Person: SEVİK, MEHMET ORKUN
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SEVİK
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MEHMET ORKUN
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Publication Open Access Predictive factors of complications and visual outcomes after pediatric cataract surgery: A single referral center study from Türkiye(2023-10-01) DERİCİOĞLU, VOLKAN; SEVİK, MEHMET ORKUN; BAĞATUR VURGUN, ELİF; ÇERMAN, EREN; DERİCİOĞLU V., SEVİK M. O., BAĞATUR VURGUN E., ÇERMAN E.Objectives: To evaluate the predictive factors of complications and visual acuity outcomes in pediatric cataract patients. Materials and Methods: This retrospective, observational clinical study included 80 eyes of 50 patients treated for pediatric cataracts between 2010 and 2020. The eyes were divided into Group I (congenital cataracts, n=38) and Group II (developmental cataracts, n=42). Group II was also divided into Group IIA (aphakic, n=21) and Group IIB (pseudophakic, n=21). The effects of the age, laterality, cataract morphology, intraocular lens implantation, preoperative nystagmus/strabismus, and intraoperative anterior hyaloid rupture on complications and final best-corrected visual acuity (BCVA; logMAR) were evaluated. Results: The median (interquartile range) age and follow-up time were 28 (5-79) months and 60 (29-84) months, respectively. There was a significant difference in mean final BCVA between Group I (0.79±0.46) and Group II (0.57±0.51) (p=0.047); however, no difference was observed between Group IIA and Group IIB (p=0.541). Having congenital cataract (p=0.045), preoperative nystagmus/strabismus (p=0.042), total/ mature cataract (p<0.001), and postoperative complications (p=0.07) were significantly associated with final BCVA. However, in multivariate analysis, only total/mature cataract (β: 0.52, p<0.001) and having any complication (β: 0.24, p=0.018) were associated with final BCVA. Congenital cataract and intraoperative anterior hyaloid rupture were the only significant risk factors of postoperative complications on univariate (p=0.027 and p=0.003, respectively) and binary logistic regression analysis (odds ratio [OR]: 2.95 [95% confidence interval: 1.07-8.15], p=0.036 and OR: 4.28 [95% confidence interval: 1.55-11.77], p=0.005, respectively). Conclusion: Total/mature cataract and the presence of any postoperative complication adversely affected the final BCVA. Having a congenital cataract and intraoperative anterior hyaloid membrane rupture increased the risk of complications.Publication Open Access Juvenile Xanthogranuloma Presented with Buphthalmos and Corneal Clouding in Neonatal Period: A Case Report(2022-05-01) DERİCİOĞLU, VOLKAN; SEVİK, MEHMET ORKUN; ERASLAN, MUHSİN; DERİCİOĞLU V., SEVİK M. O. , ERASLAN M., Dirican B., Yücelten D., Cinel L.Aim: To report an ocular juvenile xanthogranuloma (JXG) case presented with buphthalmos, corneal cloudiness, and normal intraocular pressure (IOP) in the neonatal period and treated with Ahmed glaucoma valve (AGV) implantation. Background: JXG is a rare disorder predominantly seen in infants, but the neonatal presentation is extraordinary. Although spontaneous hyphema is a common presenting sign in JXG, buphthalmos and corneal opacity in the neonatal period were reported only in one case, which had high IOP values at presentation. Case presentation: Sixteen-day-old male patient presented with buphthalmos, diffuse corneal clouding, and 11 mm Hg of IOP value in the right eye. IOP increased to 28 mm Hg three weeks later, and spontaneous hyphema developed, which did not respond to antiglaucomatous medications and topical corticosteroids. AGV was implanted, and the IOP decreased to 13 mm Hg postoperatively. In the follow-ups, numerous firm yellowish nodules were