise group (p < 0.0001). To conclude, the swimming exercise led to a striking increment of calretinin positive interneurons in the striatum of Parkinsonian rat. These findings indicated that the neuroprotective mechanism of exercise increased the number of striatal calretinin positive interneurons that might generate new approaches for the mechanism of neuroprotection. We concluded that striatal calretinin positive interneurons have an important role in the neuroprotective mechanisms of exercise in PD.
dc.identifier.doi10.1007/s12565-020-00538-y
dc.identifier.eissn1447-073X
dc.identifier.issn1447-6959
dc.identifier.pubmed32200530
dc.identifier.urihttps://hdl.handle.net/11424/235888
dc.identifier.wosWOS:000521064100001
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofANATOMICAL SCIENCE INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCalretinin
dc.subjectParkinson's disease
dc.subjectRat
dc.subjectStriatum
dc.subjectSwimming exercise
dc.subjectTREADMILL EXERCISE
dc.subjectDIABETIC-RATS
dc.subjectGABAERGIC INTERNEURONS
dc.subjectGROWTH-FACTOR
dc.subjectEXPRESSION
dc.subjectMODEL
dc.subjectCALCIUM
dc.subjectDISEASE
dc.subjectMOTOR
dc.subjectORGANIZATION
dc.titleNeuroprotective effect of regular swimming exercise on calretinin-positive striatal neurons of Parkinsonian rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id30f20f93-343f-4baa-bf7f-91388ad0c0d6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
local.journal.quartileQ3
oaire.citation.endPage439
oaire.citation.issue4
oaire.citation.startPage429
oaire.citation.titleANATOMICAL SCIENCE INTERNATIONAL
oaire.citation.volume95
relation.isAuthorOfPublicationdb6065d9-ac04-4645-b1f8-fe05e925c462
relation.isAuthorOfPublication.latestForDiscoverydb6065d9-ac04-4645-b1f8-fe05e925c462

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