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18F-FDG PET/CT Findings and Baseline Clinical Parameters in Multiple Myeloma
(CIG MEDIA GROUP, LP, 2017) ATAGÜNDÜZ, IŞIK; Tuglular, Tulin Firatli; Tanrikulu, Funda Pepedil; Toptas, Tayfur; Karadeniz, Asli; Atagunduz, Isik
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3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites
(WILEY-V C H VERLAG GMBH, 2019) YILMAZ, BETÜL; Ulag, Songul; Kalkandelen, Cevriye; Oktar, Faik Nuzhet; Uzun, Muhammet; Sahin, Yesim Muge; Karademir, Betul; Arslan, Sema; Ozbolat, Ibrahim Tarik; Mahirogullari, Mahir; Gunduz, Oguzhan
The present paper aims to overcome the problems related to previous use of autologous grafts using available synthetic grafts. To examine the optimum of the ideal vessel-like constructs parameters are produced at 230 degrees C. At this production temperature, the elastic modulus values of the constructs ranges from 56 MPa to 174 MPa. The maximum cell proliferation is obtained from PCL/7wt.%CS/5wt.%H that is tested by mitochondrial dehydrogenase activity. The structures are visualized with all constructs after cell fixation by making use of the HUVEC cell line.
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3D Printing of Gelatine/Alginate/beta-Tricalcium Phosphate Composite Constructs for Bone Tissue Engineering
(WILEY-V C H VERLAG GMBH, 2019) OKTAR, FAİK NÜZHET; Kalkandelen, Cevriye; Ulag, Songul; Ozbek, Burak; Eroglu, Gunes O.; Ozerkan, Dilsad; Kuruca, Serap E.; Oktar, Faik N.; Sengor, Mustafa; Gunduz, Oguzhan
Bone tissue engineering studies have brought three-dimensional scaffolds into focus that can provide tissue regeneration with designed porosity and strengthened structure. Current research has concentrated on the fabrication of natural and synthetic polymer-based complex structures that closely mimic biological tissues due to their superior biocompatibility and biodegradabilities. Gelatine/Sodium Alginate hydrogels reinforced with different concentrations of beta-Tricalcium Phosphate (TCP) (10, 13, and 15 wt.%) were studied to form 3D bone tissue. Physical, mechanical, chemical, morphological properties and biodegradability of the constructs were investigated. Furthermore, in vitro biological assay with human osteosarcoma cell line (SAOS-2) was performed to determine the biocompatibility of the constructs. It is found that cell viability rates for all constructs were increased and maximum cell viability rate was attained for 20%Gelatine/2%Alginate/10%TCP (wt.). The present work demonstrates that 3D printed Gelatine/Alginate/TCP constructs with porous structures are potential candidates for bone tissue engineering applications.
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7-Oxy-3,4-cyclohexenecoumarin Carrying Novel Zinc(II) and Indium(III) Acetate Phthalocyanines: Synthesis, Characterization, Photophysical and Photochemical Properties
(WILEY-V C H VERLAG GMBH, 2019) YALÇIN, BAHATTİN; Karapinar, Beguemhan; Oezdemir, Muecahit; Salan, Uemit; Durmus, Mahmut; Yalcin, Bahattin; Bulut, Mustafa
In this study, 7-hydroxy-3,4-cyclohexenecoumarin (1), two new phthalonitriles, 7-(2,3-dicyanophenoxy)-3,4-cyclohexene-coumarin (2), 7-(3,4-dicyanophenoxy)-3,4-cyclohexenecoumarin (3), were prepared. The phthalonitrile derivatives 2 and 3 were converted to the respective non-peripheral tetra, peripheral tetra 7-oxy-3,4-cyclohexenecoumarin substituted zinc(II) (4,6) and indium(III)acetate phthalocyanine (5,7) derivatives. All novel purified compounds (2-7) were characterized by elemental analysis, FT-IR, UV-vis, (HNMR)-H-1, 13CNMR, MALDI-TOF mass data. The spectral, photophysical (fluorescence quantum yields and lifetimes), and photochemical (singlet oxygen generation and photodegradation under light irradiation) properties of the synthesized Pcs (4-7) were studied in DMF, and the results were compared to determine the effects of the locations of substituents and the diversity of the central metal atom on these properties. The 7-oxy-3,4-cyclohexenecoumarin bearing phthalocyaninatozinc(II) and indium(III)acetate complexes showed good solubility in organic solvents such as chloroform, dichloromethane, tetrahydrofuran, acetone, DMF and DMSO. The fluorescence quenching behavior were investigated using 1,4-benzoquinone as a quencher. They have an acceptable level of singlet oxygen production, which determines the usability of phthalocyanines in photodynamic therapy applications and demonstrated appropriate photodegradation. The thermal properties of Pcs (4-7) were also investigated.
