Publication:
Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsApikoglu-Rabus, S.; Izzettin, F. V.; Turan, P.; Ercan, F.
dc.date.accessioned2022-03-12T17:47:38Z
dc.date.available2022-03-12T17:47:38Z
dc.date.issued2010
dc.description.abstractBackground. Diabetes is a condition known even in its early stages to impair the normal course of wound healing, thus leading to chronic wounds. The role of insulin in the regulation of energy metabolism, protein synthesis, cell differentiation and growth suggests that this hormone could also play an essential role in regulation of wound healing. Aim. To determine the effects of topical insulin administration on wound healing in rats with or without acute diabetes. Methods. This study was conducted using four groups of male Sprague-Dawley rats: (i) nondiabetic rats receiving topical insulin (n = 7), (ii) nondiabetic rats receiving topical sterile water (n = 7), (iii) diabetic rats receiving topical insulin (n = 7) and (iv) diabetic rats receiving topical sterile water (n = 7). Wound healing was assessed by wound contraction rate, complete epithelialization time and histological results. Results. Topical insulin enhanced wound healing by shortening the time needed for complete epithelialization in both the nondiabetic and acute diabetic groups. The histological observations supported the planimetric results in both groups. Conclusions. This study revealed that topical insulin application to cutaneous wounds accelerates wound healing in rats with or without acute diabetes.
dc.identifier.doi10.1111/j.1365-2230.2009.03419.x
dc.identifier.issn0307-6938
dc.identifier.pubmed19594766
dc.identifier.urihttps://hdl.handle.net/11424/229800
dc.identifier.wosWOS:000273888300015
dc.language.isoeng
dc.publisherWILEY-BLACKWELL PUBLISHING, INC
dc.relation.ispartofCLINICAL AND EXPERIMENTAL DERMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHUMAN EPIDERMAL-KERATINOCYTES
dc.subjectHUMAN-SKIN FIBROBLASTS
dc.subjectGROWTH-FACTOR
dc.subjectSTIMULATION
dc.subjectMIGRATION
dc.subjectBURN
dc.titleEffect of topical insulin on cutaneous wound healing in rats with or without acute diabetes
dc.typearticle
dspace.entity.typePublication
local.avesis.idede59bba-4d64-47b2-82ab-9b31a56c68ec
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage185
oaire.citation.issue2
oaire.citation.startPage180
oaire.citation.titleCLINICAL AND EXPERIMENTAL DERMATOLOGY
oaire.citation.volume35
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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