noticed on the patient’s skin during the examination under general anesthesia. Histopathological examination of the skin nodules was compatible with the diagnosis of JXG. Lens subluxation and phacodonesis were developed during the follow-up and were managed with pars plana lensectomy. After a silent period of 3 months, epithelial ingrowth was determined around the side port entrance. Unfortunately, the ingrowth did not respond to cryotherapy and resulted in phthisis bulbi. Pathological evaluation of the enucleated phthisic eye revealed posterior segment involvement. Conclusion: Ocular JXG can be present with buphthalmos, corneal opacity, and normal IOP values without any skin lesions in the neonatal period. Neonatal presentation of JXG may be associated with limited medical therapy response and aggressive disease course. Clinical significance: This case report introduces the second ocular JXG case, which presented with buphthalmos and corneal cloudiness, and the third pathologically proven posterior segment involvement of JXG in the literature.Publication Open Access A useful method for the practice of pneumatic retinopexy: Slit-lamp laser photocoagulation through the gas bubble(2023-05-01) SEVİK, MEHMET ORKUN; KUBAT, BETÜL; DERİCİOĞLU, VOLKAN; ŞAHİN, ÖZLEM; Aykut A., SEVİK M. O., KUBAT B., DERİCİOĞLU V., ŞAHİN Ö.This study aimed to demonstrate the laser retinopexy method through the gas bubble under a slit-lamp biomicroscope using a wide-field contact lens to treat rhegmatogenous retinal detachment (RRD) with pneumatic retinopexy (PR) and report its anatomical and functional results. This single-center, retrospective case series included RRD patients treated with PR using sulfur hexafluoride (SF6). The demographics, preoperative factors, and anatomical and functional outcomes were collected from the patient files. The single-procedure success rate of PR at postoperative 6th months was 70.8% (17/24 eyes), and the final success rate after secondary surgeries was 100%. The BCVA was better in the successful PR eyes at postoperative 3rd (p = 0.011) and 6th month (p = 0.016) than in failed eyes. No single preoperative factor was associated with PR success. The single-procedure success rate of PR using the laser retinopexy method through the gas bubble with a wide-field contact lens system seems comparable to the PR literature.Publication Open Access Choroidal vascularity index as an activity criterion and a treatment response measure in chronic central serous chorioretinopathy(2023-01-01) ŞAHİN, ÖZLEM; SEVİK, MEHMET ORKUN; ÇAM, FURKAN; DERİCİOĞLU, VOLKAN; SEVİK M. O., Aykut A., ÇAM F., DERİCİOĞLU V., ŞAHİN Ö.Purpose: This study aimed to evaluate the choroidal vascularity index (CVI) as an activity criterion in chronic central serous chorioretinopathy (CSC) and as a measure of treatment response after full-dose-full-fluence photodynamic therapy (fd-ff-PDT). Methods: This fellow-eye-controlled, retrospective cohort study included 23 patients with unilateral chronic CSC treated with fd-ff-PDT (6 mg/m2; 50 μcm2; 83 s). Subfoveal choroidal thickness (SFCT, μm) and CVI (%) of the affected and fellow eyes at baseline as well as at 1, 3 and 6 months after fd-ff-PDT were compared. Results: The patients\" mean age was 43.4 ± 7.3 years, and 18 (78.3%) were male. CVI was comparable between the affected and fellow eyes at baseline (66.09 ± 1.56 vs. 65.84 ± 1.57, p = 0.59). However, it became significantly lower in the affected eyes 1 (64.45 ± 1.68 vs. 65.87 ± 1.19, p = 0.002), 3 (64.21 ± 2.08 vs. 65.71 ± 1.59, p = 0.009) and 6 (64.47 ± 2.19 vs. 65.62 ± 1.52, p = 0.045) months after fd-ff-PDT. The mean SFCT and the mean CVI were significantly decreased in the affected eyes at all follow-up visits compared with baseline after fd-ff-PDT (p < 