Person: KURU, LEYLA
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KURU
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LEYLA
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Publication Metadata only Oral squamous cell papilloma: a case report(AVES PRESS LTD, 2015) ÖZTÜRK ÖZENER, HAFİZE; Ozener, Hafize Ozturk; Kuru, Leyla; Kuru, BaharOral squamous cell papilloma (OSCP) is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass. OSCP is usually associated with human papilloma virus. Although any surface of the oral cavity can be affected, the sites of predilection for localization of the lesions include the tongue, lip and soft palate. In this report, treatment and histological findings of a local gingival enlargement at the vestibular side of the upper right central tooth of a 10 year-old systemically healthy girl are presented. The lesion was asymptomatic and had shown a slow growth. Solitary, exophytic lesion was clinically soft, pink-white in color and appeared as cauliflower. Dental and periodontal tissues were radiographically normal. One month after scaling and root planing, under local anesthesia the lesion was excised and this was followed by the use of Nd: YAG laser (1064 nm, 20 Hz, 3 W) to control bleeding, minimize pain and scarring in post-operative period, and provide sterilization. Macroscopic examination revealed that the lesion was 1.1x0.5x0.2 cm(3) in size, yellow in colour and had a rough surface, while histological examination showed multi-layer connective tissue underlying the squamous epithelium, numerous rete pegs and spinous cell proliferation at the papillary and OSCP was diagnosed. There was no evidence of viral cytopathic effect or malignancy of the lesion. No recurrence was observed during the 4-year follow-up period..Publication Open Access Periodontal treatment approach for dihydropyridine induced gingival overgrowth with or without drug substitution(2022-06-01) ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; Eroğlu O., YETİŞ E., ÖZTÜRK H., KURU L.Objectives: The aim of this study is to evaluate clinical effectiveness of nonsurgical periodontal treatment (NSPT) in patients with drug induced gingival overgrowth (DIGO) with or without drug substitution in comparison with patients presenting inflammatory gingival overgrowth (GO). Material and Methods: A total of 17 patients with generalized GO were included in this clinical trial. Based on the medical physicians consultation, DIGO patients who continued using dihydropyridine were allocated to the Group 1 (n=6), whereas patients whose drug substitution was carried out were allocated to the Group 2 (n=5). Group 3 (n=6) subjects had inflammatory GO. All study groups received NSPT for 4 sessions. At baseline and 6 weeks after NSPT, plaque index, gingival index, bleeding on probing (BOP), probing depth (PD) and, plaster model and photographic GO scores were measured. Results: NSPT resulted in significant decreases in periodontal clinical parameters in all groups (p<0.05). Intergroup comparisons of baseline measurements revealed no statistically significant differences (p>0.05) except PD value which was higher in the Group 1 compared to the Group 2 (p<0.05). Comparisons of post-NSPT data among groups exhibited statistically significant difference only between Groups 1 and 2 in the model and photographic GO scores (p<0.05). Conclusions: After the 6-week evaluation period, NSPT was found to be an effective method in reducing the severity of inflammation and size of overgrown gingival tissues in patients with DIGO and inflamatory GO. Substitution of drug causing GO provided further contribution to NSPT regarding the size of overgrown gingiva in the patients with DIGO.Publication Open Access Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects(HINDAWI LTD, 2018-06-28) ÖZBEYLİ, DİLEK; Agrali, Omer B.; Yildirim, Selin; Ozener, Hafize O.; Kose, Kemal N.; Ozbeyli, Dilek; Soluk-Tekkesin, Merva; Kuru, LeylaHyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals. The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G). Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included. Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats. In the same rats, the other defect was treated with HA matrix alone. One of the 2 defects formed in other 8 rats was treated with HA + G and the other with HA + M. One of the 2 defects formed in the remaining 8 rats was treated wilh G+M and the other with HA+G+M. The animals were sacrificed at 4 weeks. Histologic, histomorphometric, and immunohistochemical analyses were performed. Both HA matrix alone and its combinalions with G and M supported new bone formation (NBF). However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P < 0.00l). Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them. Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.Publication Open Access Assessment of reliability of three indices measuring gingival overgrowth procjena pouzdanosti triju indeksa za mjerenje hiperplazije gingive(2023-06-01) ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; Alkateb A. S., ÖZTÜRK ÖZENER H., KURU L.Objectives: Numerous indices have been used to grade the severity of gingival overgrowth which led to suspicion regarding the results concerning its prevalence and pathogenicity. The aim of this study was to assess the concordance of three different gingival overgrowth indices, which were used wide-ly in previous studies, and check their reliability and reproducibility. Material and Methods: A total of 30 full-mouth plaster casts and 90 intra-oral photographs collected from 30 patients diagnosed with gingival overgrowth were included in our study. Three trained examiners performed measurements twice on plaster casts using gingival hyperplasia index (A index) and hyperplastic index (B index). In-traoral photographs were assessed also twice using (C index). Results: Concordance of intra-exam-iner and inter-examiner reliability of the recorded measurements was carried out for each index using weighted kappa (K), with a confidence interval of 95%. The A index revealed intra-examiner total kappa values between 0.724-0.876 for horizontal measurement and 0.512-0.823 for vertical mea-surement, and inter-examiner total kappa values between 0.255-0.626 horizontally and 0.235-0.279 vertically. The B index presented intra-examiner total kappa values between 0.587-0.868 horizontally and 0.653-0.855 vertically; and inter-examiner total kappa values between 0.393-0.595 and 0.372-0.635 for horizontal and vertical measurements, respectively. The C index achieved the highest intra-examiner concordance with total kappa values between 0.758-0.855 and inter-examiner total kappa values between 0.716-0.804. Conclusions: The C index evaluated through intraoral photographs is considered the most reliable and applicable method to be utilized. The C index is suggested to be used in large scale populations with its definite detailed criteria.Publication Metadata only Evaluation of Patient's Perceptions, Healing, and Reattachment After Conventional and Diode Laser Frenectomy: A Three-Arm Randomized Clinical Trial(MARY ANN LIEBERT, INC, 2020) ÖZTÜRK ÖZENER, HAFİZE; Sezgin, Gamze; Ozener, Hafize Ozturk; Meseli, Suleyman Emre; Kuru, LeylaObjective:The aim of this study is to compare the conventional and diode laser techniques in terms of patient's perceptions, epithelization, reattachment, and periodontal clinical parameters in the treatment of abnormal papillary frenum. Materials and methods:Forty-eight patients with abnormal papillary frenum were enrolled in the study. Patients were randomly assigned into three groups; conventional frenectomy operation (C group), diode laser-assisted frenectomy (L group), and diode laser-assisted frenectomy with conventional horizontal incision on the periosteum (L + P group). Post-operative pain, discomfort in speaking, and chewing scores were assessed with visual analogue scale (VAS) at post-operative 3rd hour and on days 1, 7, 14, 21, and 45. Epithelialization process of the wound surface was evaluated by hydrogen peroxide solution applied to the wound on days 7, 14, 21, and 45 following operations. The distance between the frenum attachment point and mucogingival junction (FMGJ) was recorded at baseline, post-operative 45th day, and 6th month to assess the reattachment of the frenum. Plaque index, gingival index, bleeding on probing, and probing depth were recorded at baseline and post-operative 7th, 14th, 21(st), and 45th days. Results:On the 1st and 7th day after operation, VAS pain score in