Person: ÇİÇEK DENİZ, NESLİHAN
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ÇİÇEK DENİZ
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NESLİHAN
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Publication Metadata only Clinical predictors of steroid resistance in childhood nephrotic syndrome(2023-12-24) ÇİÇEK DENİZ, NESLİHAN; Cicek N., Yıldız N., Guven S., Kaya M., Gokce I., Alpay H.We aimed to evaluate the clinical parameters, histopathological findings of nephrotic syndrome (NS) patients, and independent factors predicting steroid resistance in a single tertiary center. One hundred and sixty-two children (57 girls and 105 boys) with NS who were followed between 1998 and 2018 were analyzed in this retrospective cohort. The median (interquartile range; range) age and follow-up time were 4.9 (5.7; 0.1-16.8) and 5.5 (5.4; 0.1-20.3) years. A total of 82.7% of the patients were steroid-sensitive nephrotic syndrome (SSNS) and 17.3% were steroid-resistant nephrotic syndrome (SRNS). The median age at first presentation was lower in the SSNS group (P = .002). The most common histopathological findings were focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Hypertension and macroscopic and microscopic hematuria were higher in the SRNS group (P < .001). The age and microscopic hematuria were independent risk factors for steroid resistance (P = .019 and P = .002, respectively). Complement 3 (C3) was evaluated in 148 patients and found low in 7 patients who were subsequently diagnosed as membranoproliferative glomerulonephritis. There is still no better clinical predictor for steroid response than late age of onset and microscopic hematuria. Hypertension may also give a hint for potential steroid resistance.Publication Metadata only Çok nadir görülen bir olgu: üç üreter ve VUR(2018-05-03) ÇİÇEK DENİZ, NESLİHAN; YILDIZ, NURDAN; ALPAY, HARİKA; Tugtepe H., canmemiş a., ÇİÇEK N., YILDIZ N., ALPAY H., dağlı t.Publication Metadata only Klasik ve antenatal bartter sendromlu çocuklarda fenotipik ve genotipik özellikler(2021-09-04) GÖKCE, İBRAHİM; DEMİRCİ BODUR, ECE; ÇİÇEK DENİZ, NESLİHAN; ATA, PINAR; YILDIZ, NURDAN; GÜVEN S., GÖKCE İ., ALAVANDA C., DEMİRCİ BODUR E., ÇİÇEK N., SAK M., PUL S., TÜRKKAN Ö. N., ATA P., YILDIZ N., et al.Publication Metadata only Dizüri(İstanbul Tıp Kitapevleri, 2021-01-01) ÇİÇEK DENİZ, NESLİHAN; ALPAY, HARİKA; ÇİÇEK N., ALPAY H.Publication Metadata only Anxiety, depression and coping of children with chronic kidney disease and their caregivers during the COVID-19 pandemic(2021-09-16) YILDIZ, NURDAN; ÇİÇEK DENİZ, NESLİHAN; DEMİRCİ BODUR, ECE; ALPAY, HARİKA; TÜRKKAN Ö. N., YILDIZ N., ÇİÇEK N., DEMİRCİ BODUR E., GÜVEN S., SAK M., PUL S., ALPAY H.Introduction: In this study, we aimed to evaluate our patients with chronic kidney disease(CKD) or kidney transplant recipients(KTx) and their parent’s/caregiver’s anxiety and depression levels and abilities of coping with difficulties during the COVID-19 pandemic. Material and methods: This cross-sectional study was conducted on 80 children with predialysis CKD, children on dialysis and KTx, 30 healthy children between 7-18 years of age and their care providers. Children were surveyed by the Strengths and Difficulties Questionnaire(SOQ-T), Screen for Child Anxiety Related Disorders(SCARED), childhood depression inventory and parents or caregivers by Coping Attitudes Assessment Scale(COPE), Beck Depression Inventory and Beck Anxiety Inventory.All questionnaires were done face-to-face or by phone and scored in