Person: KARGÜL, BETÜL
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KARGÜL
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BETÜL
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Publication Open Access Association between work-related musculoskeletal symptoms and quality of life among dental students: a cross-sectional study(BMC, 2022-12) KARGÜL, BETÜL; Sezer, Berkant; Kartal, Sinan; Siddikoglu, Duygu; Kargul, BetulBackground Dental students are frequently affected by work-related musculoskeletal symptoms (WMSs) due to reasons such as working conditions, difficult education process and long work periods. The aim of the study was to investigate the frequency and anatomical distribution of WMSs, and its effect on the quality of life (QoL) in dental students. Methods Sociodemographic and health-related characteristics of one-hundred and five dental students were recorded. WMSs were scored by the participants with the Nordic Musculoskeletal Questionnaire. Then, participants were asked to evaluate their QoL by scoring the World Health Organization Quality of Life-Brief Form. Differences between independent groups for continuous variables were evaluated by Student's t-test and ANOVA as appropriate. Linear regression analysis was performed to determine the effect of demographic and health-related parameters in predicting the QoL subscales. Results The most common painful region in the last 12 months was the neck (66.7%). The body region with the most WMSs in the last 7 days was the upper back (43.8%). Physical health-related QoL of those with diagnosed musculoskeletal symptoms, and general health-related QoL of those using medicine due to any musculoskeletal symptoms were found to be statistically significantly lower (p = 0.018, p = 0.041, respectively). It was observed that the general and physical health, psychological well-being, and social relationship of the participants who reported the presence of neck pain in the last 7 days were statistically significantly lower (p = 0.003, p < 0.001, p = 0.004, p = 0.012; respectively). According to multiple regression analyses, pain occurrence in the body in the last 12 months and/or in the last 7 days had a negative impact on the participants' general and physical health, psychological well-being, social relationship, and environmental status and related QoL (p = 0.026, p = 0.047, p = 0.021, p = 0.001, p = 0.027, respectively). Conclusions The results of this study show that dental students' body regions, especially the neck and the back, are affected by WMSs. These negative changes observed in the body had a negative effect on the QoL of the dental students.Publication Metadata only The relation between laser fluorescence scores after caries removal and microtensile bond strength(2023-07-04) KANAR, ÖZLEM; TAĞTEKİN, DİLEK; KORKUT, BORA; KARGÜL, BETÜL; KANAR Ö., TAĞTEKİN D., KORKUT B., YANIKOĞLU F., KARGÜL B.Publication Open Access Effect of Remineralization Agents on Molar-Incisor Hypomineralization-Affected Incisors: A Randomized Controlled Clinical Trial(2022-01-01) KARGÜL, BETÜL; SEZER B., KARGÜL B.Objective: The objective of this study was to evaluate the remineralization effect of two different mineral containing agents on white/creamy and yellow/brown demarcated opacities in incisors in children with molar-incisor hypomineralization (MIH) by using laser fluoresence (LF). Study Design: Fifty-three children (n=401 lesions) with MIH were randomly divided into three groups: (1)calcium glycerophosphate (CaGP), (2)casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) and, (3)control (1450 ppm fluoride toothpaste). Remineralization was evaluated by means of LF, at baseline, after one and threemonths. Anova Test for Repeated Measurements in intra-group comparisons in evaluating the effectiveness of remineralization agents. One-way Variance Analysis (ANOVA) and Tukey-Kramer Multiple Comparison test were used in the comparisons between groups and, Student Newman Keuls Multpile Comparison Test was used to determine the differences between the measurement averages in case of p<0.05. Results: There was a significant improvement in MIH-lesions over time