Open Access
A Better Way to Decrease Knee Swelling in Patients with Knee Osteoarthritis: A Single-Blind Randomised Controlled Trial
(HINDAWI LTD, 2019-05-02) DEMİRBÜKEN, İLKŞAN; Sari, Zubeyir; Aydogdu, Onur; Demirbuken, Ilksan; Yurdalan, S. Ufuk; Polat, M. Gulden
Objective. In this study, we compared the effects of intermittent pneumatic compression along with conventional treatment with cold-pack treatment along with conventional treatment on clinical outcomes in patients with knee osteoarthritis. Methods. Eighty-nine patients with knee osteoarthritis participated in this study. One group received ultrasound, transcutaneous electrical nerve stimulation, electrical stimulation, exercise, and cold packs. The second group received ultrasound, transcutaneous electrical nerve stimulation, electrical stimulation, exercise, and intermittent pneumatic compression. Range of motion, muscle strength, knee swelling, pain intensity, and functional status were measured at baseline and 4th week. Results. We found significant improvements in range of motion, muscle strength, pain intensity, and functional status after the treatment in both groups (p<0.05). When comparing the effects of these two treatment programs, it was observed that the intermittent pneumatic compression treatment group had a better outcome in terms of knee swelling (p=0.028). Conclusions. According to the results, we could report that intermittent pneumatic compression therapy in addition to conventional treatment has significant positive effects on clinical outcomes in patients with knee osteoarthritis. We could also report that intermittent pneumatic compression therapy along with conventional treatment is superior to cold-pack therapy along with conventional treatment in terms of knee swelling in patients with knee osteoarthritis. This trial is registered with NCT03806322.
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A case of primary squamous cell carcinoma of the breast with pathologic complete response after neoadjuvant chemotherapy
(MOSBY-ELSEVIER, 2019) KAYA, HANDAN; Alan, Ozkan; Telli, Tugba Akin; Ercelep, Ozlem; Hasanov, Rahib; Simsek, Eda Tanrikulu; Mutis, Aydan; Ones, Tunc; Kaya, Handan; Yumuk, Perran Fulden
Background: Primary squamous cell carcinoma (SCC) of the breast is a metaplastic carcinoma subtype which includes fibromatosis-like and sarcomatoid features. This is a very aggressive tumor with poor prognosis. Other sites of primary SCC should be ruled out first to classify these tumors as primary SCC of the breast. Here we present a case of locally advanced primary SCC of the breast. Case Report: A 72 years old woman presented with a right axillary lump. Trucut biopsy was performed, it showed squamous cell carcinoma. Estrogen receptor had poor immunoreactivity, negative for both progesteron receptor and HER 2 in immunohistochemistry staining. PETCT imaging were conducted to showing only 6 x 6.5 cm mass in right breast adjacent to axilla, multiple lymphadenomegaly in right axillary. We planned neoadjuvant chemotherapy consisting of weekly paclitaxel followed by epirubicin and cyclophosphamide combination. Postoperative pathology revealed wide necrosis, no viable tumor cell. We started adjuvant anastrozole treatment of 1 mg/day. No evidence of disease was detected after 1 year follow up. Conclusion: Primary squamous cell carcinoma of the breast is a very rare disease with no standard treatment approach. Our case achieved pathologic complete response after neoadjuvant chemotherapy. (C) 2018 Elsevier Inc. All rights reserved.