accordance with the scales. Results: Signs of anxiety (SCARED scores) was present in 26(32.5%) patients and 4(13.3%) controls, and significantly higher in children with CKD and KTx recipients (p=0.03). Sixty-nine children and all controls have a depression scale of >19 and control group showed significantly higher depression scores than the patients (mean±SD,51.6±2.8 vs. 47.5±11.1; respectively, p=0.009). Thirteen (16.3%) patient and 2(6.7%) controls have high SDQDysregulation Profile(SDQ-DP) scores. SDQ-DP scores of the patients were significantly higher than the controls (9.6±5.3 vs. 7.2 ±5.8, respectively; p=0.000). There was no significant difference of mothers in coping with difficulties, anxiety and depression scores between the groups(p>0.05). Higher degree of anxiety of the patients was significantly associated with higher anxiety and depression symptoms of the mothers in the patients group (r=0.5, p=0.000 and r=0.435,p=0.001;respectively ),whereas there was no relationship between the SDQ-DP of the patients and Beck anxiety and depression scores of the mothers Conclusions: The COVID-19 outbreak causes increased anxiety in children with CKD and KTx and increased depression in healthy children. We may speculate that higher depression scores in healthy children may be due to sudden lifestyle restrictions during the pandemic compared to CKD patients who already have certain restrictions. The association of the increased anxiety of the patients with the depression and anxiety of the mothers has shown the necessity of more attention from mental health practitioners. Identifying affected children as early as possible and providing professional psychological and behavioral interventions will ensure a better mental health for children with chronic kidney diseases and their caregivers during the pandemic.Publication Metadata only Periton diyaliz hastalarının erişkin nefrolojisi bölümüne devredilmesi(2021-01-01) ÇİÇEK DENİZ, NESLİHAN; ALPAY, HARİKA; ÇİÇEK N., ALPAY H.Diyaliz tedavisi ve böbrek naklindeki gelişmeler sonucunda, son dönem böbrek yetmezliğinde olan daha fazla sayıda çocuk hasta erişkin döneme ulaşmaktadır. Böbrek nakli kısa dönemde mümkün değilse, periton diyaliz tedavisi genellikle hem sağlık personelinin hem de ailenin tercihi olmaktadır. Genç hastalar için aile merkezli ve koruyucu yaklaşıma sahip çocuk kliniklerinden kendi sorumluluğunu almasını bekleyen erişkin kliniklerine devir (transition) zor olabilir. Bu geçişin hastanın yaşına ve gelişimine uygun olması, tıbbi ve psikolojik gereksinimlerini karşılaması gerekir. Geçiş işlemi hasta dışında ailesini, çocuk doktorunu, erişkin doktorunu, hemşireleri ve sosyal bakım uzmanlarını da içermelidir. Bu işlem özel geçiş polikliniklerinde yapılmalı, bu polikliniklerde hasta izleyen çocuk nefroloji doktoru tarafından tıbbi özeti ile erişkin nefroloji doktoruna sunulmalı ve genç hasta erişkin doktoru ile tanıştırılmalıdır. Periton diyaliz tedavisi almakta olan adolesan hastalar için yapılan uygun ve başarılı devir işlemi, genç hastanın gelecekteki tedavisini ve hastalığının prognozunu olumlu etkileyecektir.Publication Metadata only C3 glomerulopatide klinik seyir ve prognoz(2018-02-15) ÇİÇEK DENİZ, NESLİHAN; GÖKCE, İBRAHİM; YILDIZ, NURDAN; ALPAY, HARİKA; ÇİÇEK N., GÖKCE İ., YILDIZ N., SAK M., ALPAY H.Publication Metadata only Clinic spectrum of cubulin mutations(2022-11-13) ÇİÇEK DENİZ, NESLİHAN; ALPAY, HARİKA; GÖKCE, İBRAHİM; Çiçek N., Alpay H., Güven S., Türkkan Ö. N., Pul S., Demirci E., Alavanda C., Yıldız N., Ata P., Gökce İ.