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AKKAYA TURHAN, SEMRA

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AKKAYA TURHAN

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Subject: Sağlık Bilimleri ×

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    PublicationOpen Access
    Neuropsychological and clinical correlations of optical coherence tomography findings in patients with schizophrenia
    (2023-10-01) SAKALLI KANİ, AYŞE; ŞAHİN ÇAM, CANSUN; AKKAYA TURHAN, SEMRA; TOKER, AYŞE EBRU; YILDIZ, MESUT; Sakallı Kani A., Şahin Çam C., Çelik E. B., Dural Şenoğuz U., Duran M., Akkaya Turhan S., Toker A. E., Yıldız M.
    Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters. Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters. Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior (ρ = – .422, p <.05). STROOP response duration positively correlated with right RNFL on average (ρ = .551, p <.05), left RNFL on average (ρ = .498, p <.05), right RNFL superior (ρ = .507, p <.05), left RNFL superior (ρ = .461, p <.05) and right RNFL temporal values (ρ = .434, p <.05). STROOP response error was also positively correlated with right RNFL temporal thickness (ρ = .430, p <.05). STROOP response duration was positively correlated with right GCL total (ρ = .646, p <.01), right GCL superior (ρ = .658, p <.01) and right GCL inferior (ρ = .596, p <.01) thickness. Conclusion: We did not find a significant relationship between reduced RNFL or GCL thickness and cognitive impairment. However, we had several positive correlations between cognitive task scores and RNFL and GCL thicknesses. Additionally, our study did not correlate symptom severity and clinical severity parameters with reduced RNFL or GCL thickness
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    PublicationOpen Access
    Skin-only versus skin-plus-orbicularis resection blepharoplasty: an elaborated analysis of early- and long-term effects on corneal nerves, meibomian glands, dry eye parameters, and eyebrow position
    (2023-09-01) DERİCİOĞLU, VOLKAN; ŞAN, BURÇİN; SEVİK, MEHMET ORKUN; AKKAYA TURHAN, SEMRA; DERİCİOĞLU V., ŞAN B., SEVİK M. O., AKKAYA TURHAN S.
    Purpose: To evaluate the early- and long-term effects of 2 different blepharoplasty techniques on corneal nerves, meibomian gland morphology, clinical parameters of dry eye disease (DED), and eyebrow position. Methods: This prospective, interventional study included age-sex-matched blepharoplasty patients who had a skin-only resection (24 eyes of 12 patients; Group-S) or a skin-plus-orbicularis muscle resection (24 eyes of 12 patients; Group-M) procedure. Preoperative and postoperative parameters of in vivo corneal confocal microscopy (IVCCM; corneal nerve fiber density [CNFD], nerve branch density [CNBD], and nerve fiber length), meibomian gland area loss (MGAL), DED (Schirmer I test and noninvasive tear breakup time), and eyebrow heights (lateral [LBH] and central [CBH]) were evaluated and compared between the intervention groups (ClinicalTrials.gov, NCT05528016). Results: Compared with baseline, the CNBD of Group-S (19.91 ± 7.66 vs. 16.05 ± 7.28 branches/mm2, p = 0.049) and CNFD of Group-M (19.52 ± 7.45 vs. 16.80 ± 6.95 fibers/mm2, p = 0.028) was significantly decreased at postoperative first week. However, in both groups, IVCCM parameters returned to baseline values at postoperative first month and first year (p > 0.05). A significant MGAL increase was observed in Group-S (18.47 ± 5.43 vs. 19.94 ± 5.31, p = 0.030) and Group-M (18.86 ± 7.06 vs. 20.12 ± 7.01, p = 0.023) at the postoperative first year, demonstrating meibomian gland atrophy. Only significant changes were observed in Group-M in LBH (16.17 ± 2.45 vs. 16.67 ± 2.28 mm, p = 0.044) and CBH (17.33 ± 2.35 vs. 17.96 ± 2.31 mm, p = 0.004) at postoperative first year. Conclusions: Blepharoplasty with or without orbicularis resection seems to have similar effects on IVCCM, DED, and MGAL parameters. However, incorporating an orbicularis muscle resection in a blepharoplasty operation could slightly elevate the eyebrow position.