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A clinical scoring system to predict the development of intraventricular hemorrhage (IVH) in premature infants
(SPRINGER, 2018) Coskun, Yesim; Isik, Semra; Bayram, Tevfik; Urgun, Kamran; Sakarya, Sibel; Akman, Ipek
The aim of this study is to develop a scoring system for the prediction of intraventricular hemorrhage (IVH) in preterm infants in the first 7 days of life. A prospective, clinical study was conducted in Bahcesehir University, Medical Park Goztepe Hospital Neonatal Intensive Care Unit, with the enrollment of 144 preterm infants with gestational age between 24 and 34 weeks. All preterms were followed up for IVH after birth until the 4th week of life. The demographic characteristics and clinical risk factors were noted. Risk factors were analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrence of IVH within the first 7 days of life. The IVH scores were further applied prospectively to 89 preterm infants as validation cohort. Low gestational age (GA), low Apgar score, and having bleeding diathesis were the most important risk factors for IVH. According to these risk factors, a scoring system was developed for IVH ranged from 0 to 5. According to the risk ratios (RR) obtained from the logistic regression model, low GA (ae 28 gestational week), presence of bleeding diathesis within 7 days, and low Apgar score increased the risk of IVH (RR = 3.32 for GA ae 28 gestational week, RR = 6.7 for presence of bleeding diathesis in 7th day, RR = 3 for having low Apgar score). The score was validated successfully in 89 infants. The area under ROC curve was 0.85 for derivation cohort and 0.807 for validation cohort. The predictive ability of the IVH score for derivation and validation cohort was calculated. The negative predictive values of a score less than 4 were 96.4 and 59.1%. Concerning IVH-related sequelae which continue to be a major public health problem, we have developed a feasible predictive model for evaluating the risk for developing IVH for preterm infants in the first 7 days of life.
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A Combined Approach To Crooked Nose Deformity
(SPRINGER, 2016) BİNNETOĞLU, ADEM; Inanli, Selcuk; Binnetoglu, Adem
Crooked nose deformity is a complex anatomical deformity; therefore, repair remains a challenge. Here, we introduce a new technique for crooked nose deformity repair. Twenty-two patients underwent intraoperative evaluations and measurements, followed by surgery using the open rhinoplasty technique. Our method involves three major steps. First is the creation of an asymmetric medial oblique osteotomy using piezoelectric ultrasonic surgery and double lateral osteotomies, wherein the asymmetric bony ascending part of the maxillary bone at the base of the nasal vault is fractured, pushed in, and delivered to the face. Second is septoplasty with L-strut preservation. The L-strut is removed as a 1-cm block caudally from the septal stump of the keystone area. A (or double) fabricated batten cartilage graft is placed on the concave side of the deviation and sutured to cover the septal stump. The L-strut is then replaced and sutured on the batten graft, redirecting the septum toward the midline. Third is an overlapping cruroplasty on the side of the long asymmetrical lower lateral cartilage to equalize both wings and correct tip deviation. Our new technique was effective for the treatment of crooked nose deformity. Our technique of K-stone batten plasty with delivery to the face and overlapping cruroplasty may be an effective surgical method for crooked nose deformity. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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A Comparative Clinical Study of Flap Thickness: Medial Sural Artery Perforator Flap Versus Anterolateral Thigh Flap
