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Nicorandil preserves blood-brain barrier and improves memory impairment in hypertensive rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsCevikelli Yakut, Zatiye Ayca; Ertas, Busra; Koyuncuoglu, Turkan; Yegen, Berrak C.; Sener, Goksel
dc.date.accessioned2022-03-14T09:09:57Z
dc.date.available2022-03-14T09:09:57Z
dc.date.issued2019-11-15
dc.description.abstractIn renovascular hypertension (RVH), oxidative stress and inflammation due to high blood pressure and elevated levels of angiotensin 2 are mainly responsible of cerebrovascular complications and impaired cognitive functions. Since the nicorandil has been shown to exert neuroprotective, anti-inflammatory and antioxidant effects, we investigated the effect of nicorandil against vascular dementia and blood brain barrier damage in a rat model of angiotensin-dependent hypertension. Wistar albino rats, were divided as sham-operated control, renovascular hypertension (RVH) and Nicorandil-treated RVH groups. Silver clip was implanted onto the left renal artery. Using the tail-cuff method, blood pressure of rats was measured before the surgery and at the end of the post-surgical 3rd and 12th weeks. Nicorandil (4mg/kg, orally) or vehicle was administered for 9 weeks. Twelve weeks after RVH surgery, a new object recognition test was performed. Following the determination of blood brain barrier integrity, serum samples were taken for the evaluation of proinflammatory cytokines tumor necrosis alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Levels of sodium-potassium adenosine triphosphatase (Na+/K+-ATPase), as a marker of endothelial damage, were evaluated in the hippocampal tissues. RVH resulted in significant increases in TNF-alpha and IL-1 beta levels and decreases in Na+/K+-ATPase levels, along with impairment in blood brain barrier integrity and memory performance. In the nicorandil treatment group, these indices were reversed back to control levels. The present data demonstrated that nicorandil attenuates RVH-induced memory impairment and blood brain barrier damage in rats with RVH.
dc.identifier.doi10.35333/jrp.2019.79
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11424/242676
dc.identifier.wosWOS:000497661000018
dc.language.isoeng
dc.publisherMARMARA UNIV
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenovascular hypertension
dc.subjectangiotensin 2
dc.subjectnicorandil
dc.subjectblood brain barrier
dc.subjectvascular dementia
dc.subjectII-INDUCED HYPERTROPHY
dc.subjectNF-KAPPA-B
dc.subjectRHO-KINASE
dc.subjectPERMEABILITY
dc.subjectINFLAMMATION
dc.subjectSUPEROXIDE
dc.subjectACTIVATION
dc.subjectEXPRESSION
dc.subjectRECEPTOR
dc.subjectSTIMULATION
dc.titleNicorandil preserves blood-brain barrier and improves memory impairment in hypertensive rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ida9109856-d706-49e4-ad7a-bbab14a0c146
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages9
oaire.citation.endPage1148
oaire.citation.issue6
oaire.citation.startPage1140
oaire.citation.titleJOURNAL OF RESEARCH IN PHARMACY
oaire.citation.volume23
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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