in all groups (p<0.001), with no differences between groups. The highest percentage of change was observed in CPP-ACFP in lesions LF≤20 scores and the mean percentage of change LF>20 scores, the highest percentage changes in CaGP. There was no significant difference between the groups over the time for all the used outcome measures (p>0.05). Conclusion: The additional use of both mineral containing agents in MIH-affected teeth improved these hypomineralized lesions with mineral deposition. Even if both agents could be used in the hypomineralized teeth with demarcated opacities, future studies are recommended the long-term effect of these mineral containing agents with longer observation and a larger sample size. Keywords: Molar incisor hypomineralization, Calcium glycerophosphate, Casein phosphopeptideamorphous calcium phosphate nanocomplex, Tooth remineralization.Publication Metadata only Effect of biomimetic mineralization on demineralized dentin: a SEM/EDS analysis(2021-09-16) KARGÜL, BETÜL; TÜRKMEN, CAFER; atalı p., TÜRKMEN C., kukey p., KARGÜL B.Publication Metadata only The effect of a single application of different fluoride varnishes on enamel subsurface lesions in vitro(2022-04-01) ŞEN YAVUZ, BETÜL; YILMAZ, MÜESSER AHU; OKTAY, NİHAL ŞEHKAR; KARGÜL, BETÜL; Yildiz P. K., ŞEN YAVUZ B., YILMAZ M. A., OKTAY N. Ş., KARGÜL B.This in vitro study aimed to evaluate the therapeutic effect of different fluoride ion (F) varnish formulations for controlling the carious development of enamel subsurface lesions and the F release into artificial saliva for 2 hr, 24 hr, 48 hr, and 7 days. Artificial enamel carious lesions were created and divided into 6 groups (5 varnish groups and a control group). Varnishes were applied to enamel specimens and then the specimens were incubated in artificial saliva, with the artificial saliva replenished daily. Varnish was removed and lesions were remineralized in artificial saliva for 24 hr. Surface microhardness was measured three times: (i) initially, (ii) after creating the artificial enamel lesions, and (iii) after applying the varnishes. The F release was analyzed after 2 hr, 24 hr, 48 hr, and 7 days of exposure using an ion-selective electrode. Data were analyzed using a One-way Analysis of Variance with the Tukey-Kramer Multiple Comparisons test and the Kruskal-Wallis test with the Dunns Multiple Comparisons test. The highest percentage surface microhardness recovery was found for the treatment with the MI Varnish. According to the percentage surface microhardness recovery results, a statistically significant difference was found between the varnishes and the control group (p < 0.05 and < 0.001). All varnishes released measurable levels of fluoride ions. However, the release of F was the highest in the MI Varnish group (p < 0.01). Duraphat, Enamel Pro Varnish, and MI Varnish released the most F into artificial saliva. Calcium phosphate-based F varnishes improve the capacity of the enamel surface re -hardening. CPP containing F varnish had the highest release of F as compared to the other F releasing varnishes. Further in vivo investigations are also required to prove the clinical applications of the different ingredients containing varnishes.Publication Open Access Caries Preventive Effects of Theobromine Containing Toothpaste on Early Childhood Caries: Preliminary Results(UNIV ZAGREB, SCH DENTAL MEDICINE, 2021-03-15) KARGÜL, BETÜL; Durhan, Muesser Ahu; Bisel, Seda Ozsalih; Gokkaya, Berna; Yildiz, Pinar Kulan; Kargul, BetulObjective: Enamel remineralizing effects of theobromine have received much attention from the clinicians. The aim of this study was to investigate the caries preventive effect of theobromine containing toothpaste on children with early childhood caries (ECC). Materials & Methods: Salivary pH, buffering capacity and frequency of Streptococcus mutans (SM) levels were measured. Each child was assigned either fluoridated or theobromine containing toothpaste. The changes were analyzed using Laser Fluorescence system. Statistical analyses were performed. Results: We included 13 children (mean age 4.25) with 145 teeth in the fluoridated toothpaste (Colgate