Person: İNAN, AHMET TALAT
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İNAN
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AHMET TALAT
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Publication Metadata only 3D bio-printing of levan/polycaprolactone/gelatin blends for bone tissue engineering: Characterization of the cellular behavior(PERGAMON-ELSEVIER SCIENCE LTD, 2019) İNAN, AHMET TALAT; Duymaz, Busra Tugce; Erdiler, Fatma Betul; Alan, Tugba; Aydogdu, Mehmet Onur; Inan, Ahmet Talat; Ekren, Nazmi; Uzun, Muhammet; Sahin, Yesim Muge; Bulus, Erdi; Oktar, Faik Nuzhet; Selvi, Sinem Selvin; ToksoyOner, Ebru; Kilic, Osman; Bostan, Muge Sennaroglu; Eroglu, Mehmet Sayip; Gunduz, OguzhanPoly(epsilon-caprolactone) (PCL), gelatin (GT) and different concentrations of low molecular weight Halomonas levan (HLh) were combined and examined to develop physical networks serving as tissue scaffolds to promote cell adhesion for biocompatibility. Three-dimensional bioprinting technique (3D bioprinting) was employed during manufacturing the test samples and their comprehensive characterization was performed to investigate the physicochemical properties and biocompatibility. Physical properties of the printing materials such as viscosity, surface tension, and density were measured to determine optimal parameters for 3D bioprinting. The scanning electron microscope (SEM) was used to observe the morphological structure of scaffolds. Fourier-Transform Infrared Spectroscopy (FT-IR) and differential scanning calorimetry (DSC) were used to identify the interactions between the components. In-vitro cell culture assays using standard human osteoblast (Hob) cells showed increased biocompatibility of the printing materials with increasing HLh content. Thus, the formulations including the HLh are expected to be a good candidate for the production of 3D printed materials.