Person: OKTAR, FAİK NÜZHET
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OKTAR
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FAİK NÜZHET
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Publication Metadata only Investigation of 3D-Printed Polycaprolactone-/Polyvinylpyrrolidone-Based Constructs(SAGE PUBLICATIONS INC) ŞAHİN, ALİ; Izgordu, Muhammet Sefa; Uzgur, Evren Isa; Ulag, Songul; Sahin, Ali; Yilmaz, Betul Karademir; Kilic, Beyhan; Ekren, Nazmi; Oktar, Faik Nuzhet; Gunduz, OguzhanThe aim of this study is to evaluate the mechanical and biological performance of cartilage-like constructs produced by 3D printing. During the investigation, poly(epsilon-caprolactone) (PCL) and polyvinylpyrrolidone (PVP) were used as a matrix polymer and low-molecular-weight chitosan (CS), hyaluronic acid (HA), and alginic acid sodium salt (SA) were integrated separately with the polymer matrix to fabricate the constructs. Thermal, mechanical, morphology, and chemical properties and swelling, degradation, and biocompatibility behaviors were evaluated in detail. With the addition of 3 fillers, the melting temperature of the matrix increased with the addition of fillers, and PCL/3wt.%PVP/1wt.%HA had the highest melting temperature value. Mechanical characterization results demonstrated that the printed PCL/3wt.%PVP/1wt.%CS displayed the highest compressive strength of around 9.51 MPa. The compressive strength difference between the PCL/3wt.%PVP and PCL/3wt.%PVP/1wt.%CS was 5.38 MPa. Biocompatibility properties of the constructs were tested by mitochondrial dehydrogenase activity, and in vitro studies showed that the PCL/3wt.%PVP/1wt.%HA composite construct had more cell viability than the other constructs by making use of the mesenchymal stem cell line.Publication Metadata only Production and characterization of electrospun fish sarcoplasmic protein based nanofibers(ELSEVIER SCI LTD, 2018) KAZAN, DİLEK; Sahin, Yesim M.; Su, Sena; Ozbek, Burak; Yucel, Sevil; Pinar, Orkun; Kazan, Dilek; Oktar, Faik N.; Ekren, Nazmi; Gunduz, OguzhanIn this study, poly (e-caprolactone) (PCL) and fish sarcoplasmic protein (FSP) (Mw < 200 kDa) composite nanofibers were fabricated by electrospinning technique. Solution properties such as density, viscosity, conductivity and surface tension were studied as a function of FSP content in the solution. The morphology, molecular interaction, degradation as well as thermal and tensile properties of PCL/FSP nanofibers were investigated. The results show that smooth and beadless PCL/FSP nanofibers with the diameters ranging from 120 +/- 29 nm to 139 +/- 41 nm were obtained. The average diameters decreased and the diameter distributions narrowed with the addition of optimum FSP amount. The characteristic picks of FSP and PCL were identified in the composite nanofibers by structural analyses. PCL/FSP nanofibers exhibited high degradation ability in comparison to electrospun pure PCL nancifibers. Moreover, the PCL/FSP nanofibers exhibit good mechanical properties (tensile strength of 5.55 MPa) with the additional FSP content. (C) 2017 Elsevier Ltd. All rights reserved.Publication Metadata only Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering(AUSTRALIAN CERAMIC SOCIETY, 2018) OKTAR, FAİK NÜZHET; Ozbek, Burak; Erdogan, Barkin; Ekren, Nazmi; Oktar, Faik Nuzhet; Akyol, Sibel; Ben-Nissan, Besim; Sasmazel, Hilal Turkoglu; Kalkandelen, Cevriye; Mergen, Ayhan; Kuruca, Serap Erdem; Ozen, Gunes; Gunduz, OguzhanNanofibrous composites of the poly(epsilon-caprolactone) (PCL), tricalcium phosphate (TCP), and hexagonal boron nitride (h-BN) with different compositions were manufactured by using an economical and non-complicated method called electrospinning. Produced fibrous structures showed no bead formation and had a clean surface. Characterization of the composites showed that particles were successfully mixed with polymer phase. High cell activity of SaOS-2 cells on the composites was observed with SEM images. In addition, fibrous scaffolds are biocompatible with human bone tissue and are highly degradable.Publication Open Access Electrospun Nanocomposite Materials, A Novel Synergy of Polyurethane and Bovine Derived Hydroxyapatite(IOP PUBLISHING LTD, 2017-04-21) OKTAR, FAİK NÜZHET; Bozkurt, Y.; Sahin, A.; Sunulu, A.; Aydogdu, M. O.; Altun, E.; Oktar, F. N.; Ekren, N.; Gunduz, O.; Tai, Y; Priyanka, SPolyurethane (PU) is a synthetic polymer that is used for construction of scaffold in tissue engineering applications in order to obtain desirable mechanical, physical and chemical properties like elasticity and durability. Bovine derived hydroxyapatite (BHAp) is a ceramic based natural polymer that is used as the most preferred implant material in orthopedics and dentistry due to their chemically and biologically similarity to the mineral phase found in the human bone structure. PU and bovine derived hydroxyapatite (BHAp) solutions with different concentrations were prepared with dissolving polyurethane and BHAp in Dimethylformamide (DMF) and Tetrahydrofuran (THF) solutions. Blended PU-BHAp solutions in different concentrations were used for electrospinning technique to create nanofiber scaffolds and new biocomposite material together. SEM, FTIR and physical analysis such as viscosity, electrical conductivity, density measurement and tensile strength measurement tests were carried out after production process.Publication Metadata only 3D bio-printing of levan/polycaprolactone/gelatin blends for bone tissue engineering: Characterization of the cellular behavior(PERGAMON-ELSEVIER SCIENCE LTD, 2019) İNAN, AHMET TALAT; Duymaz, Busra Tugce; Erdiler, Fatma Betul; Alan, Tugba; Aydogdu, Mehmet Onur; Inan, Ahmet Talat; Ekren, Nazmi; Uzun, Muhammet; Sahin, Yesim Muge; Bulus, Erdi; Oktar, Faik Nuzhet; Selvi, Sinem Selvin; ToksoyOner, Ebru; Kilic, Osman; Bostan, Muge Sennaroglu; Eroglu, Mehmet Sayip; Gunduz, OguzhanPoly(epsilon-caprolactone) (PCL), gelatin (GT) and different concentrations of low molecular weight Halomonas levan (HLh) were combined and examined to develop physical networks serving as tissue scaffolds to promote cell adhesion for biocompatibility. Three-dimensional bioprinting technique (3D bioprinting) was employed during manufacturing the test samples and their comprehensive characterization was performed to investigate the physicochemical properties and biocompatibility. Physical properties of the printing materials such as viscosity, surface tension, and density were measured to determine optimal parameters for 3D bioprinting. The scanning electron microscope (SEM) was used to observe the morphological structure of scaffolds. Fourier-Transform Infrared Spectroscopy (FT-IR) and differential scanning calorimetry (DSC) were used to identify the interactions between the components. In-vitro cell culture assays using standard human osteoblast (Hob) cells showed increased biocompatibility of the printing materials with increasing HLh content. Thus, the formulations including the HLh are expected to be a good candidate for the production of 3D printed materials.