Person: KARGÜL, BETÜL
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KARGÜL
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BETÜL
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Publication Open Access Effect of Remineralization Agents on Molar-Incisor Hypomineralization-Affected Incisors: A Randomized Controlled Clinical Trial(2022-01-01) KARGÜL, BETÜL; SEZER B., KARGÜL B.Objective: The objective of this study was to evaluate the remineralization effect of two different mineral containing agents on white/creamy and yellow/brown demarcated opacities in incisors in children with molar-incisor hypomineralization (MIH) by using laser fluoresence (LF). Study Design: Fifty-three children (n=401 lesions) with MIH were randomly divided into three groups: (1)calcium glycerophosphate (CaGP), (2)casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) and, (3)control (1450 ppm fluoride toothpaste). Remineralization was evaluated by means of LF, at baseline, after one and threemonths. Anova Test for Repeated Measurements in intra-group comparisons in evaluating the effectiveness of remineralization agents. One-way Variance Analysis (ANOVA) and Tukey-Kramer Multiple Comparison test were used in the comparisons between groups and, Student Newman Keuls Multpile Comparison Test was used to determine the differences between the measurement averages in case of p<0.05. Results: There was a significant improvement in MIH-lesions over time in all groups (p<0.001), with no differences between groups. The highest percentage of change was observed in CPP-ACFP in lesions LF≤20 scores and the mean percentage of change LF>20 scores, the highest percentage changes in CaGP. There was no significant difference between the groups over the time for all the used outcome measures (p>0.05). Conclusion: The additional use of both mineral containing agents in MIH-affected teeth improved these hypomineralized lesions with mineral deposition. Even if both agents could be used in the hypomineralized teeth with demarcated opacities, future studies are recommended the long-term effect of these mineral containing agents with longer observation and a larger sample size. Keywords: Molar incisor hypomineralization, Calcium glycerophosphate, Casein phosphopeptideamorphous calcium phosphate nanocomplex, Tooth remineralization.Publication Metadata only Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study(2023-01-01) KAYA, REMZİYE; ALPAY, HARİKA; KARGÜL, BETÜL; SEZER B., Kodaman Dokumacıgil N., KAYA R., Güven S., Türkkan Ö. N., Çiçek N., ALPAY H., KARGÜL B.Objectives: The aim of this study was to investigate the association between serum biomarkers and oral health parameters in children with chronic kidney disease (CKD). Materials and methods: Serum hemoglobin, blood urea nitrogen, serum creatinine, calcium, parathormone, magnesium, and phosphorus levels were measured in 62 children with CKD aged between 4 and 17 years. Intraoral examinations of the patients were performed by two different pediatric dentists. Dental caries was assessed using the decayed-missing-filled-teeth (DMFT/dmft) indexes, and oral hygiene was assessed using the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indexes. Spearman’s rho coefficient and generalized linear modeling were used to examine the association between serum biomarkers and oral health parameters. Results: The results of the study showed that there were negative and statistically significant correlations between serum hemoglobin and creatinine levels and dmft scores in pediatric patients with CKD (p = 0.021 and p = 0.019, respectively). Furthermore, blood urea nitrogen levels and DI and OHI-S scores (p = 0.047 and p = 0.050, respectively); serum creatinine levels and DI, CI, and OHI-S scores (p = 0.005, p = 0.047, p = 0.043, respectively); and parathormone levels and CI and OHI-S scores (p = 0.001 and p = 0.017, respectively) were found to be positively and statistically significantly related. Conclusions: There are associations between various serum biomarker levels and dental caries and oral