the C group was significantly higher than in the L and L + P groups (p < 0.017). Difficulty in speaking and chewing scores were significantly lower in the L and L + P groups compared to the C group at post-operative 3rd hour and 7th day (p < 0.017). The FMGJ and epithelization period demonstrated no difference among the groups at any time point (p > 0.05). Conclusions:Our results suggest that diode laser provides better post-operative patient's perceptions than the conventional technique in frenectomy operation. In addition, both conventional and laser-assisted frenectomy surgeries prevent the frenum reattachment regardless of periosteal horizontal incision.Publication Metadata only Rat kalvaryal defektlerinde D3 vitamininin yönlendirilmiş kemik rejenerasyonu üzerine etkisinin değerlendirilmesi(2022-11-06) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.Amaç: Bu çalışmada oral yolla verilen D3 vitamininin ratlarda yönlendirilmiş kemik rejenerasyonuna etkisinin histolojik olarak değerlendirilmesi amaçlandı. Gereç-Yöntem: Çalışma 12 adet erişkin erkek SpragueDawley cinsi rat üzerinde gerçekleştirildi. Tüm ratların kalvaryal kemiklerinde 5 mm çapında oluşturulan defektlere sığır kaynaklı kemik grefti (BioOss®) ile birlikte kolajen esaslı rezorbe olabilen membran (BioGide®) uygulandı. Cerrahi sonrası ratlar rastgele iki gruba ayrıldı; birinci gruba (Kontrol Grubu) distile su, ikinci gruba (Test Grubu) ise 2 µg /kg D3 vitamini günde 1 kez olmak üzere gavajla 8 hafta boyunca verildi. 8 haftanın sonunda ratlar sakrifiye edildi. Hematoksilen-Eozin ile boyanan örnekler histolojik olarak incelendi. ImageJ yazılım programı kullanılarak yeni kemik, rezidüel greft ve fibröz doku alanları hesaplandı. Verilerin istatistiksel analizleri GraphPad Prism programında değerlendirildi. İstatistiksel anlamlılık p<0,05 olarak kabul edildi. Bulgular: Yeni kemik alan yüzdesinin test grubunda (%43,75) kontrol grubundan (%28,35) istatistiksel olarak anlamlı yüksek olduğu tespit edildi (p<0,05). Rezidüel greft alanı, test grubunda 0,56 ±0,21 mm2 iken kontrol grubunda 0,89±0,17 mm2 olarak saptandı (p<0,05). Fibröz doku alanının, test grubu (1,00±0,27 mm2) ile kontrol grubunda (1,10±0,23 mm2) benzer olduğu gözlendi (p>0,05). Sonuç: Bu çalışmanın sonuçları, yönlendirilmiş kemik rejenerasyonunu takiben oral yolla kullanılan D3 vitamininin ratların kritik boyuttaki kalvaryal defektlerinde yeni kemik dokusu oluşumunu artırdığını göstermiştir.Publication Open Access Proteomic analysis in nifedipine induced gingival overgrowth: A pilot study(2022-12-01) YARAT, AYŞEN; ÖZTÜRK ÖZENER, HAFİZE; KURU, LEYLA; YETİŞ E., YARAT A., Eroğlu O., ÖZTÜRK H., KURU L.Objective: The aims of the present study were to investigate the proteomic profile of nifedipine induced overgrown gingiva and compare with non-overgrown gingival tissues obtained from the same patients. Methods: Seven subjects under nifedipine medication for at least 6 months and diagnosed as nifedipine induced gingival overgrowth (NIGO) participated in the study. Periodontal clinical parameters were recorded. Gingival tissue samples were harvested from overgrown (GO+ Group, n=7) and non-overgrown regions (GO- Group, n=7) of the same patients. Proteomics was performed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technique. The identified proteins were further classified according to their molecular functions, biological processes and cellular component distribution for functional gene ontology analysis using a web-based bioinformatics tool. Mann Whitney-U and ANOVA tests were performed to compare clinical parameters and identified proteins with proteomics, respectively. Results: Bleeding on probing and gingival overgrowth index of the GO+ group were statistically significantly higher than the GO- group (p<0.05, p<0.01, respectively). A total of 143 proteins were identified in 14 gingival tissue samples using proteomics. Among the proteins identified, 79 of them were detected in higher quantities in the GO+ group (p<0.05) whereas remaining 64 were found higher in the GO- group (p<0.05). The analysis of functional gene ontology demonstrated that certain proteins exhibit roles in either stimulatory or inhibitory processes including cell proliferation, growth and apoptosis. Conclusion: The proteomic