(LIPPINCOTT WILLIAMS & WILKINS, 2018) Dogan, Zeynep D. Akdeniz; Ozkan, Melekber Cavus; Tuncer, F. Betul; Sacak, Bulent; Celebiler, Ozhan
Introduction The purpose of this study is to measure flap thicknesses of anterolateral thigh (ALT) and medial sural artery perforator (MSAP) flaps in healthy subjects by Doppler ultrasonography and compare the results in relation to sex and body mass index (BMI). Method The perforators of ALT and MSAP flaps were marked on 30 healthy subjects. The thickness of skin and subcutaneous tissue was measured in millimeters at the site of the perforator using Doppler ultrasonography. Results The mean SD age of the participants was 36.4 +/- 10.5, the mean +/- SD BMI was 25.2 +/- 3.9 (19.4-32.5). The mean +/- SD flap thickness was 11.55 +/- 4.38 mm for ALT and 8.31 +/- 3.6 mm mm for MSAP (P < 0.01). Anterolateral thigh flap was significantly thicker than MSAP in both males (9.02 vs 6.11 mm) and females (14.07 vs 10.52 mm) (P < 0.05). The thickness of both MSAP and ALT flap had a positive correlation with BMI. The relationship was stronger for ALT in males (r = 0.66 for ALT, r = 0.59 for MSAP) and for MSAP in females (r = 0.70 for ALT, r = 0.83 for MSAP). Discussion This study confirms that MSAP flap is thinner than ALT and the results correlate with BMI. Therefore, MSAP flap can be considered a good alternative to ALT, to avoid bulk, in reconstruction of shallower soft tissue defects.
Open Access
A Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty
(GALENOS YAYINCILIK, 2018-01-15) Bereket, Abdullah
Central precocious puberty (CPP) is a diagnosis that pediatric endocrinologists worldwide increasingly make in girls of age 6-8 years and is mostly idiopathic. Part of the reason for increasing referral and diagnosis is the perception among the doctors as well as the patients that treatment of CPP with long-acting gonadotropin-releasing hormon analogues (GnRHa) promote height of the child. Although, the timing and the tempo of puberty does influence statural growth and achieved adult height, the extent of this effect is variable depending on several factors and is modest in most cases. Studies investigating GnRHa treatment in girls with idiopathic CPP demonstrate that treatment is able to restore adult height compromised by precocious puberty. However, reports on untreated girls with precocious puberty demonstrate that some of these girls achieve their target height without treatment as well, thus, blurring the net effect of GnRHa treatment on height in girls with CPP. Clinical studies on treatment of girls with idiopathic CPP on adult stature suffers from the solid evidence-base due mainly to the lack of well-designed randomized controlled studies and our insufficiencies of predicting adult height of a child with narrow precision. This is particularly true for girls in whom age of pubertal onset is close to physiological age of puberty, which are the majority of cases treated with GnRHa nowadays. Heterogeneous nature of pubertal tempo (progressive vs. nonprogressive) leading to different height outcomes also complicates the interpretation of the results in both treated and untreated cases. This review will attemp to summarize and critically appraise available data in the field.