hygiene parameters in pediatric patients with CKD. Clinical relevance: The impact of changes in serum biomarkers on oral and dental health is important for dentists’ and medical professionals\" approaches to patients\" oral and systemic health.Publication Open Access Changes in oral health-related quality of life after treatment of molar incisor hypomineralisation using Glass Hybrid Restorations(2022-10-01) TUĞCU, NİHAN; SEZER, BERKANT; DURMUŞ, BAŞAK; KARGÜL, BETÜL; TUĞCU N., SEZER B., Caliskan C., DURMUŞ B., KARGÜL B.Objective: To assess the changes in children\"s oral health-related quality of life following the treatment of severely affected molar-incisor hypomineralisation with Glass Hybrid Restorative System (GH) after selective caries removal. Method: The observational cross-sectional study was conducted at the Marmara University, School of Dentistry, Department of Pediatric Dentistry, Istanbul, Turkey.. Children aged 11-14 years (n = 55) who were diagnosed with MIH and had finished their dental treatment from November 2018 to December 2019, were included. The children\"s MIH-affected teeth were treated with GH after SCR. Participants answered the Child Perceptions Questionnaire (CPQ11?14) prior to their dental treatment and 6 months after the treatment. Results: Of the fifty-five patients, 40 patients (24 girls-16 boys) completed baseline and follow-up data. The mean age of the children was 11.85 +/- 1.02 years. The overall CPQ score ranged from 3-83 (average 33.27 +/- 16.46) at baseline and 0-61 (average 11.67 +/- 11.21) at follow up. The emotional well-being among children was the highest score at baseline. A significant decrease (p < 0.001) in the mean values was observed for both the overall CPQ scores and for the scores of the oral symptoms, functional limitations, and social-emotional well-being limitation. All subdomains showed large effect sizes and oral symptom limitation domain presented the greatest effect. Wilcoxon Rank test was used to determine the statistical significance of the changes and the magnitude of change was determined by calculating and classifying the effect size. Conclusion: Restorative treatment with GH following selective caries removal positively influenced the oral health -related quality of life of children with severe molar-incisor hypomineralisation.Publication Open Access Is there an association between molar incisor hypomineralization and developmental dental anomalies? A case-control study(2023-12-01) ŞEN YAVUZ, BETÜL; KARGÜL, BETÜL; ŞEN YAVUZ B., SEZER B., Kaya R., Tuğcu N., KARGÜL B.Background: The aim of this study was to determine whether there is any association between molar incisor hypomineralization and developmental dental anomalies. Methods: Two pediatric dentists evaluated panoramic radiographs of 429 children aged 8–14 years with molar incisor hypomineralization (study group) and 437 children without molar incisor hypomineralization (control group) in terms of developmental dental anomalies. Twelve different developmental dental anomalies were categorized into four types: size (microdontia, macrodontia); position (ectopic eruption of maxillary permanent first molars, infraocclusion of primary molars); shape (fusion, gemination, dilaceration, taurodontism, peg-shaped maxillary lateral incisors); and number (hypodontia, oligodontia, hyperdontia) anomalies. Results: No significant difference was observed in the frequencies of developmental dental anomalies between the study and control groups in total, females, and males (p > 0.05). A statistically significant difference was found between the distribution of developmental size, position, shape, and number anomalies between the study and control groups (p = 0.024). The most common anomaly in both groups was hypodontia (6.3% and 5.9%, respectively). There was a significant difference between the study and control groups in terms of subtypes of shape anomaly in all children and females (p = 0.045 and p = 0.05, respectively). Conclusions: While a significant difference was observed between the distributions of types of developmental dental anomalies between individuals with and without molar incisor hypomineralization, there was no difference in terms of the frequency of developmental dental anomalies.Publication Open Access Assessment of dental fear in children with molar-incisor hypomineralization(2022-01-01) TUĞCU, NİHAN; DURMUŞ, BAŞAK; KARGÜL, BETÜL; SEZER B., Tuğcu N., Çalışkan C., DURMUŞ B., KARGÜL B.