Person: AKALIN, FİGEN
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
AKALIN
First Name
FİGEN
Name
13 results
Search Results
Now showing 1 - 10 of 13
Publication Metadata only Topsy-Turvy Heart: A Very Rare Congenital Rotational Heart Disease With Tracheobronchial Anomalies(2013) AKALIN, FİGEN; Erek E., Guzeltas A., Ozturk N.Y., Kiyan G., Karakoc F., Akalin F., Odemis E., Arsan S.The topsy-turvy heart is characterized by a global 90°clockwise rotation around the heart’s long axis. This rotation displaces all basal great arteries inferiorly and posteriorly, resulting in elongation and stretching of the brachiocephalic arteries and the bronchi. To date, reports of only four living cases have been published in the literature. We report here three new cases, with additional aortopulmonary window defects, and present their morphological details, clinical presentations, and our management. © 2013, SAGE Publications. All rights reserved.Publication Open Access Familial early infantile epileptic encephalopathy and cardiac conduction disorder: A rare cause of SUDEP in infancy(W B SAUNDERS CO LTD, 2017-08) TÜRKDOĞAN, DİLŞAD; Turkdogan, Dilsad; Usluer, Sunay; Akalin, Figen; Agyuz, Umut; Aslan, Elif SibelPublication Metadata only Chronic granulomatous disease: is it always associated with infections?(2012-01-01) BARIŞ, SAFA; AKALIN, FİGEN; BARIŞ S., Cagan H. H. , KIYKIM A., AKALIN F., Barlan I. B.Chronic granulomatous disease (CGD) is a rare disease of the phagocytic system characterized by mutation in nicotinamide adenine dinucleotide phosphate oxidase enzyme system. The heredity of disease is heterogeneous and X-linked genotype accounts for the most common type (65-70%). In patients with CGD reduction of reactive oxygen intermediates in phagocytes have result in susceptibility to catalase positive bacterial and fungal infections and abscess formation. Pericardial effusion and CGD coexistence is very rare condition and may occur during invasive fungal infections or secondary to enhanced inflammation. Twenty-month-old boy presented with fever and palpitation. On physical examination tachycardia and pericardial effusion was revealed (width: 11 mm) and his history was notable for perianal abscess in newborn period. Therefore, CGD was included in the differential diagnosis which was confirmed by nitroblue tetrazolium and dihidrorhodamin test. Despite negativity of microbiological culture for bacterial and fungal microorganisms the patient was placed on broad-spectrum antibacterial, antifungal and anti-inflammatory treatment. His condition improved without any complication. In this report, we emphasize that in patient with CGD pericardial effusion may be occurred secondary to increased inflammation without any microbial causes and can be resolved during clinical follow-up.Publication Open Access Coronary Arteriovenous Fistula Causing Hydrops Fetalis(2014) AKALIN, FİGEN; Cetiner, Nilüfer; Altunyuva Usta, Sinem; Akalın, FigenFetal heart failure and hydrops fetalis may occur due to systemic arteriovenous fistula because of increased cardiac output. Arteriovenous fistula of the central nervous system, liver, bone or vascular tumors such as sacrococcygeal teratoma were previously reported to be causes of intrauterine heart failure. However, coronary arteriovenous fistula was not reported as a cause of fetal heart failure previously. It is a rare pathology comprising 0.2-0.4% of all congenital heart diseases even during postnatal life. Some may remain asymptomatic for many years and diagnosed by auscultation of a continuous murmur during a routine examination, while a larger fistulous coronary artery opening to a low pressure cardiac chamber may cause ischemia of the affected myocardial region due to steal phenomenon and may present with cardiomyopathy or congestive heart failure during childhood. We herein report a neonate with coronary arteriovenous fistula between the left main coronary artery and the right ventricular apex, who presented with hydrops fetalis during the third trimester of pregnancy.Publication Metadata only Assessment of cardiac and vessel functions in childhood psoriasis(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2019) ŞAYLAN ÇEVİK, BERNA; Saylan Cevik, Berna; Akalin, Figen; Erolu, Elif; Gencosmanoolu, Seckin; Ergun, TulinBackground/aim: Psoriasis is a chronic inflammatory disease. The effect of psoriasis on the cardiovascular system has not been studied in children before. We studied ventricular strain and vascular functions to assess early cardiovascular effects of psoriasis during childhood. Materials and methods: The study population consisted of 20 psoriatic and 20 age- and sex-matched control subjects. Two-dimensional echocardiography images, longitudinal and global strain, and carotid and brachial ultrasound studies were performed. Results: The mean age of psoriatic children was 14 +/- 0.89 years and that of the controls was 14.05 +/- 0.88. There were significant increases in terms of interventricular septum diastolic and left ventricular posterior wall diastolic diameter and decreases in mitral E, mitral A, and E/A values between groups. Tissue Doppler imaging revealed significant differences between groups in terms of lateral annulus E', A', E'/A, isovolumetric contraction time, and ejection time. Aortic stiffness was significantly higher and global circumferential strain and longitudinal strain were significantly lower in the psoriasis group. Carotid intima media thickness and flow-mediated dilatation did not differ significantly between the groups. Conclusion: Cardiac left ventricular and arterial functions are affected in psoriatic children and may be an alarming sign of atherosclerotic heart disease in the long term. Early detection of these changes may be helpful for eliminating other risk factors.Publication