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Comparison of ketamine/propofol (ketofol) and etomidate/fentanyl (etofen) combinations for procedural sedation and analgesia in the emergency department: An observational study

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dc.contributor.authorSANRI, ERKMAN
dc.contributor.authorsSanri, Erkman; Karacabey, Sinan; Akoglu, Haldun; Kaya, Bora; Guneysel, Ozlem
dc.date.accessioned2022-03-14T10:04:19Z
dc.date.available2022-03-14T10:04:19Z
dc.date.issued2017-09
dc.description.abstractObjectives: The primary aim of this study was to report the vital signs, hemodynamic parameters and pain scores of the patients who have received procedural sedation and analgesia (PSA) with either ketofol (combination of ketamine and propofol) or etofen (combination of etomidate and fentanyl) and compare the proportion of patients with airway or respiratory adverse events (AEs) requiring an intervention and calculate the relative risk of AEs with each combination. Methods: This study is a prospective observational study with survey analysis. All patients received procedural sedation and analgesia (PSA) with either ketofol (combination of ketamine and propofol) or etofen (combination of etomidate and fentanyl) were prospectively observed. Vital and hemodynamic parameters and pain scores of the patients were recorded by automated equipment and visual analog scale (VAS) charts. Results: 112 patients were enrolled, 55 received ketofol and 57 received etofen. All patients with a respiratory AE (n = 27) observed to receive a respiratory intervention. Respiratory AE rate and proportion of patient who required a respiratory intervention were significantly higher with ketofol (p = 0.0029). Overall AE rate, and rates of desaturation, emergence reaction were also significantly higher in ketofol group. Conclusion: Etofen is a promising combination for the PSA of adult patients with lower respiratory AE and intervention rates and with better hemodynamic profile. Copyright (C) 2017 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner.
dc.identifier.doi10.1016/j.tjem.2017.01.003
dc.identifier.issn2452-2473
dc.identifier.pubmed28971155
dc.identifier.urihttps://hdl.handle.net/11424/244000
dc.identifier.wosWOS:000424190300003
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofTURKISH JOURNAL OF EMERGENCY MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProcedural sedation
dc.subjectEmergency department
dc.subjectKetamine
dc.subjectEtomidate
dc.subjectFentanyl
dc.subjectPropofol
dc.subjectDOUBLE-BLIND TRIAL
dc.subjectKETAMINE-PROPOFOL
dc.subjectRANDOMIZED-TRIAL
dc.subjectCLINICAL-TRIAL
dc.subjectCARDIOVERSION
dc.subjectFENTANYL
dc.subjectMIDAZOLAM
dc.subjectADULTS
dc.titleComparison of ketamine/propofol (ketofol) and etomidate/fentanyl (etofen) combinations for procedural sedation and analgesia in the emergency department: An observational study
dc.typearticle
dspace.entity.typePublication
local.avesis.idfd376d4c-e7a5-467e-ab1a-9454e3d13be5
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage94
oaire.citation.issue3
oaire.citation.startPage89
oaire.citation.titleTURKISH JOURNAL OF EMERGENCY MEDICINE
oaire.citation.volume17
relation.isAuthorOfPublication8e7070d2-5627-4e08-afd8-2a8d0e8af68c
relation.isAuthorOfPublication.latestForDiscovery8e7070d2-5627-4e08-afd8-2a8d0e8af68c

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