Person: ALPAY, HARİKA
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ALPAY
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HARİKA
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Publication Metadata only Could neutrophıl-lymphocyte ratıo be used as a prognostıc factor ın hemolytıc uremıc syndrome?(2022-11-01) YILDIZ, NURDAN; BİLGÜN, CEREN; DEMİRCİ BODUR, ECE; GÖKCE, İBRAHİM; ALPAY, HARİKA; YILDIZ N., BİLGÜN C., Guven S., DEMİRCİ BODUR E., Cicek N., Pul S., Turkkan O. N. , GÖKCE İ., ALPAY H.Publication Metadata only Clinical spectrum of cubulin mutations(2022-11-01) ALPAY, HARİKA; DEMİRCİ BODUR, ECE; ALAVANDA, CEREN; YILDIZ, NURDAN; ATA, PINAR; GÖKCE, İBRAHİM; Cicek N., ALPAY H., Guven S., Turkkan O. N. , Polat S., DEMİRCİ BODUR E., ALAVANDA C., YILDIZ N., ATA P., GÖKCE İ.Publication Open Access Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study(2023-01-01) ALPAY, HARİKA; YILDIZ, NURDAN; AKSU B., Afonso A. C., Akil I., ALPAY H., Atmis B., Aydog O., Bayazıt A. K., Bayram M. T., Bilge I., Bulut I. K., et al.Background: One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study. Methods: A total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI. Results: Urine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001). Conclusions: Urine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI. Graphical abstract: [Figure not available: see fulltext.]Publication Metadata only Urinary hsp70 improves diagnostic accuracy for urinary tract infection in children: utilise study(2022-11-01) ALPAY, HARİKA; YILDIZ, NURDAN; YILMAZ A., Afonso A. C. , Akil I., AKSU B., ALPAY H., Atmis B., Aydog O., KARABAY BAYAZIT A., Bayram M. T. , Bilge I., et al.Publication Metadata only Usıng cortıcosteroıds ın the treatment of acute tubular necrosıs: effectıve or not?(2022-11-01) GÖKCE, İBRAHİM; DEMİRCİ BODUR, ECE; YILDIZ, NURDAN; ALPAY, HARİKA; GÖKCE İ., Pul S., DEMİRCİ BODUR E., Turkkan O. N. , Guven S., Cicek N., YILDIZ N., ALPAY H.Publication Open Access Assessment of the oral health status of children with chronic kidney disease(2023-01-01) KAYA, REMZİYE; YILDIZ, NURDAN; KARGÜL, BETÜL; ALPAY, HARİKA; SEZER B., KAYA R., Dokumacigil N. K., SIDDIKOĞLU D., Guven S., YILDIZ N., ALPAY H., KARGÜL B.Background There are various oral symptoms related to the disease and its management in individuals with chronic kidney disease (CKD). The aim of the study was to investigate the oral health status of children with diferent stages of CKD, kidney transplant recipients (KTR), and healthy children. Methods A total of seventy-one children diagnosed with CKD and ffty-two healthy children were included in the study. Each patient was examined for dental caries by the decayed-missing-flled-teeth (DMFT/dmft) index and the International Caries Detection and Assessment System (ICDAS-II), developmental defects of enamel (DDE) by the DDE index, and oral hygiene by the debris (DI), calculus (CI), and simplifed oral hygiene (OHI-S) indices. Results The median number of DMFT/dmft was 1.00 (interquartile range (IQR):1.00–4.00) in children with stage 1–3 CKD, 0.00 (IQR: 0.00–2.50) in stage 4–5 children, 0.00 (IQR: 1.00–3.00) in KTR, and 8.00 (IQR: 1.00–13.00) in healthy children. According to ICDAS-II categories, the percentage of children with severe caries was 53.8% in healthy children, while it was 44.4% in KTR, 25.9% in stage 1–3, and 11.4% in stage 4–5 children. While the percentage of children with DDE was 88.8% in KTR, 80% in stage 4–5, and 66.7% in stage 1–3 children, this rate was 44.2% in healthy children. The highest mean OHI-S score was observed in stage 4–5 children (2.10±1.08), followed by KTR (1.46±1.19), stage 1–3 (1.27±0.61), and healthy children (0.45±0.44), respectively. Conclusions Compared to healthy children, children with CKD had more debris accumulation, calculus formation, and more DDE but a lower severity of dental caries.Publication Metadata only A late onset uveıtıs after tubuloıntertıtıal nephrıtıs and uveıt (tınu) syndrome(2022-11-01) DEMİRCİ BODUR, ECE; GÖKCE, İBRAHİM; BAYRAKTAR, SEZİN; YILDIZ, NURDAN; ALPAY, HARİKA; DEMİRCİ BODUR E., GÖKCE İ., BAYRAKTAR S., Pul S., Turkkan O. N. , Guven S., Cicek N., YILDIZ N., ALPAY H.Publication Metadata only The relatıonshıp between ınsulın resıstance and serum adıpokıne levels ın chıldren wıth chronıc renal dısease receıvıng perıtoneal dıalysıs(2022-11-01) BİLGÜN, CEREN; YILDIZ, NURDAN; HAKLAR, GONCAGÜL; ALPAY, HARİKA; BİLGÜN C., YILDIZ N., Yaman A., HAKLAR G., ALPAY H.Publication Open Access Recurrent acute kıdney ınjury due to thrombosıs of the vena cava ınferıor(2022-11-01) DEMİRCİ BODUR, ECE; YILDIZ, NURDAN; TRUE, ÖMER; ALPAY, HARİKA; GÖKCE, İBRAHİM; Turkkan O. N. , GÖKCE İ., Barlas B., Pul S., DEMİRCİ BODUR E., Guven S., Cicek N., YILDIZ N., DOĞRU Ö., ALPAY H.Rationale: Acute kidney injury (AKI) is a frequent complication after liver transplantation. In some patients, prompt intervention targeted at a specific etiology is of paramount importance.Presenting concerns of the patients: A 25 years old man with advanced liver cirrhosis caused by sclerosing cholangitis and autoimmune hepatitis underwent orthotopic liver transplantation. One month after surgery, severe AKI developed in conjunction with recurrent ascites and lower extremity edema. Notable clinical findings included a persistently low urinary sodium excretion, a bland urinary sediment, and an abnormally monophasic hepatic vein waveform on Doppler ultrasound.Diagnoses: Inferior vena cava stenosis.Interventions: Angioplasty with stent installation.Outcomes: Rapid improvement of renal function after stent installation.Lessons learned: The following case illustrates the importance of integrating clinical cues, ultrasound features, and laboratory findings. The combination of AKI associated with lower extremity edema, abnormal monophasic hepatic vein flow on Doppler ultrasound, and a low urinary sodium excretion after liver transplantation should evoke the possibility of inferior vena cava stenosis as the etiologic factor.Publication Metadata only Genetıc tests ın non-neurogenıc neurogenıc bladder: two sıblıngs wıth ochoa syndrome(2022-11-01) GÖKCE, İBRAHİM; ALAVANDA, CEREN; ŞEKERCİ, ÇAĞRI AKIN; DEMİRCİ BODUR, ECE; YILDIZ, NURDAN; YÜCEL, SELÇUK; ATA, PINAR; ALPAY, HARİKA; Pul S., GÖKCE İ., ALAVANDA C., ŞEKERCİ Ç. A. , DEMİRCİ BODUR E., Turkkan O. N. , Guven S., Cicek N., YILDIZ N., YÜCEL S., et al.