© 2022 Polish Dental AssociationIntroduction: Dental fear is a common unpleasant emotional response that occurs in situations related to dental treatment. Since children affected by molar-incisor hypomineralization (MIH) receive much more dental treatment than their healthy peers, these children may have more dental fear and behavioral problems. Objectives: The aim of the study was to assess the relation between the presence and severity of MIH and dental fear. Material and methods: Study group involved a sample of 127 children, aged between 8 and 12 years with MIH, showing a high-risk of caries, and 99 children were included into control group. In the wake of intra-oral examination according to the American Academy of Pediatric Dentistry guideline and DMFT/dmft indices, Children’s Fear Survey Schedule – Dental Subscale (CFSS-DS) was applied to each child. Mean value of independent groups for normally distributed data was compared using independent samples t-test. Spearman’s correlation was applied for correlations between DMFT/dmft scores and CFSS-DS scores. P-value of < 0.05 was considered statistically significant. Results: The final number of individuals affected by MIH in this study was 127 with approximately equal numbers for each age group. The mean CFSS-DS scores were 31.41 ± 10.73 for the MIH-group, and 31.60 ± 6.21 for the controls, respectively. The mean values did not differ significantly between children with and without MIH (p = 0.870). There were also no statistically significant differences in severe MIH (31.38 ± 10.93) compared with the control group (31.60 ± 6.21) (p = 0.890). Conclusions: The study’s findings revealed that there is no relation between the existence and severity of MIH and dental fear.Publication Metadata only Molar-İncisiv Hipomineralizasyonu olan çocuklarda Türk çocuk ağız sağlığı etki profili kısa formunun (COHIP-SF 19) doğrulaması(2023-07-06) TUĞCU, NİHAN; KARGÜL, BETÜL; DURMUŞ, BAŞAK; BEKİROĞLU, GÜLNAZ NURAL; Tuğcu N., Bekiroğlu G. N., Kargül B., Durmuş B.Publication Open Access Randomized clinical trial of heated high viscosity glass ionomer class ii restorations in deciduous molars: 12 months follow up(2022-06-01) EREN GİRAY, FİGEN; KARGÜL, BETÜL; YILMAZ, MÜESSER AHU; YILMAZ M. A., EREN GİRAY F., Ince E. B. T., TÜZÜNER T., AYKUT YETKİNER A., ERSİN N., KARGÜL B.Objective: New generation High Viscosity Glass Ionomer Cements (HVGICs) have enhanced physical and mechanical properties. By effectively closing the restoration margin, it ensures that the restorations will last longer. The aim of this study was to investigate the clinical performances of heat-cured versus non heated HVGIC in class II restorations of deciduous molars.Publication Open Access Assessment of the oral health status of children with chronic kidney disease(2023-01-01) KAYA, REMZİYE; YILDIZ, NURDAN; KARGÜL, BETÜL; ALPAY, HARİKA; SEZER B., KAYA R., Dokumacigil N. K., SIDDIKOĞLU D., Guven S., YILDIZ N., ALPAY H., KARGÜL B.Background There are various oral symptoms related to the disease and its management in individuals with chronic kidney disease (CKD). The aim of the study was to investigate the oral health status of children with diferent stages of CKD, kidney transplant recipients (KTR), and healthy children. Methods A total of seventy-one children diagnosed with CKD and ffty-two healthy children were included in the study. Each patient was examined for dental caries by the decayed-missing-flled-teeth (DMFT/dmft) index and the International Caries Detection and Assessment System (ICDAS-II), developmental defects of enamel (DDE) by the DDE index, and oral hygiene by the debris (DI), calculus (CI), and simplifed