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KERİMOĞLU, OYA

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KERİMOĞLU

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2015 - 20173
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    Nanocarriers: Novel Approaches to Oral Delivery of Insulin
    (MARMARA UNIV, INST HEALTH SCIENCES, 2017) KERİMOĞLU, OYA; Ozer, Setenay; Kerimoglu, Oya; Ugurlu, Timucin
    Diabetes is among the major chronic diseases at present, and no medication has been developed that can replace the roles of endogenous insulin, especially for type 1 diabetes patients. However, insulin can be frequently administered by the subcutaneous route as a protein macromolecule because enzymatic and absorption-associated problems. It leads to immunogenic symptoms, adipose tissue complaints such as lipodystrophy, and hyperinsulinemia risks because of pharmacokinetic properties that do exactly overlap with those of endogenous insulin. In a remarkable number of patients, failure to attain permanent glycemic control by subcutaneous insulin treatment has shown by clinical trials based on noncompliance. Oral drug administration has always been the most preferred administration pathway for drugs with high patient compliance and convenience. Difficulties in the use of subcutaneous insulin have prompted scientists to find solutions for the oral administration of insulin. Similar to many other fields, nanotechnology has recently come to the fore in the pharmaceutical field. Compared with conventional systems, nanopharmaceuticals are drug delivery systems that enable promoted absorption, protection of the active ingredient from the external environment, lower dose applications, higher bioavailability, controlled release, and prolonged residence time. In vitro and in vivo studies have been performed with varied nanopharmaceutical systems in order to administer insulin orally for this purpose.
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    Multilayered Tablet Technology, Manufacturing Process, Evaluation and its Application Areas
    (MARMARA UNIV, FAC MEDICINE, 2016) KERİMOĞLU, OYA; Canbagi, Hatice; Ugurlu, Timucin; Kerimoglu, Oya
    According to new developed technologies, drug industry is also trying to refresh and improve itself. With the conception of rational pharmacotherapy, new technologies becomes smarter than finding new active substances. Correspondingly as a new dosage system, multi-layer tablets that improved to serve this purpose, provides ease of use to patients, reduces the side effects and increases of effectiveness of active agent. Therefore multi-layer tablets are developed to improve both the quality of product and life. Conducted work studied for understanding the bi-layer tablet technique, evaluating the assesment parameters and to giving examples to used spaces.
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    Dendrimers-drug delivery systems
    (AVES PRESS LTD, 2015) KERİMOĞLU, OYA; Karabulut, Busra; Kerimoglu, Oya; Ugurlu, Timucin
    Dendrimers consisting a core, branching units around the core and surface groups also named as functional group are new polymeric drug delivery systems. The variety of dendrimers are provided with functional groups. Branching units of the dendrimer provide its growth iteratively. The space in the interior of the dendrimers allows encapsulation of the active ingredient possible. In this way, the controlled release of the active ingredient can be achieved. However, being in a very branched structure and having many functional groups on the surface provide the addition of variety of molecules and active ingredient by conjugation simultaneously. Thus, targeting of active ingredients to a specific site of the body can be achieved as well as the solubility and bioavailability of the active ingredients can be increased. In this paper, the properties of dendrimers and application areas were evaluated.