profiles of overgrown and non-overgrown gingiva suggest that the identified proteins expressed at different levels in both groups may contribute to the pathogenesis and progression of NIGO.Publication Metadata only Clinical Efficacy of Conventional and Diode Laser-Assisted Frenectomy in Patients with Different Abnormal Frenulum Insertions: A Retrospective Study(MARY ANN LIEBERT, INC, 2020) ÖZTÜRK ÖZENER, HAFİZE; Ozturk Ozener, Hafize; Meseli, Suleyman Emre; Sezgin, Gamze; Kuru, LeylaObjective:This retrospective study aimed to assess the recurrence of frenulum attachment and clinical parameters following conventional and diode laser-assisted frenectomy in patients with abnormal frenulum insertions. Material and methods:The records of 429 patients who underwent maxillary labial frenectomy between 2016 and 2018 were screened. A total of 70 records were included and evaluated based on gender, age, frenulum type, presence of diastema, periodontal disease, and surgical technique. Plaque index (PI), gingival index (GI), and probing depth (PD) were evaluated at baseline and 6 weeks postoperatively. Recurrence was determined by assessing the alteration in the distance from the frenulum attachment to the mucogingival junction (FMGJ) at baseline, 6 weeks, and 12 months. Results:Out of 70 patients (female/male 47/23; age 35.24 +/- 11.69 years), 32.9% presented gingival, 38.6% papillary, and 28.6% papilla-penetrating frenulum attachments. Clinical parameters and mean FMGJ values between the conventional (n = 36) and diode laser (n = 34) groups demonstrated no differences at baseline (p > 0.05). PI and GI were significantly higher in the conventional group (p < 0.001), whereas PD was similar (p > 0.05) at 6 weeks. No recurrence was observed in any of the patients at the sixth week. Moreover, 31 participants in the conventional group and 33 participants in the diode-laser group, a total of 64 patients (91.43%), did not present recurrence after 12 months. Conclusions:Within the limits of the study, considering the absence of recurrence in all types of abnormal frenulum insertions in both treatment groups, it was concluded that the diode laser could be used effectively as an alternative to the conventional frenectomy technique.Publication Open Access Single nucleotide polymorphisms in IL-1A RS1800587, IL-1B RS1143634 and vitamin D receptor rs731236 in stage III grade B/C periodontitis(2022-06-01) ÖZTÜRK ÖZENER, HAFİZE; ASLAN, BEGÜM; AĞRALI, ÖMER BİRKAN; ULUCAN, KORKUT; YILDIRIM, HATİCE SELİN; KURU, LEYLA; Ozener H., ASLAN B., Eken B. F., AĞRALI Ö. B., Yildrim H. S., Altunok E. C., ULUCAN K., KURU L.The purpose of the study is to determine the prevalence of interleukin (IL)-1A (rs1800587), IL-1B (rs1143634) and vitamin D receptor (VDR) (TaqI, rs731236) gene polymorphisms in the Turkish population and their association with Stage III Grade B/C periodontitis. Systemically and periodontally healthy individuals (N = 100) and Stage III Grade B/C periodontitis patients (N=100) based on clinical and radiographic examination were included in this research. Clinical attachment level, probing depth, bleeding on probing, plaque and gingival indices of the subjects were measured. Genotyping of IL-1A (rs1800587), IL-1B (rs1143634) and VDR (rs731236) polymorphisms was conducted by Real Time PCR. Allelic and genotypic distributions of IL-1A (rs1800587) gene polymorphism were not associated with periodontitis (p > 0.05). In IL-1B (rs1143634) gene polymorphism, the C allele was detected more frequently in healthy individuals compared with the periodontitis patients (p=0.045). CC genotype and C allele in VDR (rs731236) gene polymorphism was higher in periodontitis patients (p=0.031, p=0.034, respectively). In comparison with Grade B periodontitis patients and healthy subjects, CC genotype and C allele were observed more frequently in the Grade B periodontitis in terms of alleles (C/T) and genotypes for VDR (rs731236) polymorphism (p=0.024, p=0.008, respectively). This study presents that the VDR (rs731236) polymorphism are associated with enhanced susceptibility to Stage III periodontitis in the Turkish population. Furthermore, VDR (rs731236) polymorphism may be used as an identification criteria to discriminate Grade B and Grade C in Stage III periodontitis.