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KAYA, MİTHAT

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KAYA

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MİTHAT

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Now showing 1 - 3 of 3
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    PublicationOpen Access
    A case of granulomatosis of polyangiitis presenting with COVID-19 infection: False-positivity or co-existence?
    (2023-09-29) KAYA, MİTHAT; GÖKCE, İBRAHİM; ALPAY, HARİKA; KAYA M., GÖKCE İ., Guven S., Pul S., ALPAY H.
    Coronavirus disease 2019 (COVID-19) was declared a global pandemic and a public health emergency worldwide in March 2020. COVID-19 presents with non-specific symptoms of the upper airway and pulmonary system, which can overlap with other diseases involving the respiratory system as granulomatosis with polyangiitis (GPA). Both diseases have high morbidity and mortality rates and it is important to promptly differentiate and treat them. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) is currently the recommended method for diagnosing COVID-19. Antibody-based tests are used to diagnose both pat and current COVID-19 infections. We present a previously healthy thirteen-year-old girl who was admitted with upper airway symptoms and pulmonary involvement, and progressed to acute kidney failure. Laboratory findings showed leukocytosis, anemia, elevated kidney function tests and 2+ proteinuria. Computed tomography (CT) of the lungs showed multiple nodules, cavities, and ground-glass opacities (GGOs). We performed RT-PCR tests for COVID-19 for three times. Results were all negative, but the COVID-19 immunoglobulin (Ig)M test sent simultaneously was positive. Based on the cytoplasmic antineutrophilic cytoplasmic antibody (c-ANCA) positivity, upper airway, pulmonary, and renal involvement, she was diagnosed as GPA. This report highlights that COVID-19 antibody tests can be false-positive in patients with autoimmune diseases including GPA.
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    PublicationOpen Access
    Comparison of tension band wiring method applied with k-wire or cannulated screw in mayo 2A olecranon fracture fixation: A biomechanical study mayo 2A olecranon kırık tespitinde K-teli veya kanüllü vida ile uygulanan gergi bantlama metodunun karşılaştırması: biyomekanik çalışma
    (2022-01-01) KAYA, MİTHAT; KAYA M., Ertem F.
    © 2022, Duzce University Medical School. All rights reserved.Aim: The study aimed to compare the biomechanical stability and strength of the tension band wiring method used to treat mayo 2A olecranon fractures with Kirschner (K)-wire or cannulated screw configurations. Material and Methods: A total of 24 anatomical ulna models (Sawbones Model 1004, Pacific Research Laboratories, Vashon Island, WA) used in the study were divided into two equal groups of 12, tension band fixation with K-wire (Group 1) and tension band fixation with cannulated screw (Group 2), and groups were compared. The mechanical comparison was performed with a universal measuring machine (Shimadzu Autograph 50 kN; Shimadzu Corp). Results: Fixation methods comparison (K-wire/cannulated screw) were the main factors that determined the stability and the strength of the internal fixation. The median flexion strength of Group 1 was 107.92 (range, 94.22-121.72) N, and that of Group 2 was 109.67 (range, 105.07-113.86) N. The median varus strength of Group 1 was 100.02 (range, 83.24-102.18) N, and that of Group 2 was 76.32 (range, 68.44-78.43) N. Varus strength and stiffness were significantly higher in the K-wire group than in the cannulated screw group (both p values were <0.001). No significant differences were detected between the groups regarding flexion strength and stiffness (both p values were 0.999). Conclusion: Although no significant differences were detected between the two fixations in flexion bending cyclic loading, a significantly more stable fixation was achieved in tension banding applied with K-wire in varus bending cyclic loading. No reduction loss was detected during cyclic loading tests in either technique.
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    PublicationOpen Access
    Collapsing Glomerulopathy in a Patient with a TRPC6 Mutation Presenting as Rapidly Progressive Glomerulonephritis: A Case Report and Review of the Literature
    (2023-01-01) GÖKCE, İBRAHİM; KAYA, MİTHAT; ÇİÇEK DENİZ, NESLİHAN; YILDIZ, NURDAN; KAYA, HANDAN; ALPAY, HARİKA; GÖKCE İ., KAYA M., ÇİÇEK N., Guven S., Ercetin Y., YILDIZ N., KAYA H., ALPAY H.
    Collapsing glomerulopathy (CG) is a proliferative disease characterized by segmental or global wrinkling of the glomerular basement membrane and the formation of pseudocrescents, whereas focal segmental glomerulosclerosis (FSGS) is characterized by podocytopenia, and focal and segmental sclerosis of the glomeruli. Mutations in NPHS1, NPHS2, WT1, PLCE1, CD2AP, ACTN4, and TRPC6 have been reported in steroid-resistant FSGS patients. The mutations p.R895C and p.R895L in Exon 13 are the only ones in TRPC6 causing CG reported to date. Here, we present the case of a 17-year-old male patient with a collapsing variant of familial FSGS caused by a mutation in TRPC6 (p.R895C) who presented with rapidly progressive (crescentic) and proliferative glomerulonephritis.