Plasma homocysteine concentration in patients with poor or good coronary collaterals

Abstract

Background Elevated plasma homocysteine (Hcy) concentrations are associated with an increased risk of vascular disease. Hcy is known to inhibit endothelial cell proliferation in vitro. The purpose of the present study was to investigate the role of plasma Hcy concentrations on development of collateral circulation in single-vessel chronic total occlusion. Methods and Results Collateral status was determined by Rentrop's classification. Of 817 patients, 56 cases of pure single-vessel chronic total occlusion were studied. Plasma Hcy concentrations in patients with single-vessel total coronary occlusion were higher compared with controls (17.3 +/- 12.6 mu mol/L vs 10.9 +/- 4.9 mu mol/L, p = 0.015). There was no significant difference in plasma Hey concentrations of the good and poor collateral groups (17.2 +/- 13.7 mu mol/L vs 15.3 +/- 9.3 mu mol/L, p = 0.834). Plasma Hcy concentrations in individual Rentrop subclasses 0, 1, 2 and 3 were as follows: 15.9 +/- 9.1, 16.3 +/- 12.4, 17.1 +/- 14.1 and 20.1 +/- 13.5 mu mol/L (p = 0.893). There was a positive linear correlation between Rentrop subclass and angina pectoris duration (r = 0.41, p = 0.003). Angina pectoris duration was the only independent variable affecting the development of coronary collaterals in the present study (odds ratio [confidence interval]: 1.85 [1.12-2.91], p = 0.014). Conclusion Patients with single-vessel chronic total occlusion had higher plasma Hcy concentrations than controls, but similar Hey concentrations when compared according to the presence of poor or good coronary collaterals. There is a lack of association between plasma Hcy concentration and coronary collateral status in the current study.