Person: SAK, MEHTAP
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SAK
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MEHTAP
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Publication Open Access Is renal abscess still a problem?(MARMARA UNIV, FAC MEDICINE, 2021-01-26) ALPAY, HARİKA; Sak, Mehtap; Gokce, Ibrahim; Cicek, Neslihan; Guven, Sercin; Ergelen, Rabia; Yildiz, Nurdan; Alpay, HarikaRenal abscess, the accumulation of infected fluid in the kidney, is a rare condition seen in children as well as adults. It leads to long term hospital admission and antibiotic use. Early diagnosis is an important factor in the outcome of renal abscess because the management may differ. Urinalysis test results and radiologic imaging findings of the patients who are admitted to hospital with complaints of fever, vomiting, abdominal pain or flank pain are important for the early diagnosis. Undertreated cases have high risk for renal scar formation. In this paper, we aim to present three pediatric patients, who showed the complication of renal abscess and were treated with long term antibiotic use without a need for surgical drainage.Publication Open Access Differential diagnosis of classical Bartter syndrome and Gitelman syndrome: Do we need genetic analysis?(MARMARA UNIV, FAC MEDICINE, 2021-10-31) ALAVANDA, CEREN; Guven, Sercin; Gokce, Ibrahim; Alavanda, Ceren; Cicek, Neslihan; Demirci, Ece Bodur; Sak, Mehtap; Pul, Serim; Turkkan, Ozde Nisa; Yildiz, Nurdan; Ata, Pinar; Alpay, HarikaObjective: Classical Bartter syndrome (cBS) and Gitelman syndrome (GS) are genotypically distinct, but there is a phenotypic overlap among these two diseases, which can complicate the accurate diagnosis without genetic analysis. This study aimed to evaluate the correlation between clinical and genetic diagnoses among patients who have genetically defined cBS and GS. Patients and Methods: The study included 18 patients with homozygous/compound heterozygous CLCNKB (NM_000085) (n:10/18) and SLC12A3 (NM_000339) (n:8/18) mutations. Biochemical, clinical and radiological data were collected at presentation and at the last visit. Results: In cBS group age at diagnosis, median plasma potassium and chloride concentrations were significantly lower and median plasma HCO3 and blood pH values were significantly higher. Patients with GS had significantly lower median plasma magnesium concentrations and urinary calcium/creatinine ratio. One child with GS had normocalciuria, two children with cBS had hypocalciuria and hypomagnesemia. Low estimated glomerular filtration rate (eGFR) (ml/dk/1.73m2) and growth failure were more evident in cBS group. In patients with cBS, nine different CLCNKB gene mutations were detected, five of them were novel. Novel mutations were: one nonsense (c.66G>A, p.Trp22*), one missense (c.499G>A, p.Gly167Ser) and three splice-site (c.867-2delA; c.499-2insG; c.19302A>C) mutations. In patients with GS, six different SLC12A3 gene mutations were found. Conclusions: It may not always be possible to clinically distinguish cBS from GS. We suggest to perform a genotypic classification if genetic analysis is possible.Publication Open Access Renal Artery Stenosis Presenting with Resistant Hypertension in Children and Adolescents: A Report of Five Cases(AVES, 2020-06-24) BALTACIOĞLU, FEYYAZ; Sak, Mehtap; Gokce, Ibrahim; Cicek, Neslihan; Yildiz, Nurdan; Baltacioglu, Feyyaz; Alpay, HarikaWe aimed to present five patients presenting with hypertension and diagnosed as renal artery stenosis. Five patients with renal artery stenosis were studied retrospectively. Two of our cases were diagnosed as fibromuscular dysplasia, other cases were diagnosed as Takayasu arteritis and Moyamoya disease, and one of them had congenital vascular abnormality. Renovascular hypertension is one of the most important causes of secondary hypertension in children, and renal artery stenosis constitutes a significant proportion of renovascular disease. We must consider renal artery stenosis in children presenting with resistant hypertension.