oral hygiene (OHI-S) indices. Results The median number of DMFT/dmft was 1.00 (interquartile range (IQR):1.00–4.00) in children with stage 1–3 CKD, 0.00 (IQR: 0.00–2.50) in stage 4–5 children, 0.00 (IQR: 1.00–3.00) in KTR, and 8.00 (IQR: 1.00–13.00) in healthy children. According to ICDAS-II categories, the percentage of children with severe caries was 53.8% in healthy children, while it was 44.4% in KTR, 25.9% in stage 1–3, and 11.4% in stage 4–5 children. While the percentage of children with DDE was 88.8% in KTR, 80% in stage 4–5, and 66.7% in stage 1–3 children, this rate was 44.2% in healthy children. The highest mean OHI-S score was observed in stage 4–5 children (2.10±1.08), followed by KTR (1.46±1.19), stage 1–3 (1.27±0.61), and healthy children (0.45±0.44), respectively. Conclusions Compared to healthy children, children with CKD had more debris accumulation, calculus formation, and more DDE but a lower severity of dental caries.Publication Metadata only Riboflavinin demineralize dentine uygulanmasının biomimetik remineralizasyon açısından optik koherens tomografi ile incelenmesi(2022-04-21) YILMAZ ATALI, PINAR; TÜRKMEN, CAFER; KARGÜL, BETÜL; Kükey P., Altuntaş E., Yılmaz Atalı P., Türkmen C., Kargül B.Investigation of Riboflavin as Biomimetic Mineralization on Demineralized Dentin by Optical Coherence TomographyPelin Kükey1, Ezgi Altuntaş1, Pınar Yılmaz Atalı1, Cafer Türkmen1, Betül Kargül21Marmara University, Faculty of Dentistry, Department of Restorative Dentistry, İstanbul, Turkey 2Marmara University, Faculty of Dentistry, Department of Pediatric Dentistry, İstanbul, TurkeyAim: Optical coherence tomography (OCT) has considerable potential as a non-invasive imaging technique for carious lesions as it eliminates the need for the removal of the superficial layer and eliminates radiation. The aim of this study was to assess the biomimetic remineralization capacity of Riboflavin for demineralized dentin samples using spectral-domain optical coherence tomography (SD-OCT).Materials and Methods: Twenty four dentin blocks were randomly divided into 6 groups as: 2% Riboflavin; Universal bonding agent (Optibond Universal, Kerr); Functional tricalcium phosphate (fTCP) (Clinpro TM 5000, 3M) ; Universal bonding agent+2% Riboflavin; fTCP + 2% Riboflavin; Remineralizing solution (Positive Control). The dentin samples were immersed in a demineralization solution maintained for 72 hours and remineralization agents were applied for 10 days. The optical depth of backscattered light of enamel was measured using Zeiss Cirrus HD SD-OCT 5000 (Carl Zeiss Meditec). SD-OCT analyzes were performed after demineralization and after remineralization procedures. The appropriate values that correspond to the visual boundary of dentin lesions were measured. Paired two-sample t-test was used to compare the application within the groups (p<0.05)Results: At the baseline (after demineralization), there was no statistically significant difference in the optical lesion depths of the dentin blocks in the six groups (p=0.487). The reflectivity and the optical lesion depth decreased after remineralization in all groups. A significant decrease in the depth of optical lesion on the dentin surfaces in all groups was observed following the remineralization (p<0.05) except adhesive application (p>0.05)Conclusion: Within the limitations of this study, the surface treatment with Riboflavin provided biomimetic dentin remineralization. Further investigations are needed on Riboflavin as a potential innovative bioactive material of dentine remineralization as minimal intervention which is an important concept in clinical restorative dentistry.Keywords: biomimetic mineralization, riboflavin, tri-calcium phosphate, optical coherence tomography (OCT)Publication Metadata only Farklı remineralizasyon ajanlarının yapay mine lezyonları üzerinde iki farklı kantitatif floresan sistemine göre etkisi(2023-07-07) ÖZSALİH BİLSEL, SEDA; KARGÜL, BETÜL; BEKİROĞLU, GÜLNAZ NURAL; YILMAZ, MÜESSER AHU; Özsalih Bilsel S., Kargül B., Doğan S., Bekiroğlu G. N., Yılmaz M. A.