0.001). Conclusion: At baseline, CVI was comparable between affected and fellow eyes. Therefore, its use as an activity criterion in chronic CSC patients is questionable. However, it was significantly decreased in fd-ff-PDT-treated eyes, supporting its role as a measure of treatment response in chronic CSC.Publication Open Access Effect of age on primary balloon dacryocystoplasty and probing success in congenital nasolacrimal duct obstruction(2022-11-01) ÇERMAN, EREN; SEVİK, MEHMET ORKUN; ERASLAN, MUHSİN; DERİCİOĞLU, VOLKAN; DERİCİOĞLU V., Sevik M. O., Sacu S. S., ERASLAN M., ÇERMAN E.Purpose To compare the success rates of balloon dacryocystoplasty (BDP) and probing as a primary procedure in congenital nasolacrimal duct obstruction (CNLDO) and investigate the effect of age on both procedures. Methods A total of 135 patients (171 eyes) with simple and incomplete complex CNLDO were included in this retrospective study; complete complex CNLDO cases were excluded. The success rates for primary BDP (118 eyes) and for probing (53 eyes) were compared overall and among the age groups; Group 1 (12-24 months old), Group 2 (25-36 months old), and Group 3 (> 36 months old). Results Mean age of the patients was 41.5 +/- 27.2 months for primary BDP, and 21.8 +/- 10.8 months for probing (p < 0.001). Overall success rates for primary BDP and probing were 81.1% (43/53) and 76.3% (90/118), respectively (p = 0.481). Success rates for BDP and probing among age groups were 93.8% and 85.3% in Group 1 (p = 0.360), 93.3% and 50.0% in Group 2 (p = 0.012), and 63.6% and 27.3% in Group 3 (p = 0.052), respectively. Cox regression analysis showed that the median ages were 18 months for probing and 36 months for primary BDP. The Poisson regression model showed that for every 1-month increase in patients\" age, the success rate of probing decreased by 9.7%. Conclusion Probing success decreased to a point where different treatment options such as primary BDP can be discussed with the patients\" parents after 18 months of age. The success of BDP decreased after 36 months, while it maintained a high success rate between 24 and 36 months as primary treatment.Publication Open Access Leber konjenital amorozisi(2021-04-01) SEVİK, MEHMET ORKUN; ŞAHİN, ÖZLEM; Sevik M. O., Şahin Ö.Leber Konjenital Amorozisi (LKA), yaklaşık 150 yıl önce tanımlanan ve erken çocuklukta görme kaybıyla sonuçlanan, kalıtsal retina distrofilerinin en şiddetli olanlarından biridir. Doğumdan beri olan ya da bebeklik çağında başlayan görme kaybı, arayıcı nistagmus, zayıf ışık refleksi (amorotik pupil) ve tespit edilemez ya da ciddi azalmış tam-alan (full-field) ERG yanıtlarıyla karakterize olan hastalığın daha geç yaşlarda (genellikle 5 yaşından önce) başlayan \"Ciddi Erken Çocukluk Çağı Başlangıçlı Retinal Distrofi\" (CEBARD) olarak isimlendirilen daha hafif formlarının olduğu da bilinmektedir. LKA ve CEBARD klinik ve genetik olarak geniş çeşitlilik gösteren bir hastalık grubunu tanımlamaktadır. Günümüzde LKA/CEBARD’a sebep olduğu belirlenen 30 farklı gen mevcuttur ve tespit edilen bu genlerin hastalık spektrumunun yaklaşık %70-80’ini kapsadığı düşünülmektedir. Son yıllarda gen terapisi ile LKA/CEBARD tedavisinde ilk başarılı sonuçların bildirilmeye başlanması, hastalık grubunu araştırmaların ilgi odağı haline getirmiştir. Bu derlemede, LKA/CEBARD hastalığının genetik ve patofizyolojik temelleri, farklı genetik tiplerinin klinik özellikleri, tanısı, ayırıcı tanısı ve tedavisindeki güncel gelişmeler özetlenmektedir.Publication Open Access Untitled reply(2022-07-01) SEVİK, MEHMET ORKUN; ÇAM, FURKAN; ŞAHİN, ÖZLEM; DERİCİOĞLU, VOLKAN; SEVİK M. O., ÇAM F., Aykut A., DERİCİOĞLU V., ŞAHİN Ö.Publication Open Access Skin-only versus skin-plus-orbicularis resection blepharoplasty: an elaborated