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Therapeutic effects of momordica charantia L. Ethanolic extract on acetic acid-induced ulcerative colitis in rats

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorKAYA, ÖZLEM TUĞÇE
dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsÖZBEYLİ D., ŞEN A., Aykac A., Terali K., Cilingir-Kaya Ö. T., ŞENKARDEŞ İ., Sener G.
dc.date.accessioned2023-06-02T07:12:11Z
dc.date.available2023-06-02T07:12:11Z
dc.date.issued2021-01-01
dc.description.abstract© 2021 European Journal of Biology. All rights reserved.Objective: This study aims to investigate the effect of Momordica charantia L. (MoC) ethanolic extract on ulcerative colitis (UC) and was explored in vitro and in vivo. Materials and Methods: The rats were divided into control (C), saline-treated colitis (AA), MoC extract-treated colitis (AA+MoC), and sulfasalazine (SS)-treated colitis (AA+SS) groups. Colitis was induced by acetic acid. MoC extract, SS or saline were given to the related groups for 3 days. Interleukine-1β, malondialdehyde, glutathione levels, myeloperoxidase activity, bax/bcl-2 ratio, caspase-9 and caspase-3 levels were measured in colon and macroscopic and histopathologic examinations were done. Total phenolic/flavonoid content and biological activity of MoC were evaluated by in vitro analysis. Results: Compared to the control group, with acetic acid application interleukin-1β levels, myeloperoxidase activity, malondialdehyde levels, bax/bcl-2 ratio, caspase-9 and caspase-3 levels were significantly upregulated, while glutathione levels were significantly decreased in the AA group. In contrast, MoC and SS treatments reduced interleukin-1β, malondialdehyde levels, myeloperoxidase activity, bax/bcl-2 ratio, and caspase-9 and caspase-3 levels. Glutathione levels increased upon MoC or SS treatment. Increased macroscopic and microscopic scoring with AA improved with MoC or SS treatment, but the MoC or SS treated groups had higher score values than the control. Also, in vitro results showed that MoC exhibited 2,2-diphenyl-1- picrylhydrazyl and 2,2\"-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical scavenging activity as well as significant antilipoxygenase activity. In addition, MoC extract showed a potent anti-inflammatory activity compared to standard indomethacin. Conclusion: Our biochemical, in vitro and histopathologic analysis indicate that MoC is likely to prove beneficial in UC therapy.
dc.identifier.citationÖZBEYLİ D., ŞEN A., Aykac A., Terali K., Cilingir-Kaya Ö. T., ŞENKARDEŞ İ., Sener G., "Therapeutic Effects of Momordica charantia L. Ethanolic Extract on Acetic Acid-Induced Ulcerative Colitis in Rats", European Journal of Biology, cilt.80, sa.2, ss.119-128, 2021
dc.identifier.doi10.26650/eurjbiol.2021.1016222
dc.identifier.endpage128
dc.identifier.issn2602-2575
dc.identifier.issue2
dc.identifier.startpage119
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/abb23eb2-ad41-4736-a61f-30f53f3accf4/file
dc.identifier.urihttps://hdl.handle.net/11424/289870
dc.identifier.volume80
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectHistology and Embryology
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectMikrobiyoloji
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectLife Sciences (LIFE)
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMICROBIOLOGY
dc.subjectCELL BIOLOGY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectHücre Biyolojisi
dc.subjectMoleküler Biyoloji
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectCell Biology
dc.subjectMolecular Biology
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectanti-lipoxygenase activity
dc.subjectapoptosis
dc.subjectMomordica charantia L.
dc.subjectoxidative stress
dc.subjectradical scavenging activity
dc.subjectulcerative colitis
dc.subject:Momordica charantia L.
dc.subjectulcerative colitis
dc.subjectapoptosis
dc.subjectoxidative stress
dc.subjectradical scavenging activity
dc.subjectanti-lipoxygenase activity
dc.titleTherapeutic effects of momordica charantia L. Ethanolic extract on acetic acid-induced ulcerative colitis in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idabb23eb2-ad41-4736-a61f-30f53f3accf4
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
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relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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