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A database for screening and registering late onset Pompe disease in Turkey
(PERGAMON-ELSEVIER SCIENCE LTD, 2018) KAHRAMAN KOYTAK, PINAR; Gokyigit, Munevver Celik; Ekmekci, Hakan; Durmus, Hacer; Karll, Necdet; Koseoglu, Emel; Aysal, Fikret; Kotan, Dilcan; Ali, Asuman; Koytak, Pinar Kahraman; Karasoy, Hatice; Yaman, Aylin; Sengun, Ihsan Sukru; Sayin, Refah; Tiftikcioglu, Bedile Irem; Soysal, Aysun; Tutkavul, Kemal; Bayrak, Ayse Oytun; Kisabay, Aysin; Elci, Mehmet Ali; Yayla, Vildan; Yilmaz, Ibrahim Arda; Ozdamar, Sevim Erdem; Erdogan, Cagdas; Tasdemir, Nebahat; Oflazer, Piraye Serdaroglu
The aim of this study was to search for the frequency of late onset Pompe disease (LOPD) among patients who had a myopathy with unknown diagnosis registered in the pre-diagnostic part of a novel registry for LOPD within a collaborative study of neurologists working throughout Turkey. Included in the study were 350 patients older than 18 years who have a myopathic syndrome without a proven diagnosis by serum creatine kinase (CK) levels, electrodiagnostic studies, and/or muscle pathology, and/or genetic tests for myopathies other than LOPD. Acid alpha glucosidase (GAA) in dried blood spot was measured in each patient at two different university laboratories. LOPD was confirmed by mutation analysis in patients with decreased GAA levels from either both or one of the laboratories. Pre-diagnostic data, recorded by 45 investigators from 32 centers on 350 patients revealed low GAA levels in a total of 21 patients; from both laboratories in 6 and from either one of the laboratories in 15. Among them, genetic testing proved LOPD in 3 of 6 patients and 1 of 15 patients with decreased GAA levels from both or one of the laboratories respectively. Registry was transferred to Turkish Neurological Association after completion of the study for possible future use and development. Our collaborative study enabled collection of a considerable amount of data on the registry in a short time. GAA levels by dried blood spot even from two different laboratories in the same patient may not prove LOPD. LOPD seemed to be rarer in Turkey than in Europe. (C) 2017 Elsevier B.V. All rights reserved.
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A detailed survey for determination of the grafted semifluorinated acrylic compound effect on thermal, microstructural, free volume, mechanical and morphological features of HDPE
(ELSEVIER SCIENCE SA, 2020) TAV, CUMALİ; Soykan, Ugur; Sen, Behiye Ozturk; Cetin, Sedat; Yahsi, Ugur; Tav, Cumali
This study mainly aims to investigate the role of grafted semifluorinated acrylic compound in the crucial characteristic properties of high density polyethylene (HDPE). Graft copolymerization of the semifluorinated acrylic compound, 3,3,4,4,5,5,6,6,7,7,8,8,8-dodecafluoro-5-methyloctyl-4-(acryloyloxy) benzoate (ABCF13) onto HDPE within the different content levels of ABCF13 (5, 10, 15, 20, 30 and 40 %) was performed by bulk-melt polymerization method. The changes in the thermal, microstructural and free volume characteristics of graft coproducts with extent of grafting were investigated in detail by means of DSC, powder X-ray diffraction and PALS techniques, respectively. The experimental findings showed that the melting temperature of crystalline domains and crystallinity ofHDPE reached the maxima at the 15 % and 40 % ABCF13 contents, respectively. The grafting of ABCF13 onto HDPE also gave rise to significant expansion and contraction in lateral dimensions of orthorhombic unit cell parameters in the crystalline domains of HDPE. Moreover, PALS analyses depicted that the size of the free volumes increased almost linearly with the grafting percentage. As for mechanical behaviours of the graft products, remarkable improvements were achieved in especially tensile strength (from 18.75 MPa to 43.75 MPa) and impact strength (from 19.30 Mpa to 38.72 MPa). The morphological properties of the fractured surfaces obtained from tensile and impact tests of products were also examined by SEM analysis. The samples possessed completely homogeneous structure without any phase separation. A gradual transition from ductile behaviour to brittle nature was observed as the grafting level increased in the products.