Kids toothpaste) group; 13 children (mean age 4.46) with 115 teeth in theobromine containing toothpaste (Theodent (TM) Kids toothpaste) group. Both toothpastes demonstrated enamel remineralization and were effective in increasing the buffering capacity and pH (p < 0.05). A statistically significant decrease in S. mutans levels was found in both toothpaste groups (p<0.05). Conclusion: Both toothpaste group showed a statistically significant amount of enamel remineralization. Since theobromine had the added benefits of increasing the salivary pH and decreasing the S.mutans levels, theobromine containing toothpastes can be considered effective agents in remineralizing white spot lesions and can be used in prevention of early enamel lesions.Publication Metadata only Do ginger extract, natural honey and bitter chocolate remineralize enamel surface as fluoride toothpastes? an in-vitro study(Wolters Kluwer Medknow Publications, 2021) KARGÜL, BETÜL; Celik Z.C., Yavlal G.O., Yanikoglu F., Kargul B., Tagtekin D., Stookey G.K., Peker S., Hayran O.Background: In recent literatures, much attention has been given to natural products for their health benefits. Aims: In this study, the objective was to measure the efficacy of the ginger-honey-chocolate mixture as the remineralization effect has been shown in the literature previously and to evaluate the individual contributions of this mixture; ginger, natural honey, bitter chocolate separately on remineralization of initial enamel caries lesion. Materials and Methods: All specimens were divided into eight groups as: Ginger (Arifoglu®, Turkey) in powder form, (n = 8); Ginger-Honey-Chocolate (n = 8); Natural honey (Balparmak Plateau Blossom Honey®, Turkey) (n = 9); Bitter chocolate (Nestlé®, Switzerland) (n = 8); MI Paste (GC, Japan) (n = 8); Paradontax (Sensodyne, Glaxosmithklein, USA) (n = 9); Pronamel (Sensodyne, Glaxosmithklein, USA) (n = 9); Control (n = 9) groups. Samples were carried out five pH cycles along 7 days at 37°C for each group. During pH cycling, blocks were put in a demineralization (6 h) and a remineralization solution (18 h). The treatment consisted of 1 min. interaction of enamel surfaces with agent/deionized slurries (1:3 w/w) on a daily basis. The surface microhardness (SMH) was determined before and after pH cycling with a Digital Micro-Vickers Hardness Tester (Wilson Wolpert; Europe BV, 401 MVD, Netherlands). Mineral changes were determined by using FluoreCam® and recovery values were calculated as SMHR% and FΔ%, respectively. Results: All groups showed an enhanced remineralization. There was no significant difference in terms of FΔ% (F = 1.223, P = 0.304) and SMHR% (F = 0.709, P = 0.664) between all groups. Conclusion: The herbals (ginger, honey, and bitter chocolate) examined in this study gave promising results with a high remineralization potential. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.Publication Metadata only Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study(2023-01-01) KAYA, REMZİYE; ALPAY, HARİKA; KARGÜL, BETÜL; SEZER B., Kodaman Dokumacıgil N., KAYA R., Güven S., Türkkan Ö. N., Çiçek N., ALPAY H., KARGÜL B.Objectives: The aim of this study was to investigate the association between serum biomarkers and oral health parameters in children with chronic kidney disease (CKD). Materials and methods: Serum hemoglobin, blood urea nitrogen, serum creatinine, calcium, parathormone, magnesium, and phosphorus levels were measured in 62 children with CKD aged between 4 and 17 years. Intraoral examinations of the patients were performed by two different pediatric dentists. Dental caries was assessed using the decayed-missing-filled-teeth (DMFT/dmft) indexes, and oral hygiene was assessed using the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indexes. Spearman’s rho coefficient and generalized linear modeling were used to examine the association between serum biomarkers and oral health parameters. Results: The results of the study showed that there were negative and statistically significant correlations between serum hemoglobin and creatinine levels and dmft scores in pediatric patients with CKD (p = 0.021 and p = 