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TOKUÇ, AYŞE GÜLNUR

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TOKUÇ

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AYŞE GÜLNUR

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2017 - 201912020 - 20222
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Subject: cancer ×

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    Post-traumatic stress disorder in mothers of children who have undergone cancer surgery
    (WILEY, 2017) TOKUÇ, AYŞE GÜLNUR; Cerit, Kivilcim Karadeniz; Cerit, Cem; Nart, Omer; Eker, Nursah; Kiyan, Gursu; Dagli, Tolga; Ekingen, Gulsen; Tokuc, Gulnur; Karaca, Omer; Corapcioglu, Funda
    BackgroundThe aim of this study was to investigate the rate of post-traumatic stress disorder (PTSD) and associated risk factors among mothers of children who underwent cancer surgery. MethodThis cross-sectional, multi-center study included a total of 60 mothers whose children underwent major thoraco-abdominal surgery and were under follow up in the outpatient setting between February 2016 and May 2016. Clinical Data Form, Hospital Anxiety and Depression Scale (HADS), and Clinician-Administered PTSD scale were used. ResultsOf all participants, 13 (21.7%) were diagnosed with PTSD. These mothers had shorter duration of marriage, longer duration of hospital stay after surgery, and higher HADS scores, compared with the others without PTSD. Thoughts of guilt such as I am being punished or tested were more frequent in mothers with PTSD. Insomnia, irritability, concentration problems, and psychological reactivity were the most common symptoms. ConclusionPost-traumatic stress disorder is a severe disorder that may worsen the daily functioning of mothers and may also have an unfavorable effect on child. It is therefore of utmost importance for clinicians to recognize PTSD and the associated risk factors in order to guide these parents.
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    Malignancy and lymphoid proliferation in primary immune deficiencies; hard to define, hard to treat
    (WILEY, 2020) KOÇ, AHMET; Kiykim, Ayca; Eker, Nursah; Surekli, Ozlem; Nain, Ercan; Kasap, Nurhan; Akturk, Hacer; Dogru, Omer; Canbolat, Aylin; Somer, Ayper; Koc, Ahmet; Tokuc, Gulnur; Bozkurt, Suheyla; Turkoz, Kemal; Karakoc-Aydiner, Elif; Ozen, Ahmet; Baris, Safa
    Background Regarding the difficulties in recognition and management of the malignancies in primary immune deficiencies (PIDs), we aimed to present the types, risk factors, treatment options, and prognosis of the cancers in this specific group. Methods Seventeen patients with PID who developed malignancies or malignant-like diseases were evaluated for demographics, clinical features, treatment, toxicity, and prognosis. Results The median age of malignancy was 12.2 years (range, 2.2-26). Lymphoma was the most frequent malignancy (n = 7), followed by adenocarcinoma (n = 3), squamous cell carcinoma (n = 2), cholangiocarcinoma (n = 1), Wilms tumor (n = 1), and acute myeloid leukemia (n = 1). Nonneoplastic lymphoproliferation mimicking lymphoma was observed in five patients. The total overall survival (OS) was 62.5% +/- 12.1%. The OS for lymphoma was 62.2% +/- 17.1% and found to be inferior to non-PID patients with lymphoma (P = 0.001). Conclusion In patients with PIDs, malignancy may occur and negatively affect the OS. The diagnosis can be challenging in the presence of nonneoplastic lymphoproliferative disease or bone marrow abnormalities. Awareness of susceptibility to malignant transformation and early diagnosis with multidisciplinary approach can save the patients' lives.
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    Malignite şüphesi ile başvuran lenfadenopatili olguların değerlendirilmesi: tek merkez deneyimi
    (2022-10-01) EKER, NURŞAH; TOKUÇ, AYŞE GÜLNUR; Eker N., Keskin K. O., Tokuç A. G.
    Amaç: Çocukluk çağının en sık başvuru nedenini oluşturan lenfadenopatilere (LAP), genellikle öykü ve fizik muayene ile tanı konulabilir ve ek tetkik gerekmezken malign hastalık korkusu nedeni ile pek çok tetkik istenmekte ve hastalar uzun süre takipte tutulmaktadır. Bu çalışmada 2012-2021 yılları arasında LAP nedeni ile, merkezimiz Çocuk Onkoloji polikliniğine malignite şüphesi ile yönlendirilmiş olguların, dosya verileri taranarak geriye dönük olarak değerlendirilmesi amaçlanmıştır.Yöntem: Hastaların demografik verileri, tetkikleri, poliklinik başvuru sayıları, izlem süreleri, ek tetkiklerin tanıya katkısı ve tanıları geriye dönük olarak, benign grupta olup, başvuru anında, fizik muayenede LAP boyutu <2cm olan olgular (grup A), benign grupta, başvuru anı LAP boyutu >2cm olan olgular (grup B) ve malign hastalık gurubu (grup C) olarak üç gruba ayrılarak değerlendirildi.Bulgular: Grup C’de, yaş ortancası istatistiksel anlamlı olarak diğer gruplara göre daha yüksekti (p<0,001). Ek bulgu, istatistiksel anlamlı olarak malign grupta daha fazla hastada saptandı (p=0,002). Malign grupta istatistiksel anlamlı olarak daha az başvuru sayısı olduğu görüldü (p=0,026).Sonuç: Çocukluk çağı LAP etyolojisinin en sık sebebi benign nedenler iken tanıda en önemli basamağı öykü ve fizik muayene oluşturmaktadır. Seçilmiş hastalar dışında ek tetkikler hem radyasyon maruziyeti hem de ailelerde oluşturacağı stres nedeni ile düşünülerek istenmeli, takip sürelerinin de olgu bazında değerlendirilerek çok uzun tutulmaması gerektiğini düşünmekteyiz.Anahtar Kelimeler: Lenfadenopati, çocuk, kanser