Open Access
A Europe-wide assessment of antibiotic resistance rates in Bacteroides and Parabacteroides isolates from intestinal microbiota of healthy subjects
(ELSEVIER SCI LTD, 2020-04) ÜLGER, NURVER; Soki, Jozsef; Wybo, Ingrid; Hajdu, Edit; Toprak, Nurver Ulger; Jeverica, Samo; Stingu, Catalina-Suzana; Tierney, Daniel; Perry, John David; Matuz, Maria; Urban, Edit; Nagy, Elisabeth
Here, we sought to assess the levels of antibiotic resistance among intestinal Bacteroides and Parabacteroides strains collected between 2014 and 2016 in Europe and also attempted to compare resistance levels between clinical and commensal isolates. Bacteroides and Parabacteroides isolates were recovered from faecal samples via the novel Bacteroides Chromogenic Agar (BCA) method. Antibiotic susceptibilities were determined by agar dilution for ten antibiotics. The values obtained were then statistically evaluated. Altogether 202 Bacteroides/Parabacteroides isolates (of which 24, 11.9%, were B. fragilis) were isolated from the faecal specimens of individuals taken from five European countries. The percentage values of isolates resistant to ampicillin, amoxicillin/clavulanate, cefoxitin, imipenem, clindamycin, moxifloxacin, metronidazole, tetracycline, tigecycline and chloramphenicol were 96.6, 4.5, 14.9, 2.0, 47.3, 11.4, 0, 66.2, 1.5 and 0%, respectively. These values are close to those reported in the previous European clinical Bacteroides antibiotic susceptibility survey except for amoxicillin/clavulanate and clindamycin, where the former was lower and the latter was higher in normal microbiota isolates. To account for these latter findings and to assess temporal effects we compared the data specific for Hungary for the same period (2014-2016), and we found differences in the resistance rates for cefoxitin, moxifloxacin and tetracycline. (C) 2020 Elsevier Ltd. All rights reserved.
Open Access
A first-principles study of magnetic properties of Zn0.94Mg0.01Mn0.05O
(IOP PUBLISHING LTD, 2020-01-10) Duru, I. P.; Ozugurlu, E.; Arda, L.
The structural and magnetic properties of Mg/Mn-doped ZnO were investigated by the first-principles study and Monte Carlo methods (MCs). Applying magnetic force theorem (MFT) and using Kohn-Sham orbitals in the GGA-PBE scheme, the exchange coupling parameters (J) were calculated to figure out the magnetic interactions between atomic sites. Mn-Mg volume clustered (C1) ferromagnetic (FM) state was preferred; herewith, the calculated magnetic moment of Mn was 4.19 mu(B) and Mg has the highest moment value when clustered with Mn ions. Nearest Mn ions interacted antiferromagnetic (AFM) despite the increasing distance lead them to be in FM. However, AFM/FM was originated from the p-d hybridization, superexchange interaction and direct exchange between distant Mn ions. In addition, the Curie temperature (T-c) was calculated as 311K using averaged magnetization and magnetic susceptibility via MC.
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A fuzzy failure mode and effects approach to analyse concentrated inspection campaigns on board ships
(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2016) AKGÜN, İLKER; Akyuz, Emre; Akgun, Ilker; Celik, Metin
Maritime actions against substandard operations of ships are a great deal of memorandum of understanding (MoUs) under regional basis agreements among port state control (PSC) organisations. Herein, concentrated inspection campaigns (CIC), performed by the different members of MoUs in certain periods, are a monitoring strategy to effectively control the core operational matters encountered in fire-safety systems, propulsion and auxiliary machinery system, lifesaving appliances, working conditions on board ships, etc. This paper proposes a quantified maritime safety analysis based on fuzzy failure mode and effects analysis (FMEA) to evaluate CIC database of MoUs in order to achieve advance creative solutions. Demonstration studies are performed on the special database on fire-safety system deficiencies. Since the fuzzy FMEA outcomes point out the risk prioritisation numbers and relevant control options, the paper attempts to transform CIC feedback into useful information in terms of enhancing the ship PSC inspection concept (e-PSC inspection). The paper theoretically contributes to safety analysis methods in literature while demonstration of e-PSC inspections offers an insight into maritime industry in safety improvement.