Metadata only Arrhythmogenic right ventricular dysplasia, cutaneous manifestations and desmoplakin mutation: Carvajal syndrome(WILEY, 2018) ŞAYLAN ÇEVİK, BERNA; Erolu, Elif; Akalin, Figen; Cevik, Berna Saylan; Yucelten, DenizPublication Metadata only Disseminated Peripheral Mycotic Aneurysms and Septic Embolizations Related to an Infected Stent Deployed for Restenosis of Surgically Repaired Supravalvular Aortic Stenosis(SAGE PUBLICATIONS INC, 2016) ŞAYLAN ÇEVİK, BERNA; Ak, Koray; Akalin, Figen; Cevik, Berna Saylan; Isbir, Selim; Arsan, SinanPercutaneous treatment of supravalvular aortic stenosis (SVAS) by means of balloon dilation and stent deployment has been rarely reported in the literature. In this report, we present the case of a patient with mycotic aneurysms, disseminated peripheral and cerebral septic embolizations, and infected vegetations associated with a stent that had previously been deployed to treat restenosis of surgically corrected SVAS in the infancy.Publication Metadata only Results of pericardiectomy for constrictive pericarditis Single-center experience(URBAN & VOGEL, 2017) AKALIN, FİGEN; Ak, K.; Demirbas, E.; Atas, H.; Birkan, Y.; Akalin, F.; Cobanoglu, A.; Arsan, S.; Isbir, S.We evaluated our early and late outcomes after pericardiectomy in patients with constrictive pericarditis (CP). We retrospectively reviewed 31 patients who underwent pericardiectomy for CP from 1997 to 2015. Their mean age was 49.2 +/- 18.5 years and 74.2 % of them were male. The vast majority had severe functional impairment (NYHA class III-IV) with a mean duration of symptoms of 14.2 +/- 10.1 months. Early mortality was 9.7 %: n = 3; multiorgan failure (MOF) in 1, respiratory failure in 1, and left heart failure in 1. Preoperative systolic pulmonary artery pressure over 60 mmHg (p = 0.038, odds ratio [OR] = 0.12) and postoperative low cardiac output syndrome (p = 0.005, OR = 13.5) were significant predictors of early mortality in univariate analysis. Mean follow-up time was 57.8 +/- 61.9 months (4-216 months). Late mortality was 6.8 % (2/28 patients) and the cause was MOF secondary to end-stage right heart failure. In Kaplan-Meier analyses, actuarial (including early mortality) and event-free survival rates were 83.9 and 51.1 % at 216 months, respectively. At the end of follow-up, the majority of patients (23/26, 92.9 %) were in good functional status (NYHA class I-II). There were fewer patients under diuretic therapy in the postoperative than in the preoperative period; however, the difference was not statistically significant (12/31 vs. 4/26, p = 0.76). There was no significant difference between the preoperative and follow-up tricuspid annular plane systolic excursion values (15.5 +/- 2.2 and 16.6 +/- 2.2 mm, respectively, p = 0.088). Left ventricular systolic function was preserved in all patients postoperatively. Although early mortality after pericardiectomy remains high, the procedure provides significant improvement in functional status in the long term.Publication Metadata only Cardiac effects of granisetron in a prospective crossover randomized dose comparison trial(SPRINGER, 2012) AKALIN, FİGEN; Cakir, F. B.; Yapar, O.; Canpolat, C.; Akalin, F.; Berrak, S. G.Cardiac side effects of granisetron have been studied mostly in adult patients that are using cardiotoxic chemotherapeutics. There is limited evidence in pediatric age group and no information in pediatric oncology patients with non-cardiotoxic chemotherapeutics. In this prospective, crossover randomized study, the cardiac side effects of granisetron are compared in pediatric oncology patients who had carboplatin based chemotherapy. They were randomized to receive either 10 or 40 mu g kg(-1) dose(-1) of granisetron before each cycle of chemotherapy. We drew blood for creatine phosphokinase (CPK), CPK-muscle band (MB) and Troponin-T before and 24 h after administering granisetron. Electrocardiography (ECG) tracings were taken at 0, 1, 2, 3, 6 and 24 h of granisetron. Twenty-four hours Holter ECG monitorisation was performed after each granisetron infusion. A total of 16 patients (median 8.7 years of age) were treated with weekly consecutive courses of carboplatin. There was bradycardia (p = 0.000) in patients that had granisetron at 40 mu g/kg and PR interval was shortened in patients that had granisetron at 10 mu g/kg dose (p = 0.021). At both doses of granisetron, QTc interval and dispersion were found to be similar. CPK, CK-MB and Troponin-T values were found to be normal before and 24 h after granisetron infusion. As the first study that has studied cardiac side effects of granisetron in patients that are not using cardiotoxic chemotherapeutics, we conclude that granisetron at 40 mu g kg(-1) dose(-1) causes bradycardia only. We have also demonstrated that granisetron does not cause any clinically cardiac side effects either at 10 or 40 mu g kg(-1) dose(-1). However, our results should be supported by prospective randomized studies with larger samples of patient groups.Publication Metadata only Diaphragmatic paralysis after pediatric heart surgery: Usefulness of non-invasive ventilation(ELSEVIER IRELAND LTD, 2010) KARADAĞ, BÜLENT TANER; Oktem, Sedat; Cakir, Erkan; Uyan, Zeynep Seda; Karadag, Bulent; Hamutcu, Refika Ersu; Kiyan, Gursu; Akalin, Figen; Karakoc, Fazilet; Dagli, ElifDiaphragmatic paralysis after cardiac surgery is an important complication especially in infants. We report a child who developed diaphragmatic paralysis, atelectasis, bronchomalasia and respiratory failure following cardiac surgery. Ventilatory support alleviated respiratory distress in this child. This report illustrates the usefulness of invasive and non-invasive ventilatory support for a pediatric patient with diaphragmatic paralysis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.