analysis of early- and long-term effects on corneal nerves, meibomian glands, dry eye parameters, and eyebrow position(2023-09-01) DERİCİOĞLU, VOLKAN; ŞAN, BURÇİN; SEVİK, MEHMET ORKUN; AKKAYA TURHAN, SEMRA; DERİCİOĞLU V., ŞAN B., SEVİK M. O., AKKAYA TURHAN S.Purpose: To evaluate the early- and long-term effects of 2 different blepharoplasty techniques on corneal nerves, meibomian gland morphology, clinical parameters of dry eye disease (DED), and eyebrow position. Methods: This prospective, interventional study included age-sex-matched blepharoplasty patients who had a skin-only resection (24 eyes of 12 patients; Group-S) or a skin-plus-orbicularis muscle resection (24 eyes of 12 patients; Group-M) procedure. Preoperative and postoperative parameters of in vivo corneal confocal microscopy (IVCCM; corneal nerve fiber density [CNFD], nerve branch density [CNBD], and nerve fiber length), meibomian gland area loss (MGAL), DED (Schirmer I test and noninvasive tear breakup time), and eyebrow heights (lateral [LBH] and central [CBH]) were evaluated and compared between the intervention groups (ClinicalTrials.gov, NCT05528016). Results: Compared with baseline, the CNBD of Group-S (19.91 ± 7.66 vs. 16.05 ± 7.28 branches/mm2, p = 0.049) and CNFD of Group-M (19.52 ± 7.45 vs. 16.80 ± 6.95 fibers/mm2, p = 0.028) was significantly decreased at postoperative first week. However, in both groups, IVCCM parameters returned to baseline values at postoperative first month and first year (p > 0.05). A significant MGAL increase was observed in Group-S (18.47 ± 5.43 vs. 19.94 ± 5.31, p = 0.030) and Group-M (18.86 ± 7.06 vs. 20.12 ± 7.01, p = 0.023) at the postoperative first year, demonstrating meibomian gland atrophy. Only significant changes were observed in Group-M in LBH (16.17 ± 2.45 vs. 16.67 ± 2.28 mm, p = 0.044) and CBH (17.33 ± 2.35 vs. 17.96 ± 2.31 mm, p = 0.004) at postoperative first year. Conclusions: Blepharoplasty with or without orbicularis resection seems to have similar effects on IVCCM, DED, and MGAL parameters. However, incorporating an orbicularis muscle resection in a blepharoplasty operation could slightly elevate the eyebrow position.Publication Open Access In vivo corneal confocal microscopy in multiple sclerosis: can it differentiate disease relapse in multiple sclerosis(2023-06-01) DERİCİOĞLU, VOLKAN; AKKAYA TURHAN, SEMRA; SEVİK, MEHMET ORKUN; ERDİL, ESRA; SÜNTER, GÜLİN; AĞAN YILDIRIM, KADRİYE; TOKER, AYŞE EBRU; DERİCİOĞLU V., AKKAYA TURHAN S., Erdem H. E., SEVİK M. O., ERDİL E., SÜNTER G., AĞAN YILDIRIM K., Toker E.PURPOSE: This study aims to investigate the role of in vivo corneal confocal microscopy (IVCCM) in the detection of corneal inflammatory activity and subbasal nerve alterations in patients with multiple sclerosis (MS) and to further determine whether IVCCM can be used to detect (acute) disease relapse.Publication Open Access Straatsma Syndrome: Should Visual Prognostic Factors Be Taken into Account? A Case Report(2021-12-01) SEVİK, MEHMET ORKUN; KARAMAN, NİYAZİ FATİH; ŞAHİN, ÖZLEM; Sevik M. O., Aykut A., Karaman N. F., ŞAHİN Ö.Straatsma syndrome is the triad of myelinated retinal nerve fibers, myopia, and amblyopia and may be associated with strabismus, nystagmus, hypoplastic optic nerve, and heterochromia iridum. The degree of anisometropia, presence of strabismus, extent of myelination, and macular involvement have been reported to be associated with poor visual acuity after occlusion therapy for amblyopia in this syndrome. Here we present two cases of Straatsma syndrome with different responses to occlusion therapy and discuss their treatment responses according to prognostic factors for post-occlusion visual acuity. Keywords: Amblyopia, myelinated retinal nerve fibers, straatsma syndrome, prognostic factors