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A Genetic Algorithm Based Multi-Objective Optimization of Squealer Tip Geometry in Axial Flow Turbines: A Constant Tip Gap Approach
(ASME, 2020) ALPMAN, EMRE; Maral, H.; Senel, C. B.; Deveci, K.; Alpman, E.; Kavurmacioglu, L.; Camci, Cengiz
Tip clearance is a crucial aspect of turbomachines in terms of aerodynamic and thermal performance. A gap between the blade tip surface and the stationary casing must be maintained to allow the relative motion of the blade. The leakage flow through the tip gap measurably reduces turbine performance and causes high thermal loads near the blade tip region. Several studies focused on the tip leakage flow to clarify the flow-physics in the past. The squealer design is one of the most common designs to reduce the adverse effects of tip leakage flow. In this paper, a genetic-algorithm-based optimization approach was applied to the conventional squealer tip design to enhance aerothermal performance. A multi-objective optimization method integrated with a meta-model was utilized to determine the optimum squealer geometry. Squealer height and width represent the design parameters which are aimed to be optimized. The objective functions for the genetic-algorithm-based optimization are the total pressure loss coefficient and Nusselt number calculated over the blade tip surface. The initial database is then enlarged iteratively using a coarse-to-fine approach to improve the prediction capability of the meta-models used. The procedure ends once the prediction errors are smaller than a prescribed level. This study indicates that squealer height and width have complex effects on the aerothermal performance, and optimization study allows to determine the optimum squealer dimensions.
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A global knowledge, attitudes and practices survey on anatomical endoscopic enucleation of prostate for benign prostatic hyperplasia among urologists
(WILEY, 2020) TANIDIR, YILÖREN; Gudaru, Kalyan; Gonzalez Padilla, Daniel A.; Castellani, Daniele; Tortolero Blanco, Leonardo; Tanidir, Yiloren; Ka Lun, Lo; Wroclawski, Marcelo Langer; Maheshwari, Pankaj N.; De Figueiredo, Felipe Carvalho A.; Yuen-Chun Teoh, Jeremy
There is an increasing use of the procedure, anatomical endoscopic enucleation of the prostate, as an alternative to conventional transurethral resection of prostate for surgical treatment of benign prostatic hyperplasia. However, barriers to adoption of this procedure remain and no prior studies explored this important aspect till date. The aim of this study is to identify the predictors and barriers of surgeon-related practices in this area. The study findings may also provide valuable insight into current practice trends worldwide. To achieve the objectives, we conducted an online, cross-sectional, questionnaire-based study between 1st September 2019 and 5th October 2019 to investigate the knowledge, attitudes and practices among urologists worldwide. Our findings showed that the main barriers for adoption of the procedure were lack of mentorship, a steep learning curve, and unavailability of morcellator, bipolar or laser energy sources. Fear of urinary incontinence, bleeding and bladder injury were not major hindrance to adoption of this technique. The results also demonstrated that there will be continued increase in utility of the procedure in the future.
Open Access
A multicenter survey of antimicrobial susceptibility of Prevotella species as determined by Etest methodology
(ELSEVIER SCI LTD, 2018-08) ÜLGER, NURVER; Toprak, Nurver Ulger; Veloo, Alida C. M.; Urban, Edit; Wybo, Ingrid; Justesen, Ulrik S.; Jean-Pierre, Helene; Morris, Trefor; Akgul, Oncu; Kulekci, Guven; Soyletir, Guner; Nagy, Elisabeth
Knowledge about the antimicrobial susceptibility patterns of different Prevotella species is limited. The aim of this study was to determine the current antimicrobial susceptibility of clinical isolates of Prevotella species from different parts of Europe, Kuwait and Turkey. Activity of 12 antimicrobials against 508 Prevotella isolates, representing 19 species, were tested according to Etest methodology. EUCAST, CLSI and FDA guidelines were used for susceptibility interpretations. All Prevotella species were susceptible to piperacillin/tazobactam, imipenem, meropenem, tigecycline and metronidazole. Ampicillin/sulbactam and cefoxitin also showed good activity. Ampicillin, clindamycin, tetracycline and moxifloxacin were less active; 51.2%, 33.7%, 36.8% and 18.3% of isolates were non-susceptible, respectively. A total of 49 (9.6%) isolates were resistant to three or more antimicrobials. Prevotella bivia was the most prevalent species (n = 118) and accounted for most of the multidrug-resistant isolates. In conclusion, the level of nonsusceptibility to antimicrobials, which may be used for treatment of infections involving Prevotella species, are a cause of concern. This data emphasizes the need for species level identification of clinical Prevotella isolates and periodic monitoring of their susceptibility to guide empirical treatment. (C) 2018 Published by Elsevier Ltd.
