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Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study

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dc.contributor.authorBOZKURT, SÜHEYLA
dc.contributor.authorsBarisik, Nagehan O.; Bozkurt, Suheyla; Gumus, Mahmut; Kaygusuz, Isik; Karadayi, Nimet; Bas, Emine; Bayik, Mahmut; Tecimer, Tulay
dc.date.accessioned2022-03-14T09:26:30Z
dc.date.available2022-03-14T09:26:30Z
dc.date.issued2010-12
dc.description.abstractBackground: Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a role in tumor progression and carcinogenesis. p53 contributes to apoptosis, DNA renewal and cell cycle. Studies concerning the relationship of cox-2 and p53 expressions and carcinogenesis are available, but the association between cox-2 and p53 in Hodgkin lymphoma (HL) is not exactly known. In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression. Methods: Cox-2 and p53 expressions in Hodgkin-Reed Sternberg cells (HRS) were examined in 54 patients with HL depending on cox-2 expression, stained cases were classified as positive, and unstained cases as negative. Nuclear staining of HRS cells with p53 was evaluated as positive. The classifications of positivity were as follows: negative if<10%; (1+) if 10-25%; (2+) if 25-50%; (3+) if 50-75%, (4+) if >75%. Results: Cox-2 and p53 expressions were found in 49 (80%) and 29 (46%) patients, respectively. There were differences between histological subtypes according to cox-2 expression (p = 0.012). Mixed cellular (MC) and nodular sclerosing (NS) subtypes were seen most of the patients and cox-2 expression was evaluated mostly in the mixed cellular subtype. There were no statistically significant relationships between p53 and the histopathological subtypes; or between p53, cox-2 and the factors including stage, age and survival; or between p53 and cox-2 expression (p > 0.05). Conclusion: Considering the significant relationship between the cox-2 expression and the subtypes of HL, cox-2 expression is higher in MC and NS subtypes. However the difference between these two subtypes was not significant. This submission must be advocated by studies with large series
dc.identifier.doi10.1186/1746-1596-5-19
dc.identifier.eissn1746-1596
dc.identifier.pubmed20346139
dc.identifier.urihttps://hdl.handle.net/11424/243125
dc.identifier.wosWOS:000276609900001
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofDIAGNOSTIC PATHOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCYCLOOXYGENASE-2 GENE-EXPRESSION
dc.subjectREED-STERNBERG CELLS
dc.subjectBCL-2 EXPRESSION
dc.subjectUP-REGULATION
dc.subjectMOUSE MODEL
dc.subjectP53
dc.subjectCANCER
dc.subjectRISK
dc.subjectANGIOGENESIS
dc.subjectINHIBITION
dc.titleExpression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study
dc.typearticle
dspace.entity.typePublication
local.avesis.idaa138643-27ab-4120-a683-6396caa7a8c1
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber19
local.journal.numberofpages7
oaire.citation.titleDIAGNOSTIC PATHOLOGY
oaire.citation.volume5
relation.isAuthorOfPublicationdd039cf9-dfb8-4af0-b879-0b88c3a852fa
relation.isAuthorOfPublication.latestForDiscoverydd039cf9-dfb8-4af0-b879-0b88c3a852fa

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