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Effect of brain acetylcholine depletion on bicuculline-induced cardiovascular and locomotor responses

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dc.contributor.authorGÜLHAN, REZZAN
dc.contributor.authorsTellioglu, T; Aker, R; Oktay, S; Onat, F
dc.date.accessioned2022-03-12T16:56:02Z
dc.date.available2022-03-12T16:56:02Z
dc.date.issued1997
dc.description.abstractBoth GABAergic and cholinergic systems are involved in central cardiovascular regulation. Previous studies have shown that GABA(A) receptor antagonists cause increases in blood pressure, heart rate and locomotor activity. In this study, we examined the role of the depletion of brain acetylcholine on the cardiovascular responses and locomotor activity induced by bicuculline methiodide in conscious Sprague-Dawley rats. The doses of 0.3 and 0.5 nmol of intracerebroventricular bicuculline methiodide produced increases in blood pressure, heart rate and locomotor activity. The dose of 18 nmol of hemicholinium-3 to deplete brain acetylcholine was given intracerebroventricularly one hour prior to bicuculline methiodide. The presser responses to bicuculline methiodide in animals pretreated with the hemicholinium-3 were higher than those seen in saline-pretreated groups, bur locomotor activity and heart rate responses to bicuculline methiodide remained unchanged in hemicholinium-3 pretreatment group. On the other hand, high dose of bicuculline methiodide (0.5 nmol) caused convulsions in some animals pretreated with hemicholinium-3 whereas bicuculline methiodide, alone, did nor cause any seizure activity. In conclusion, it seems likely that endogenous brain acetylcholine could be a modulator of GABA(A) receptor-mediated blood pressure control.
dc.identifier.doi10.3109/00207459708988470
dc.identifier.issn0020-7454
dc.identifier.pubmed9134452
dc.identifier.urihttps://hdl.handle.net/11424/226641
dc.identifier.wosWOS:A1997WW41100001
dc.language.isoeng
dc.publisherGORDON BREACH SCI PUBL LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGABA(A) receptor
dc.subjectacetylcholine
dc.subjectcardiovascular function
dc.subjectlocomotor activity
dc.subjectBASAL FOREBRAIN
dc.subjectPOSTERIOR HYPOTHALAMUS
dc.subjectGABAERGIC NEURONS
dc.subjectGABA ANTAGONISTS
dc.subjectBLOOD-PRESSURE
dc.subjectRAT
dc.subjectRECEPTORS
dc.subjectPHYSOSTIGMINE
dc.subjectHYPERTENSION
dc.subjectHIPPOCAMPUS
dc.titleEffect of brain acetylcholine depletion on bicuculline-induced cardiovascular and locomotor responses
dc.typearticle
dspace.entity.typePublication
local.avesis.id4cebc0f4-aec9-44d3-acbd-689e08283fa2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage152
oaire.citation.issue3-4
oaire.citation.startPage143
oaire.citation.titleINTERNATIONAL JOURNAL OF NEUROSCIENCE
oaire.citation.volume89
relation.isAuthorOfPublicationc44fef14-869d-4c28-a766-5e080b17c687
relation.isAuthorOfPublication.latestForDiscoveryc44fef14-869d-4c28-a766-5e080b17c687

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