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Ocular findings and blood flow in patients with Takayasu arteritis: a cross-sectional study

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dc.contributor.authorALİBAZ ÖNER, FATMA
dc.contributor.authorsEsen, Fehim; Ergelen, Rabia; Alibaz-Oner, Fatma; Celik, Guelce; Direskeneli, Haner; Kazokoglu, Haluk
dc.date.accessioned2022-03-12T22:38:12Z
dc.date.available2022-03-12T22:38:12Z
dc.date.issued2019
dc.description.abstractBackground/aims Takayasu arteritis (TAK) is a chronic granulomatous vasculitis that can lead to ischaemic ocular complications. We aimed to document ocular complications, ocular blood flow and the association of them with systemic clinical findings in TAK. Material and methods We included 65 patients with TAK (60 female, 5 male, mean age: 41.8 +/- 12.9 years) and 30 healthy subjects (30 female, mean age: 39.0 +/- 7.5 years) in this study. All of the patients had a detailed rheumatological and ophthalmological evaluation. Ocular blood flow in ophthalmic artery (OA) and central retinal artery (CRA) was evaluated with colour Doppler ultrasonography. Results Hypertensive retinopathy was observed in 33.9%, and Takayasu retinopathy was observed in 6.2% of patients. Posterior subcapsular cataracts or a history of cataract surgery was seen in 15.4% of the cases. None of the patients experienced visual loss due to ischaemic or neovascular complications. Patients with TAK had increased resistivity index (RI) in ophthalmic artery (0.75 vs 0.66, p=0.002) and CRA (0.75 vs 0.67, p=0.001). Patients with hypertensive retinopathy had significantly longer disease duration (p=0.016). Ophthalmic artery RI was significantly higher in patients with ipsilateral radial artery pulselessness compared with patients without (0.77 vs 0.68, p=0.031). Conclusion This study reported the lowest prevalence of Takayasu retinopathy and is the only series without permanent visual loss. We documented for the first time that radial artery pulselessness can predict reduction of ipsilateral ocular perfusion. We believe that better management of TAK with current medications reduced ocular complication rates.
dc.identifier.doi10.1136/bjophthalmol-2018-312580
dc.identifier.eissn1468-2079
dc.identifier.issn0007-1161
dc.identifier.pubmed30150277
dc.identifier.urihttps://hdl.handle.net/11424/235539
dc.identifier.wosWOS:000473042100011
dc.language.isoeng
dc.publisherBMJ PUBLISHING GROUP
dc.relation.ispartofBRITISH JOURNAL OF OPHTHALMOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRetina
dc.subjectDiagnostic tests
dc.subjectInvestigation
dc.subjectImaging
dc.subjectImmunology
dc.subjectCOLOR DOPPLER
dc.subjectCLASSIFICATION
dc.subjectCRITERIA
dc.subjectDISEASE
dc.titleOcular findings and blood flow in patients with Takayasu arteritis: a cross-sectional study
dc.typearticle
dspace.entity.typePublication
local.avesis.iddced555d-8688-41bb-b857-cbbfeb051ff6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ1
oaire.citation.endPage932
oaire.citation.issue7
oaire.citation.startPage928
oaire.citation.titleBRITISH JOURNAL OF OPHTHALMOLOGY
oaire.citation.volume103
relation.isAuthorOfPublicatione995a136-8c56-4192-bebe-fe522b567ef1
relation.isAuthorOfPublication.latestForDiscoverye995a136-8c56-4192-bebe-fe522b567ef1

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