Person: YILDIRIM, HATİCE SELİN
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YILDIRIM
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HATİCE SELİN
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Publication Metadata only Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial(AMER ACAD PERIODONTOLOGY, 2018) DOĞAN, BAŞAK; Yildirim, Selin; Ozener, Hafize Ozturk; Dogan, Basak; Kuru, BaharBackground: This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery. Methods: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42. Results: Test groups experienced less pain than the control group on days 3 and 7 (P < 0.001 and P < 0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P < 0.001 and P < 0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively). Conclusion: Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match.Publication Open Access Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects(HINDAWI LTD, 2018-06-28) ÖZBEYLİ, DİLEK; Agrali, Omer B.; Yildirim, Selin; Ozener, Hafize O.; Kose, Kemal N.; Ozbeyli, Dilek; Soluk-Tekkesin, Merva; Kuru, LeylaHyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats. In the same rats, the other defect was treated with HA matrix alone. One of the 2 defects formed in other 8 rats was treated with HA + G and the other with HA + M. One of the 2 defects formed in the remaining 8 rats was treated wilh G+M and the other with HA+G+M. The animals were sacrificed at 4 weeks. Histologic, histomorphometric, and immunohistochemical analyses were performed. Both HA matrix alone and its combinalions with G and M supported new bone formation (NBF). However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P < 0.00l). Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them. Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.Publication Metadata only Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats(2023-09-01) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.Publication Metadata only Rat kalvaryal defektlerinde D3 vitamininin yönlendirilmiş kemik rejenerasyonu üzerine etkisinin değerlendirilmesi(2022-11-06) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.Amaç: Bu çalışmada oral yolla verilen D3 vitamininin ratlarda yönlendirilmiş kemik rejenerasyonuna etkisinin histolojik olarak değerlendirilmesi amaçlandı. Gereç-Yöntem: Çalışma 12 adet erişkin erkek SpragueDawley cinsi rat üzerinde gerçekleştirildi. Tüm ratların kalvaryal kemiklerinde 5 mm çapında oluşturulan defektlere sığır kaynaklı kemik grefti (BioOss®) ile birlikte kolajen esaslı rezorbe olabilen membran (BioGide®) uygulandı. Cerrahi sonrası ratlar rastgele iki gruba ayrıldı; birinci gruba (Kontrol Grubu) distile su, ikinci gruba (Test Grubu) ise 2 µg /kg D3 vitamini günde 1 kez olmak üzere gavajla 8 hafta boyunca verildi. 8 haftanın sonunda ratlar sakrifiye edildi. Hematoksilen-Eozin ile boyanan örnekler histolojik olarak incelendi. ImageJ yazılım programı kullanılarak yeni kemik, rezidüel greft ve fibröz doku alanları hesaplandı. Verilerin istatistiksel analizleri GraphPad Prism programında değerlendirildi. İstatistiksel anlamlılık p<0,05 olarak kabul edildi. Bulgular: Yeni kemik alan yüzdesinin test grubunda (%43,75) kontrol grubundan (%28,35) istatistiksel olarak anlamlı yüksek olduğu tespit edildi (p<0,05). Rezidüel greft alanı, test grubunda 0,56 ±0,21 mm2 iken kontrol grubunda 0,89±0,17 mm2 olarak saptandı (p<0,05). Fibröz doku alanının, test grubu (1,00±0,27 mm2) ile kontrol grubunda (1,10±0,23 mm2) benzer olduğu gözlendi (p>0,05). Sonuç: Bu çalışmanın sonuçları, yönlendirilmiş kemik rejenerasyonunu takiben oral yolla kullanılan D3 vitamininin ratların kritik boyuttaki kalvaryal defektlerinde yeni kemik dokusu oluşumunu artırdığını göstermiştir.Publication Open Access Single nucleotide polymorphisms in IL-1A RS1800587, IL-1B RS1143634 and vitamin D receptor rs731236 in stage III grade B/C periodontitis(2022-06-01) ÖZTÜRK ÖZENER, HAFİZE; ASLAN, BEGÜM; AĞRALI, ÖMER BİRKAN; ULUCAN, KORKUT; YILDIRIM, HATİCE SELİN; KURU, LEYLA; Ozener H., ASLAN B., Eken B. F., AĞRALI Ö. B., Yildrim H. S., Altunok E. C., ULUCAN K., KURU L.The purpose of the study is to determine the prevalence of interleukin (IL)-1A (rs1800587), IL-1B (rs1143634) and vitamin D receptor (VDR) (TaqI, rs731236) gene polymorphisms in the Turkish population and their association with Stage III Grade B/C periodontitis. Systemically and periodontally healthy individuals (N = 100) and Stage III Grade B/C periodontitis patients (N=100) based on clinical and radiographic examination were included in this research. Clinical attachment level, probing depth, bleeding on probing, plaque and gingival indices of the subjects were measured. Genotyping of IL-1A (rs1800587), IL-1B (rs1143634) and VDR (rs731236) polymorphisms was conducted by Real Time PCR. Allelic and genotypic distributions of IL-1A (rs1800587) gene polymorphism were not associated with periodontitis (p > 0.05). In IL-1B (rs1143634) gene polymorphism, the C allele was detected more frequently in healthy individuals compared with the periodontitis patients (p=0.045). CC genotype and C allele in VDR (rs731236) gene polymorphism was higher in periodontitis patients (p=0.031, p=0.034, respectively). In comparison with Grade B periodontitis patients and healthy subjects, CC genotype and C allele were observed more frequently in the Grade B periodontitis in terms of alleles (C/T) and genotypes for VDR (rs731236) polymorphism (p=0.024, p=0.008, respectively). This study presents that the VDR (rs731236) polymorphism are associated with enhanced susceptibility to Stage III periodontitis in the Turkish population. Furthermore, VDR (rs731236) polymorphism may be used as an identification criteria to discriminate Grade B and Grade C in Stage III periodontitis.