Person: TUTAR, ENGİN
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TUTAR
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ENGİN
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Publication Open Access Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?(W J G PRESS, 2008) ÇELİKEL, ÇİĞDEM; Tutar, Engin; Ertem, Deniz; Unluguzel, Goksenin; Tanrikulu, Sevda; Haklar, Goncagul; Celikel, Cigdem; Ademoglu, Evin; Pehlivanoglu, EnderAIM: To determine the role of inflammatory cytokines and reactive oxygen species (ROS) in childhood reflux esophagitis. METHODS: A total of 59 subjects who had complaints suggesting GERD underwent esophagogastroduoden oscopy. Endoscopic and histopathologic diagnosis of reflux esophagitis was established by Savary-Miller and Vandenplas grading systems, respectively. Esophageal biopsy specimens were taken from the esophagus 20% proximal above the esophagogastric junction for conventional histopathological examination and the measurements of ROS and cytokine levels. ROS were measured by chemiluminescence, whereas IL-8 and MCP-1 levels were determined with quantitative immunometric ELISA on esophageal tissue. Esophageal tissue ROS, IL-8 and MCP-1 levels were compared among groups with and without endoscopic/histopathologic esophagitis. RESULTS: Of 59 patients 28 (47.5%) had normal esophagus whereas 31 (52.5%) had endoscopic esophagitis. In histopathological evaluation, almost 73% of the cases had mild and 6.8% had moderate degree of esophagitis. When ROS and chemokine levels were compared among groups with and without endoscopic esophagitis, statistical difference could not be found between patients with and without esophagitis. Although the levels of ROS, IL-8 and MCP-1 were found to be higher in the group with histopathological reflux esophagitis, this difference was not statistically significant. CONCLUSION: These results suggest that the grade of esophagitis is usually mild or moderate during childhood and factors apart from ROS, IL-8 and MCP-1 may be involved in the pathogenesis of reflux esophagitis in children. (C) 2008 The WJG Press. All rights reserved.Publication Open Access Can gastro-oesophageal reflux be predicted while advancing the endoscope through the laryngeal area? [7](2005-06-01) ERTEM ŞAHİNOĞLU, DENİZ; Ugras M., Ertem D., Cam S., Tutar E., Pehlivanoglu E.[No abstract available]Publication Metadata only Severe gastric outlet obstruction in a child with ectopic pancreas: Is there a role for Helicobacter pylori?(2006) ERTEM ŞAHİNOĞLU, DENİZ; Ertem D., Tutar E., Cam S., Ugras M., Pehlivanoglu E.[No abstract available]Publication Metadata only Endoscopic and Histopathologic Findings Associated with H-pylori Infection in Very Young Children(SPRINGER, 2009) ERTEM ŞAHİNOĞLU, DENİZ; Tutar, Engin; Ertem, Deniz; Karaa, Esin Kotiloglu; Pehlivanoglu, EnderMost of the individuals infected with H. pylori acquire the infection early in life. However, there is limited data regarding endoscopic and histopathologic findings of H. pylori infection when it is acquired during infancy. The aim of this study was to investigate the H. pylori-related endoscopic and histopathological findings in children younger than 2 years of age. One hundred and fifty-two infants who underwent upper gastrointestinal endoscopy were included in the study. The diagnosis of H. pylori infection was based on histopathology and a positive rapid urease test. Forty of 152 (26.3%) infants were infected with H. pylori, and 65% of the infected infants had histopathologic gastritis. There were no clinical or endoscopic findings suggestive of H. pylori infection. No correlation could be found between the density of H. pylori and the severity of gastritis. H. pylori infection is associated with various degrees of gastritis in more than half of the infected infants. Since the likelihood of normal histopathology is rare in H. pylori-infected infants, its long-term complications should be cautiously followed up in endemic areas.Publication Metadata only Gastric outlet obstruction: The role of H. pylori infection concomitant with ectopic pancreatic tissue(GEORG THIEME VERLAG KG, 2005) ERTEM ŞAHİNOĞLU, DENİZ; Ertem, D; Tutar, E; Cam, S; Pehlivanoglu, E