Publication:
Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease

Simple item page
dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsAgirbasli, M.; Guney, A. I.; Ozturhan, H. S.; Agirbasli, D.; Ulucan, K.; Sevinc, D.; Kirac, D.; Ryckman, K. K.; Williams, S. M.
dc.date.accessioned2022-03-12T17:53:21Z
dc.date.available2022-03-12T17:53:21Z
dc.date.issued2011
dc.description.abstractBackground: Association studies in the Turkish population have investigated the single locus effects of different gene polymorphisms on coronary artery disease (CAD). CAD is a complex polygenic disease that involves complex interactions among multiple genetic and environmental conditions. Design: We evaluated associations of five candidate genetic polymorphisms (methylene tetrahydrofolate reductase C677T, plasminogen activator inhibitor 4G/5G, endothelial nitric oxide synthase (eNOS) 3-27 base pair repeat, insertion, or deletion of a 287 bp Alu repeat sequence polymorhism of angiotensin I converting enzyme, and paraoxonase Gln192Arg PON1 polymorphisms) with the presence and extent of early onset CAD. Methods: DNA was isolated and amplified from 90 consecutive patients with angiographically proven early onset CAD (ages 41 +/- 5 for men, 49 +/- 7 for women) and also from 90 control subjects with no significant coronary obstruction angiographically (ages 42 +/- 5 for men, 48 +/- 6 for women). Multifactor dimensionality reduction (MDR) analysis was performed to identify a model of CAD based on both genetic and conventional risk factors. Results: MDR analysis detected a significant model with four genes (prediction success similar to 61%, p = 0.03). When the total number of the conventional risk factors is analysed with the candidate polymorphisms, a different model is identified that includes three of the four genes from the above model and achieves a similar prediction of CAD as the gene only model. Conclusion: These data indicate that gene-gene and gene-environmental risk interactions form significant models in predicting early onset CAD.
dc.identifier.doi10.1177/1741826711398806
dc.identifier.eissn1741-8275
dc.identifier.issn1741-8267
dc.identifier.pubmed21450592
dc.identifier.urihttps://hdl.handle.net/11424/230458
dc.identifier.wosWOS:000297975200004
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofEUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectACE I/D
dc.subjectcoronary artery disease
dc.subjecteNOS 3-27
dc.subjectGln192Arg PON1
dc.subjectMTHFR C677T
dc.subjectmultifactor dimensionality reduction
dc.subjectPAI-1 4G/5G
dc.subjectEPISTASIS
dc.titleMultifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease
dc.typearticle
dspace.entity.typePublication
local.avesis.iddcd015cb-a311-4c7b-b34c-0781d893e449
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage809
oaire.citation.issue6
oaire.citation.startPage803
oaire.citation.titleEUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
oaire.citation.volume18
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

Files

Collections

Research Outputs