Person: GÜLÇEBİ İDRİZ OĞLU, MEDİNE
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GÜLÇEBİ İDRİZ OĞLU
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MEDİNE
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Publication Metadata only EFFECTS OF KINDLING STIMULATIONS ON TYROSINE HYDROXYLASE IMMUNOREACTIVITY IN SUBSTANTIA NIGRA PARS RETICULATA OF GAERS AND WISTAR RATS(2013-06-27) GÜLÇEBİ İDRİZ OĞLU, MEDİNE; KARAMAHMUTOĞLU, TUĞBA; ONAT, FİLİZ; GÜLÇEBİ İDRİZ OĞLU M., AKMAN Ö., ÇARÇAK YILMAZ N., KARAMAHMUTOĞLU T., ONAT F.Publication Metadata only Electroencephalographic and behavioral effects of intracerebroventricular injection of grayanotoxin in adult Wistar rats(2011-08-28) KARAMAHMUTOĞLU, TUĞBA; GÜLÇEBİ İDRİZ OĞLU, MEDİNE; ONAT, FİLİZ; HALAÇ H. M. , TEMİZ G., KURU P., TORUN M., İSKENDER E., KARAMAHMUTOĞLU T., GÜLÇEBİ İDRİZ OĞLU M., ONAT F.Publication Metadata only EFFECTS OF KINDLING STIMULATIONS ON PARVALBUMIN IMMUNOREACTIVITY IN SUBSTANTIA NIGRA PARS RETICULATA OF GAERS AND WISTAR RATS(2014-07-03) GÜLÇEBİ İDRİZ OĞLU, MEDİNE; KARAMAHMUTOĞLU, TUĞBA; ONAT, FİLİZ; AKMAN Ö., GÜLÇEBİ İDRİZ OĞLU M., KARAMAHMUTOĞLU T., ONAT F.Publication Metadata only Ultrastructural GABA immunocytochemistry in the mossy fiber terminals of Wistar and genetic absence epileptic rats receiving amygdaloid kindling stimulations(ELSEVIER, 2011) AKAKIN, DİLEK; Akakin, Dilek; Sirvanci, Serap; Gurbanova, Ayten; Aker, Rezzan; Onat, Filiz; San, TangulThe existence of absence epilepsy and temporal lobe epilepsy in the same patient is not common in clinical practice. The reason why both types of seizures are rarely seen in the same patient is not well understood. Therefore, we aimed to investigate kindling in a well known model of human absence epilepsy, genetic absence epilepsy rats from Strasbourg (GAERS). In the present study, we analyzed whether the GABA content of GAERS that received kindling stimulations was altered in the hippocampal mossy fiber terminals compared to non-epileptic control (NEC) Wistar rats. For this purpose, we used an immunocytochemical technique at the ultrastructural level. Ultrathin sections were immunolabeled with anti-GABA antibody and transmission electron microscopy was used for the ultrastructural examination. The number of gold particles per nerve terminal was counted and the area of the nerve terminal was determined using NIH image analysis program. The GABA density was found to be higher in sham-operated GAERS than sham-operated Wistar rats. The density was increased in kindling Wistar group compared to sham-operated Wistar and kindling GAERS groups. No statistical difference was observed between sham-operated GAERS and kindling GAERS groups. The increase in GABA levels in stimulated Wistar rats may be a result of a protective mechanism. Furthermore, there may be strain differences between Wistar rats and GAERS and our findings addressing different epileptogenesis mechanisms in these strains might be a basis for future experimental studies. (C) 2010 Elsevier B.V. All rights reserved.Publication Open Access Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats(KARE PUBL, 2016) ONAT, FİLİZ; Gulcebi, Medine; Akman, Ozlem; Carcak, Nihan; Karamahmutoglu, Tugba; Onat, FilizOBJECTIVE: Nonconvulsive absence epilepsy and convulsive epilepsy seizures are rarely seen in the same patient. It has been demonstrated that there is a resistance to development of convulsive seizures in genetic absence epilepsy models. The present study investigated glutamic acid decarboxylase (GAD) immunoreactivity in the brain region related to the interaction of these two seizure types, namely substantia nigra pars reticulata (SNR) subregions, SNRantenor and SNRpostenor. METHODS: Nonepileptic adult male Wistar rats and Genetic Absence Epilepsy Rats from Strasbourg (GAERS) were used. Experimental groups of Wistar and GAERS were electrically stimulated for kindling model to induce convulsive epileptic seizures. An electrical stimulation cannula was stereotaxically implanted to the basolateral amygdala and recording electrodes were placed on the cortex. Sagittal sections of SNR were used to evaluate immunohistochemical reaction. Sections were incubated with anti-GAD67 antibody. Densitometric analysis of GAD67 immunoreactive neurons was performed using photographs of stained sections. One-way analysis of variance and post hoc Bonferroni test were used for statistical analysis of the data. RESULTS: There was no difference in GAD67 immunoreactivity of SNR subregions of control Wistar and control GAERS. An increase in GAD67 immunoreactivity was detected in SNRposterior subregion of stimulated Wistar rats, whereas there was a decrease in GAD67 immunoreactivity in SNRposterior of stimulated GAERS. The difference in GAD67 immunoreactivity between these two groups was statistically significant. CONCLUSION: Level of synthetized gamma-aminobutyric acid in SNRposterior subregion plays an important role in the interaction of nonconvulsive absence epilepsy seizures and convulsive epilepsy seizures.Publication Open Access Does Feeding Behaviour of Genetic Absence Epilepsy Rats Differ from Control Wistar Rats(2012-09-30) GÜLÇEBİ İDRİZ OĞLU, MEDİNE; KARAMAHMUTOĞLU, TUĞBA; ONAT, FİLİZ; GÜLÇEBİ İDRİZ OĞLU M., KETENCİ S., KARAMAHMUTOĞLU T., AKIN D., ONAT F.