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KÖSE, KEMAL NACİ

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    Periferal Ossifiye Fibromun Preprotetik Periodontal Flep ile Tedavisi: Bir Olgu Sunumu
    (2022-11-06) KÖSE, KEMAL NACİ; Babalı S., Duman I., Çeşmecioğlu E., Köse K. N.
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    Peri-implantitis tedavisine modifiye periodontal yaklaşım: bir olgu sunumu
    (2022-11-06) KÖSE, KEMAL NACİ; İşlek İ., Köse K. N.
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    PublicationOpen Access
    Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects
    (HINDAWI LTD, 2018-06-28) ÖZBEYLİ, DİLEK; Agrali, Omer B.; Yildirim, Selin; Ozener, Hafize O.; Kose, Kemal N.; Ozbeyli, Dilek; Soluk-Tekkesin, Merva; Kuru, Leyla
    Hyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats. In the same rats, the other defect was treated with HA matrix alone. One of the 2 defects formed in other 8 rats was treated with HA + G and the other with HA + M. One of the 2 defects formed in the remaining 8 rats was treated wilh G+M and the other with HA+G+M. The animals were sacrificed at 4 weeks. Histologic, histomorphometric, and immunohistochemical analyses were performed. Both HA matrix alone and its combinalions with G and M supported new bone formation (NBF). However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P < 0.00l). Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them. Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.
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    Biyolojik yaşlanma ile ağız içi ve periodontal dokularda meydana gelen değişiklikler
    (Ortadoğu reklam tanıtım Yayıncılık turizm eğitim İnşaat Sanayi ve ticaret A.Ş., 2022-01-01) YILDIRIM, HATİCE SELİN; KÖSE, KEMAL NACİ; KURU, LEYLA; YILDIRIM H. S., KÖSE K. N., KURU L.
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    İyonik diş fırçasının ortodontik tedavi gören hastalarda ağız hijyeni üzerindeki etkisinin araştırılması.
    (1998-05-20) KÖSE, KEMAL NACİ; KADİR, TANJU; YILMAZ R. S., KÖSE K. N., EFEOĞLU E., Noyan U., KURU B., BİREN S., KADİR T.
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    The use of all-ceramic restorations to splint periodontally compromised teeth: A clinical report
    (MOSBY-ELSEVIER, 2005) KÖSE, KEMAL NACİ; Kuybulu, EO; Gemalmaz, D; Kose, KN
    This clinical report describes the use of an all-ceramic system to restore periodontally compromised teeth. A metal-free post-and-core system and all-ceramic crowns were used to splint the teeth and fulfill the esthetic demands.
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    The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study
    (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020) YILDIRIM, HATİCE SELİN; Kose, K. N.; Yilmaz, S.; Noyan, U.; Kuru, B.; Yildirim, H. S.; Agrali, O. B.; Ozener, H. O.; Kuru, L.
    Background: Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO). The growth factors may have a role in the pathogenesis of amlodipine-induced GO. Objectives: This pilot study aimed to investigate the growth factors including transforming growth factor-b1 (TGF-b1), platelet-derived growth factor-BB (PDGF-BB), and basic fibroblast growth factor (bFGF) in gingival crevicular fluid (GCF) of patients with amlodipine-induced GO and compare with of healthy subjects. Methods: GCF samples were collected from 56 sites presenting GO (GO + group) and from 38 sites not presenting GO (GO- group) of 5 patients using amlodipine for more than one year, and from 45 sites (control group) of 5 healthy subjects. The levels of TGF-b1, PDGF-BB, and bFGF were determined by using ELISA kits. Results: The mean concentration of TGF-b1 in GCF samples of GO + group (9.50 +/- 7.30 ng/ml) was higher than both GO- group (2.07 +/- 0.50 ng/ml) and control group (2.74 +/- 1.01 ng/ml) (P = 0.014). No significant difference was found among the groups in the GCF levels of PDGF-BB (P = 0.767). bFGF was detected in only 33% of the sites from patients. Conclusion: These preliminary results suggest that TGF-b1 may play a crucial role in the pathogenesis of amlodipine-induced GO.
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    Multidisciplinary approach in the treatment of subgingivally fractured anterior teeth
    (WILEY, 2008) KÖSE, KEMAL NACİ; Tuerker, Sebnem Beguem; Koese, Kemal Naci
    With the advances in adhesive technology, dentists have gained great popularity with their esthetics treatment options. The enamel and partially dentin adhesive systems have proved their potential effect. This study presents the multidisciplinary approach in the treatment of subgingivally fractured anterior teeth. Empress II crowns were cemented entirely on the prepared root portion of a left maxillary lateral incisor and canine after orthodontic eruption. The clinical results after 2 years were successful.
