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ALPAY, HARİKA

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HARİKA

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Author: DEMİRCİ BODUR, ECE × Subject: Klinik Tıp (MED) ×

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Now showing 1 - 7 of 7
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    Could neutrophıl-lymphocyte ratıo be used as a prognostıc factor ın hemolytıc uremıc syndrome?
    (2022-11-01) YILDIZ, NURDAN; BİLGÜN, CEREN; DEMİRCİ BODUR, ECE; GÖKCE, İBRAHİM; ALPAY, HARİKA; YILDIZ N., BİLGÜN C., Guven S., DEMİRCİ BODUR E., Cicek N., Pul S., Turkkan O. N. , GÖKCE İ., ALPAY H.
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    Clinical spectrum of cubulin mutations
    (2022-11-01) ALPAY, HARİKA; DEMİRCİ BODUR, ECE; ALAVANDA, CEREN; YILDIZ, NURDAN; ATA, PINAR; GÖKCE, İBRAHİM; Cicek N., ALPAY H., Guven S., Turkkan O. N. , Polat S., DEMİRCİ BODUR E., ALAVANDA C., YILDIZ N., ATA P., GÖKCE İ.
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    PublicationOpen Access
    Catastrophic antiphospholipid syndrome accompanied by complement regulatory gene mutation
    (2023-03-01) GÖKCE, İBRAHİM; DEMİRCİ BODUR, ECE; ÇİÇEK DENİZ, NESLİHAN; SAK, MEHTAP; FİLİNTE, DENİZ; ALPAY, HARİKA; Pul S., GÖKCE İ., DEMİRCİ BODUR E., Guven S., ÇİÇEK N., SAK M., Turkkan O. N., FİLİNTE D., Pehlivanoglu C., Sozeri B., et al.
    Background. Antiphospholipid syndrome (APS), particularly the catastrophic antiphospholipid syndrome (CAPS), is one of the rare causes of thrombotic microangiopathy (TMA). CAPS is the most severe form of APS, especially when accompanied by complement dysregulation, causes progressive microvascular thrombosis and failure in multiple organs. In this report, a case of CAPS with TMA accompanied by a genetic defect in the complement system is presented.Case. A 13-year-old girl was admitted to the hospital with oliguric acute kidney injury, nephrotic range proteinuria, Coombs positive hemolysis, refractory thrombocytopenia, a low serum complement C3 level and anti-nuclear antibody (ANA) positivity. The kidney biopsy was consistent with TMA. She was first diagnosed with primary APS with clinical and pathological findings and double antibody positivity. As initial treatments, plasmapheresis (PE) was performed and eculizumab was also administered following pulse -steroid and intravenous immunoglobulin treatments. Her renal functions recovered and she was followed up with mycophenolate mofetil, hydroxychloroquine, low dose prednisolone and low molecular weight heparin treatments. The patient presented with severe chest pain, vomiting and acute deterioration of renal functions a few months after the diagnosis of TMA. A CAPS attack was considered due to radiological findings consistent with multiple organ thrombosis and intravenous cyclophosphamide (CYC) was given subsequent to PE. After pulse CYC and PE treatments, her renal functions recovered, she is still being followed for stage-3 chronic kidney disease. Complement factor H-related protein I gene deletion was detected in the genetic study.Conclusions. The clinical course of complement mediated CAPS tends to be worse. Complement system dysregulation should be investigated in all CAPS patients, and eculizumab treatment should be kept in mind if detected.
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    Usıng cortıcosteroıds ın the treatment of acute tubular necrosıs: effectıve or not?
    (2022-11-01) GÖKCE, İBRAHİM; DEMİRCİ BODUR, ECE; YILDIZ, NURDAN; ALPAY, HARİKA; GÖKCE İ., Pul S., DEMİRCİ BODUR E., Turkkan O. N. , Guven S., Cicek N., YILDIZ N., ALPAY H.
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    A late onset uveıtıs after tubuloıntertıtıal nephrıtıs and uveıt (tınu) syndrome
    (2022-11-01) DEMİRCİ BODUR, ECE; GÖKCE, İBRAHİM; BAYRAKTAR, SEZİN; YILDIZ, NURDAN; ALPAY, HARİKA; DEMİRCİ BODUR E., GÖKCE İ., BAYRAKTAR S., Pul S., Turkkan O. N. , Guven S., Cicek N., YILDIZ N., ALPAY H.
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    PublicationOpen Access
    Recurrent acute kıdney ınjury due to thrombosıs of the vena cava ınferıor
    (2022-11-01) DEMİRCİ BODUR, ECE; YILDIZ, NURDAN; TRUE, ÖMER; ALPAY, HARİKA; GÖKCE, İBRAHİM; Turkkan O. N. , GÖKCE İ., Barlas B., Pul S., DEMİRCİ BODUR E., Guven S., Cicek N., YILDIZ N., DOĞRU Ö., ALPAY H.
    Rationale: Acute kidney injury (AKI) is a frequent complication after liver transplantation. In some patients, prompt intervention targeted at a specific etiology is of paramount importance.Presenting concerns of the patients: A 25 years old man with advanced liver cirrhosis caused by sclerosing cholangitis and autoimmune hepatitis underwent orthotopic liver transplantation. One month after surgery, severe AKI developed in conjunction with recurrent ascites and lower extremity edema. Notable clinical findings included a persistently low urinary sodium excretion, a bland urinary sediment, and an abnormally monophasic hepatic vein waveform on Doppler ultrasound.Diagnoses: Inferior vena cava stenosis.Interventions: Angioplasty with stent installation.Outcomes: Rapid improvement of renal function after stent installation.Lessons learned: The following case illustrates the importance of integrating clinical cues, ultrasound features, and laboratory findings. The combination of AKI associated with lower extremity edema, abnormal monophasic hepatic vein flow on Doppler ultrasound, and a low urinary sodium excretion after liver transplantation should evoke the possibility of inferior vena cava stenosis as the etiologic factor.
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    Genetıc tests ın non-neurogenıc neurogenıc bladder: two sıblıngs wıth ochoa syndrome
    (2022-11-01) GÖKCE, İBRAHİM; ALAVANDA, CEREN; ŞEKERCİ, ÇAĞRI AKIN; DEMİRCİ BODUR, ECE; YILDIZ, NURDAN; YÜCEL, SELÇUK; ATA, PINAR; ALPAY, HARİKA; Pul S., GÖKCE İ., ALAVANDA C., ŞEKERCİ Ç. A. , DEMİRCİ BODUR E., Turkkan O. N. , Guven S., Cicek N., YILDIZ N., YÜCEL S., et al.