Person: OKTAY, NİHAL ŞEHKAR
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OKTAY
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NİHAL ŞEHKAR
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Publication Metadata only The effect of a single application of different fluoride varnishes on enamel subsurface lesions in vitro(2022-04-01) ŞEN YAVUZ, BETÜL; YILMAZ, MÜESSER AHU; OKTAY, NİHAL ŞEHKAR; KARGÜL, BETÜL; Yildiz P. K., ŞEN YAVUZ B., YILMAZ M. A., OKTAY N. Ş., KARGÜL B.This in vitro study aimed to evaluate the therapeutic effect of different fluoride ion (F) varnish formulations for controlling the carious development of enamel subsurface lesions and the F release into artificial saliva for 2 hr, 24 hr, 48 hr, and 7 days. Artificial enamel carious lesions were created and divided into 6 groups (5 varnish groups and a control group). Varnishes were applied to enamel specimens and then the specimens were incubated in artificial saliva, with the artificial saliva replenished daily. Varnish was removed and lesions were remineralized in artificial saliva for 24 hr. Surface microhardness was measured three times: (i) initially, (ii) after creating the artificial enamel lesions, and (iii) after applying the varnishes. The F release was analyzed after 2 hr, 24 hr, 48 hr, and 7 days of exposure using an ion-selective electrode. Data were analyzed using a One-way Analysis of Variance with the Tukey-Kramer Multiple Comparisons test and the Kruskal-Wallis test with the Dunns Multiple Comparisons test. The highest percentage surface microhardness recovery was found for the treatment with the MI Varnish. According to the percentage surface microhardness recovery results, a statistically significant difference was found between the varnishes and the control group (p < 0.05 and < 0.001). All varnishes released measurable levels of fluoride ions. However, the release of F was the highest in the MI Varnish group (p < 0.01). Duraphat, Enamel Pro Varnish, and MI Varnish released the most F into artificial saliva. Calcium phosphate-based F varnishes improve the capacity of the enamel surface re -hardening. CPP containing F varnish had the highest release of F as compared to the other F releasing varnishes. Further in vivo investigations are also required to prove the clinical applications of the different ingredients containing varnishes.Publication Metadata only A guide to vitamins and their effects on diseases(Cambridge University Press, Cambridge (MA), USA , 2023-01-01) OKTAY, NİHAL ŞEHKAR; Oktay N. Ş.This book provides a contemporary, comprehensive and general review of vitamins and the role of vitamins in diseases. In the first part of the book, readers will be informed about fat-soluble and water-soluble vitamins, vitamin-like substances, how they work in the body, their absorption, storage, transport, their recommended daily allowances, deficiencies and toxicity. In the second part, readers will discover how vitamins affect several diseases, and learn about their mechanism of action in diseases. The second part will also explore vitamin related minerals such as calcium, phosphorus, magnesium, potassium, copper and zinc. The book is unique in that it reveals the mechanism of action of each vitamin in relation to conditions such as the metabolism, autoimmune diseases, degenerative systems, infectious diseases, and aging. This book serves as a brief but beneficial guide for academic institutions, health professionals, practitioners, medical and dentistry students, nutritionists and pharmacists.Publication Metadata only Biochemical investigation of methotreaxate-induced oxidative stress on liver tissue(2023-11-23) OKTAY, NİHAL ŞEHKAR; Savaş Ş., Oktay N. Ş.