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    PublicationOpen Access
    Bifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: a randomized controlled clinical trial
    (2023-01-01) KURU, LEYLA; KADİR, TANJU; KÖSE, KEMAL NACİ; Özener H. Ö., KURU L., KADİR T., Kuru B.
    © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Objectives: The purpose of this study is to investigate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt as an adjunct to non-surgical periodontal treatment in periodontitis patients. Materials and methods: This is a prospective randomized controlled clinical study registered with NCT05408364 under clinical trial registration. Thirty periodontitis patients were divided into 2 groups at random. As adjunctive to supra and subgingival instrumentation, the test group consumed Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt while the control group consumed natural yogurt, once daily for 28 days. The plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 28th day, and 3rd month. Microbiological analysis was performed using culture method by obtaining subgingival plaque samples from 2 periodontal sites with 4≤PD≤6 mm at the same time points. Results: The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group. There were no significant differences in terms of PD and CAL changes between the study groups at all times (∆baseline–28 days, ∆baseline–3 months) (p>0.05). The number of patients presenting subgingival Bifidobacterium species was significantly greater in the test group than the control group at the 28th day (p<0.05). Conclusions: The administration of probiotics has shown beneficial effects, albeit limited, on clinical and microbiological outcomes in the management of periodontitis patients. Clinical relevance: Daily consumption of probiotic yogurt may be supportive for supra and subgingival instrumentation.
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    Tümüyle Dişsiz Bir Hastanın İmplant Destekli Protez ile Tedavisi İçin Ogmentasyonu: Bir Olgu Sunumu
    (2022-10-19) KAHRAMANOĞLU, ERKUT; KÖSE, KEMAL NACİ; Gündüz G., Cüce İ., Kahramanoğlu E., Köse K. N.
    AMAÇ: Total dişsiz hastaların protetik tedavisinde uygun olmayan yumuşak ve sert dokuların düzeltilerek protez için uygun hale getirilmesi hem başarılı bir tedavi için hem de hastanın sağlığı ve konforu için büyük öneme sahiptir. Bu olgu raporunda frenektomi, klasik serbest diş eti grefti ve akordeon tekniği kullanılan serbest diş eti greftlerinin kullanıldığı pre-protetik periodontal cerrahi ve sert doku düzeltilmesine yönelik osteoektomi/osteoplastinin kullanıldığı yüksek frenilum, sığ vestibule ve egzositozlara bağlı sert doku çıkıntıları olan bir hastanın tedavisi sunulmaktadır. OLGU SUNUMU: Kliniğimize önceki protezlerini kullanamama ve ağrı şikayetiyle gelen 56 yaşındaki sağlıklı kadın hastanın yapılan muayenesinde yüksek labial freniluma, sığ vestibüle ve düzensiz kemik çıkıntılarına sahip olduğu görüldü. Protez Anabilim Dalı ile konsültasyon sonrasında, öncelikle labial frenektomi ve tüm kadranlar için yumuşak dokuların frenektomi, serbest diş eti greftleri ve gerektiğinde accordion tekniği ile yapılan greftlemeler ile ogmentasyonu yapılmasına karar verildi. Üst çenesi, klasik hareketli total protez ile alt çenesi ise 4 implant destekli overdenture ile tedavisi tamamlanacaktır. Alt çenedeki mevcut sert doku çıkıntıları ise implant cerrahisi sırasında osteoektomi/osteoplasti ile uzaklaştırılacaktır. Frenektomi ve yumuşak doku cerrahilerinin tamamlanmasından 8 hafta sonra implantlar yerleştirildi ve ilgili bölgelerdeki sert doku düzensizlikleri düzeltildi. 3 aylık osseointegrasyon süresini takiben iyileşme vidalarının takıldığı ikinci cerrahi işlemleri yapıldı. 6 haftalık iyileşme periodu sonrasında protezlerinin yapılması için Protez bölümüne gönderildi. Protezlerin tamamlanmasından sonraki 1 yıl içerisinde hastanın çok rahatlıkla protezlerini kullandığı, herhangi bir şikâyetinin olmadığı görüldü. SONUÇ: Bu olgu sunumu, tümüyle dişsiz hastaların protetik rehabilitasyonunda başarılı bir tedavi için periodontal pre-protetik cerrahileri de içeren iyi planlanmış bir tedavi planlamasının yadsınamaz olduğunu desteklemektedir. Anahtar Kelimeler: Diş implantasyonu; Diş protezi; İmplant destekli; Mukogingival cerrahi; Serbest diş eti grefti