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BUĞDAYCI, ONUR

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    PublicationOpen Access
    Clinicopathologic and radiologic characteristics of pleomorphic lobular breast cancer
    (2021-01-01) KAYA, HANDAN; BUĞDAYCI, ONUR; UĞURLU, MUSTAFA ÜMİT; ARIKAN R., AKIN TELLİ T., ALAN Ö., DEMİRCAN N. C. , BAŞOĞLU T., ERCELEP Ö., KAYA H., BUĞDAYCI O., UĞURLU M. Ü. , ÖZGEN Z., et al.
    Objectives: The objective of the study was to evaluate clinicopathologic and radiologic features of patients with pleomorphic lobular breast cancer (pleomorphic lobular carcinoma [PLC]). Methods: We retrospectively evaluated the clinicopathologic and radiologic features of 25 PLC patients treated in our division from 2012 to 2018. Results: Median age was 50 (range, 42–55) and 48% were postmenopausal. The presence of spiculated mass was 92%. Median tumor size was 21.9 mm (SD±12.7 mm) and axillary lymph node positivity was 44%. Frequency of microcalcification was 12% and frequency of occult breast cancer was 8%. About 72% of patients had Stage 2 or 3 disease. De novo metastatic disease was 8% and another 8% developed metastasis during follow-up. ER, PR, and Her2/neu were positive in 76%, 44%, and 8%, respectively, and 16% of patients were triple negative. All tumors were Grade III. Median Ki-67 was 22% (range 3–90%). Frequency of lymphovascular invasion was 52%. Patients were followed median of 34.5 months (95% CI, 22.2–46.8), since during this period, two patients recurred and five died, median disease-free survival and overall survival could not be reached. Conclusion: Our data suggest that patients with PLC present with poor prognostic features such as large tumor size, axillary lymph node positivity, and high lymphovascular invasion and tumor grade and Ki-67