0.019, respectively). Furthermore, blood urea nitrogen levels and DI and OHI-S scores (p = 0.047 and p = 0.050, respectively); serum creatinine levels and DI, CI, and OHI-S scores (p = 0.005, p = 0.047, p = 0.043, respectively); and parathormone levels and CI and OHI-S scores (p = 0.001 and p = 0.017, respectively) were found to be positively and statistically significantly related. Conclusions: There are associations between various serum biomarker levels and dental caries and oral hygiene parameters in pediatric patients with CKD. Clinical relevance: The impact of changes in serum biomarkers on oral and dental health is important for dentists’ and medical professionals\" approaches to patients\" oral and systemic health.Publication Metadata only Evaluation of different remineralization agents in the treatment of natural caries-affected dentin in permanent teeth(2023-01-01) KARGÜL, BETÜL; Turkay E. Y., KARGÜL B., Aydinoglu A. K., HAZAR A. B.BACKGROUND: In the preventive treatment protocol, providing remineralization of the tissue in demineralized dentin caries is an important step. OBJECTIVE: In this in vitro study, the effectiveness of remineralization agents in natural caries-affected dentin (NCAD) were investigated. METHODS: Forty caries slices were prepared from permanent molar dentin with International Caries Detection and Assessment System (ICDAS 2) (Code 3). The interventions with 8 days pH cycling were as follows: Deionized water (DW); 5% Sodium Fluoride (5% NaF) Varnish; Casein Phosphopeptide-Amorphous Calcium Fluoride Phosphate (CPP-ACFP); Calcium Glyserophosphate (CaGP) + Magnesium (Mg) + Xylitol. DIAGNOdent (Laser Fluorescence, LF), Surface Microhardness (SMH), and X-ray Fluorescence (XRF) Spectroscopy measurements were calculated before and after pH cycling. RESULTS: LF values decreased between 5% NaF, CCP-ACFP and CaGP. NCAD treated with 5% NaF, CaGP and CCP-ACFP exhibited statistically higher hardness compared to the control group. After 5% NaF application, SMH values were significantly higher than the others. There was no statistically significant difference between baseline and after pH cycling hardness of the control group. After cycling, XRF showed that Ca and P concentrations were increased in all groups. CONCLUSION: The application of agents used in the study could be recommended and promoted as a treatment option of caries dentin for conventional management of caries.Publication Open Access Assessment of potential risk factors associated with early childhood caries in a subpopulation of children from Thrace region of Turkey(2021-01-01) KARGÜL, BETÜL; GÜNER ONUR Ş., KARGÜL B.Abstract Introduction: Early childhood caries (ECC) is considered a global health concern due to its high prevalence and effect on the overall health of children. Aim: The present study aimed to investigate prevalence of ECC and associated risk factors in a Turkish subpopulation of children. Materials and methods: Five hundred forty-two (299 boys, 243 girls) children were enrolled in this study. Caries experience on primary teeth was measured using decayed or filled teeth (dft) index and the presence of caries was diagnosed if dft >0. A structured questionnaire was employed to mothers through interview. Results: ECC was significantly associated with increased age (OR=1.032; 95% CI, 1.018–1.047; p<0.001), low level of family income (OR=2.91; 95% CI, 1.567–5.404; p=0.001), low educational level of mother (OR=2.602; 95% CI, 1.509–4.485), night-time frequent breastfeeding (OR=1.695; CI, 1.07–2.685; p=0.024) and bottle feeding with sugary beverages (OR=1.689; CI, 1.002–2.847; p=0.049). First dental visit age (OR=1.482; 95% CI, 1.254–1.753; p<0.001) and initial age of tooth brushing (OR=2.062; 95% CI, 1.324–3.209; p=0.001) were found to be protective against ECC development. Conclusions: The current study highlights potential factors that are commonly associated with the risk of developing ECC. From the perspective of public health, a better understanding of socioeconomic, environmental, maternal and behavioural risks factors for ECC will aid improving maternal and child-based health promotion and preventive programmes.