Publication:
Production and antioxidant activity of electrospun polylactic acid (pla) nanofibrous mats containing naringenin (nar) for potential wound healing applications

Simple item page
dc.contributor.authorAYAZ SEYHAN, SERAP
dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorBİLĞİÇ ALKAYA, DİLEK
dc.contributor.authorsAYAZ SEYHAN S., Erdag Z., CESUR S., BİLĞİÇ ALKAYA D.
dc.date.accessioned2024-09-12T08:12:21Z
dc.date.available2024-09-12T08:12:21Z
dc.date.issued2024-03-01
dc.description.abstractIn tissue engineering applications, the use of natural compounds without undesired side effects is highly preferred compared to chemical drugs. Flavonoids, polyphenolic compounds distributed widely in plant-based foods, exert diverse biological effects in cultured cells and in vivo. Flavonoids exhibit anti-inflammatory, antioxidant, anti-mutagenic, anti-cancerous, antiproliferative, and proapoptotic activities, enzyme modulating activities with minimal toxicity issues. Naringenin (4′,5,7-trihydroxyflavanone) (NAR) is a flavonoid belonging to the class flavanone, predominantly found in grape fruit, bitter orange, and other citrus fruits. It has very prominent pharmacological actions like antitumor, vasoprotective, antihypertension, antiviral, and dantishockactions. As NAR can scavenge reactive oxygen species, its use in wound dressing studies is increasing. In recent years, many studies have been carried out to produce nanofibrous materials by the electrospinning method. Electrospun nanofibers have very large surface areas, controllable pore sizes, and tunable drug release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including polylactic acid (PLA) have been widely used for the synthesis of nanofibers using the electrospun technique. In this study, nanofibers were obtained by adding NAR at different concentrations into PLA by electrospinning technique. Morphological (Scanning electron microscopy, SEM), molecular interaction (Fourier transform infrared spectroscopy, FT-IR), thermal analysis (Differential scanning calorimetry, DSC), antioxidant activity, and physical analysis were carried out after the production process. Meanwhile, the PLA nanofibers showed the largest swelling value of 220% after immersion in phosphate buffer saline (PBS) solution for 10 days. Overall, this study demonstrates that our PLA/NAR nanofiber mats are attractive candidates for wound dressing material research and application.
dc.identifier.citationAYAZ SEYHAN S., Erdag Z., CESUR S., BİLĞİÇ ALKAYA D., "PRODUCTION AND ANTIOXIDANT ACTIVITY OF ELECTROSPUN POLYLACTIC ACID (PLA) NANOFIBROUS MATS CONTAINING NARINGENIN (NAR) FOR POTENTIAL WOUND HEALING APPLICATIONS", Revue Roumaine de Chimie, cilt.69, sa.3-4, ss.119-127, 2024
dc.identifier.doi10.33224/rrch.2024.69.3-4.02
dc.identifier.endpage127
dc.identifier.issn0035-3930
dc.identifier.issue3-4
dc.identifier.startpage119
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85201723533&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/297695
dc.identifier.volume69
dc.language.isoeng
dc.relation.ispartofRevue Roumaine de Chimie
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectNatural Sciences
dc.subjectTemel Bilimler (Sci)
dc.subjectNatural Sciences (Sci)
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.titleProduction and antioxidant activity of electrospun polylactic acid (pla) nanofibrous mats containing naringenin (nar) for potential wound healing applications
dc.typearticle
dspace.entity.typePublication
local.avesis.idb526ee01-9287-432d-bae0-421ac9ad8724
local.indexed.atSCOPUS
relation.isAuthorOfPublication718255e1-6de8-47ba-8bfd-6a8c55a04479
relation.isAuthorOfPublication155dc947-cf5f-46e3-8ddb-0a1e9751e23f
relation.isAuthorOfPublicationb3f0ae46-715d-4b45-bf08-49abdc4adbf4
relation.isAuthorOfPublication.latestForDiscovery718255e1-6de8-47ba-8bfd-6a8c55a04479

Files

Collections

Research Outputs