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Synthesis, characterization and biological evaluation of thioureas, acylthioureas and 4-thiazolidinones as anticancer and antiviral agents

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dc.contributor.authorÖZSAVCI, DERYA
dc.contributor.authorsKulabas, Necla; Ozakpinar, Ozlem Bingol; Ozsavci, Derya; Leyssen, Pieter; Neyts, Johan; Kucukguzel, Ilkay
dc.date.accessioned2022-03-14T08:23:27Z
dc.date.available2022-03-14T08:23:27Z
dc.date.issued2017-04-01
dc.description.abstractIn this study, thiourea derivatives [1-4] were synthesized by using 2-amino-4-substituted pyridine compounds and these compounds have been used as the starting materials for synthesis of 2-imino-1,3-thiazolidin-4-one ring [5, 6]. Two different procedures for 4-thiazolidinone ring closure and synthesis method were optimized. The synthesized compounds were identified by the help of elemental analysis, IR, H-1-NMR, C-13-NMR and mass spectral data while the purities of them were proved with TLC. Synthesized compounds were evaluated for their antiviral and anticancer activity. Antiviral activity against Murine norovirus, Yellow fever, Enterovirus and Chikungunya strains of the test compounds were investigated and EC 50 values of these compounds were determined higher than 0,3 mu M. Cytotoxicity of test compounds was examined on NIH3T3 cell line. When the anticancer activity of test compounds was examined against PC-3, A549, HeLa, HT-29, MCF-7, SJSA1 and K562 cell lines, the percent proliferation values of these compounds were observed over 61% for all cell lines.
dc.identifier.doi10.12991/marupj.300913
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/241685
dc.identifier.wosWOS:000411289700022
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcylthioureas
dc.subjectanticancer
dc.subjectantiviral
dc.subjecttautomerism
dc.subjectthiourea
dc.subject2-amino-1,3-thiazol-4-one
dc.subject2-imino-1,3-thiazolidin-4-one
dc.subjectDRUG DISCOVERY
dc.subjectN,N-DISUBSTITUTED THIOUREAS
dc.subjectTHIAZOLIDINONE DERIVATIVES
dc.subjectNONNUCLEOSIDE INHIBITORS
dc.subjectANTITUBERCULOSIS AGENTS
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectCYTOTOXIC ACTIVITIES
dc.subjectACYL THIOUREAS
dc.subjectANALOGS
dc.subjectMOIETY
dc.titleSynthesis, characterization and biological evaluation of thioureas, acylthioureas and 4-thiazolidinones as anticancer and antiviral agents
dc.typearticle
dspace.entity.typePublication
local.avesis.id111a140e-fa8f-4328-86e3-c2649808e345
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages14
oaire.citation.endPage384
oaire.citation.issue2
oaire.citation.startPage371
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume21
relation.isAuthorOfPublication68ec1222-da29-4568-a8e5-56ebd6b48020
relation.isAuthorOfPublication.latestForDiscovery68ec1222-da29-4568-a8e5-56ebd6b48020

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