Open Access
A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19
(LIPPINCOTT WILLIAMS & WILKINS, 2020-10) Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Akin, Ilke Mungan; Can, Emrah; Demir, Nihat; Arayici, Sema; Baser, Demet Orhan; Caner, Ibrahim; Memisoglu, Asli; Uygun, Saime Sundus; Akar, Selahattin; Akin, Mustafa Ali; Ataoglu, Emel; Bezirganoglu, Handan; Bilgin, Leyla; Bozdag, Senol; Comert, Serdar; Gurpinar, Resat; Imamoglu, Ebru Yalin; Imdadoglu, Timucin; Narter, Fatma; Ozdemir, Ramazan; Toptan, Handan Hakyemez; Yalinbas, Emine Esin; Yaman, Akan; Erdeve, Omer; Koc, Esin
Background: Coronavirus disease 2019 (COVID-19) primarily affects adults and spares children, whereas very little is known about neonates. We tried to define the clinical characteristics, risk factors, laboratory, and imagining results of neonates with community-acquired COVID-19. Methods: This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. Full-term and premature neonates diagnosed with COVID-19 were included in the study, whether hospitalized or followed up as ambulatory patients. Neonates without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) via reverse transcriptase-polymerase chain reaction testing or whose mothers had been diagnosed with COVID-19 during pregnancy were excluded. Results: Thirty-seven symptomatic neonates were included. The most frequent findings were fever, hypoxemia, and cough (49%, 41%, 27%, respectively). Oxygen administration (41%) and noninvasive ventilation (16%) were frequently required; however, mechanical ventilation (3%) was rarely needed. Median hospitalization was 11 days (1-35 days). One patient with Down syndrome and congenital cardiovascular disorders died in the study period. C-reactive protein (CRP) and prothrombin time (PT) levels were found to be higher in patients who needed supplemental oxygen (0.9 [0.1-8.6] vs. 5.8 [0.3-69.2]p= 0.002, 11.9 [10.1-17.2] vs. 15.2 [11.7-18.0]p= 0.01, respectively) or who were severe/critical (1.0 [0.01-8.6] vs. 4.5 [0.1-69.2]p= 0.01, 11.7 [10.1-13.9] vs. 15.0 [11.7-18.0]p= 0.001, respectively). Conclusions: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease.
Metadata only
A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine
(BENTHAM SCIENCE PUBL LTD, 2018) TURANLI, BESTE; Turanli, Beste; Karagoz, Kubra; Gulfidan, Gizem; Sinha, Raghu; Mardinoglu, Adil; Arga, Kazim Yalcin
A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in omic sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented for a holistic interpretation of the entire system. Ultimately, network-based methods will effectively facilitate the development and improvement of precision medicine by directing therapies based on the underlying biology of a given patient's disease. The goal of precision medicine is to identify novel therapeutic strategies that can be optimized for each disease type or each patient based on the underlying genetic, environmental, and lifestyle factors. Pharmaco-omics analyses based on an integration of pharmacology and various omics data types can be employed to develop effective treatment strategies using particular drugs and doses that are tailored to each individual. In the current review, we first present the core elements of network-based systems biology in the context of pharmaco-omics followed by integration of multi-omics data using various biological networks. Next, we provide an opening into precise medicine and drug targeting based on network approaches. Lastly, we review the current significant efforts as well as the accomplishments and limitations in precise drug targeting with the utility of network-based guided drug discovery methods for effective treatment of breast cancer.

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